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View Structure Prediction Details

Protein: FOL2
Organism: Saccharomyces cerevisiae
Length: 243 amino acids
Reference: Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076



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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for FOL2.

Description E-value Query
Range		 Subject
Range
GCH1_YEAST - GTP cyclohydrolase 1 OS=Saccharomyces cerevisiae (strain ATCC 204508 / S288c) GN=FOL2 PE=1 SV=1
gi|151943540 - gi|151943540|gb|EDN61851.1| GTP-cyclohydrolase I [Saccharomyces cerevisiae YJM789]
FOL2 - GTP-cyclohydrolase I, catalyzes the first step in the folic acid biosynthetic pathway
gi|207344895 - gi|207344895|gb|EDZ71884.1| YGR267Cp-like protein [Saccharomyces cerevisiae AWRI1631]
gi|190406730 - gi|190406730|gb|EDV09997.1| GTP-cyclohydrolase I [Saccharomyces cerevisiae RM11-1a]
 0.0 [1..243] [1..243]
gi|255061 - gi|255061|gb|AAB23164.1| GTP cyclohydrolase I [Homo sapiens]
 8.0E-98 [5..240] [8..241]
GCH1_RAT - GTP cyclohydrolase 1 OS=Rattus norvegicus GN=Gch1 PE=1 SV=1
 1.0E-96 [4..240] [7..241]
GCH1_MOUSE - GTP cyclohydrolase 1 OS=Mus musculus GN=Gch1 PE=1 SV=1
 6.0E-96 [4..240] [7..241]
gi|13272331 - gi|13272331|gb|AAK17098.1|AF288421_1 N-terminal truncated GTP cyclohydrolase I [synthetic construct]
 8.0E-90 [32..240] [2..210]
SPAC17A5.13 - GTP cyclohydrolase
GCH1_SCHPO - GTP cyclohydrolase 1 OS=Schizosaccharomyces pombe (strain 972 / ATCC 24843) GN=SPAC17A5.13 PE=1 SV=1
 1.0E-85 [14..240] [10..234]
GCH1_CHICK - GTP cyclohydrolase 1 OS=Gallus gallus GN=GCH1 PE=2 SV=1
 1.0E-85 [1..240] [1..236]

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Predicted Domain #1
Region A:
Residues: [1-243] 
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MHNIQLVQEI ERHETPLNIR PTSPYTLNPP VERDGFSWPS VGTRQRAEET EEEEKERIQR  60
   61 ISGAIKTILT ELGEDVNREG LLDTPQRYAK AMLYFTKGYQ TNIMDDVIKN AVFEEDHDEM 120
  121 VIVRDIEIYS LCEHHLVPFF GKVHIGYIPN KKVIGLSKLA RLAEMYARRL QVQERLTKQI 180
  181 AMALSDILKP LGVAVVMEAS HMCMVSRGIQ KTGSSTVTSC MLGGFRAHKT REEFLTLLGR 240
  241 RSI

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 735.522879
Match: 1is7A_
Description: GTP cyclohydrolase I
Matching Structure (courtesy of the PDB):

Predicted functions:

Term Confidence Notes
GTP cyclohydrolase I activity 5.27071565931386 bayes_pls_golite062009
cyclohydrolase activity 3.66553359909123 bayes_pls_golite062009
GTP cyclohydrolase activity 3.44912994722205 bayes_pls_golite062009
6-pyruvoyltetrahydropterin synthase activity 2.94513271787536 bayes_pls_golite062009
catalytic activity 2.20788162511962 bayes_pls_golite062009
hydrolase activity 1.99585429337181 bayes_pls_golite062009
dihydroneopterin aldolase activity 1.96466418682643 bayes_pls_golite062009
hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amidines 1.73101699306211 bayes_pls_golite062009
binding 1.62520629128577 bayes_pls_golite062009
protein binding 1.34873192832825 bayes_pls_golite062009
hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds 0.974891318710762 bayes_pls_golite062009
carbon-carbon lyase activity 0.25616855487144 bayes_pls_golite062009
urate oxidase activity 0.0294957696532921 bayes_pls_golite062009
YRC Informatics Platform - Version 3.0
Created and Maintained by: Michael Riffle