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Protein Overview: GCD11

General Information:
Name(s) found: GCD11 / YER025W [SGD]
Description(s) found:
Found 27 descriptions.
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  • Gamma subunit of the translation initiation factor eIF2, involved in the identification of the start codon; binds GTP when forming the ternary complex with GTP and tRNAi-Met [SGD]
    • Organism: Saccharomyces cerevisiae
    Length: 527 amino acids

    Gene Ontology:
    Cellular Component: multi-eIF complex [IDALink to PubMed article]
    ribosome [TASLink to PubMed article]
    eukaryotic translation initiation factor 2 complex [IMPLink to PubMed article][ISSLink to PubMed article]
    Biological Process: translational initiation [TASLink to PubMed article]
    Molecular Function: translation initiation factor activity [TASLink to PubMed article]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MSDLQDQEPS IIINGNLEPV GEPDIVEETE VVAQETQETQ DADKPKKKVA FTGLEEDGET  60
   61 EEEKRKREFE EGGGLPEQPL NPDFSKLNPL SAEIINRQAT INIGTIGHVA HGKSTVVRAI 120
  121 SGVQTVRFKD ELERNITIKL GYANAKIYKC QEPTCPEPDC YRSFKSDKEI SPKCQRPGCP 180
  181 GRYKLVRHVS FVDCPGHDIL MSTMLSGAAV MDAALLLIAG NESCPQPQTS EHLAAIEIMK 240
  241 LKHVIILQNK VDLMREESAL EHQKSILKFI RGTIADGAPI VPISAQLKYN IDAVNEFIVK 300
  301 TIPVPPRDFM ISPRLIVIRS FDVNKPGAEI EDLKGGVAGG SILNGVFKLG DEIEIRPGIV 360
  361 TKDDKGKIQC KPIFSNIVSL FAEQNDLKFA VPGGLIGVGT KVDPTLCRAD RLVGQVVGAK 420
  421 GHLPNIYTDI EINYFLLRRL LGVKTDGQKQ AKVRKLEPNE VLMVNIGSTA TGARVVAVKA 480
  481 DMARLQLTSP ACTEINEKIA LSRRIEKHWR LIGWATIKKG TTLEPIA

    Protein Complex Data

      PUBLICATION TOPOLOGY COCOMPLEXED PROTEINS
    View Details Riffle et al. (2010) (Unpublished Data) CDC123 GCD1 GCD11 GCD2 GCD6 GCD7 GCN3 HCR1 NIP1 PRT1 RPG1 SUI2 SUI3 TIF34 TIF35 TIF5
    View Details (MIPS) Mewes HW, et al. (2004) GCD11 SUI2 SUI3
    View Details Krogan NJ, et al. (2006) ADE1 GCD1 GCD11 GCD2 GCD6 GCD7 GCN3 MRF1 MRH4 SUI2
    View Details Gavin AC, et al. (2006) GCD1 GCD11 GCD2 GCD6 GCD7 GCN3
    View Details Gavin AC, et al. (2002) CCT4 CHC1 COG8 GCD1 GCD11 GCD2 GCD6 GCD7 GCN3 GUT1 IST1 PDC1 PRO1 RRP40 RRP46 SUI2 SUI3 XKS1
    View Details Ho Y, et al. (2002) AAC1 AAC3 ACC1 ACH1 ADE5,7 ADH2 ADR1 AHA1 AHP1 ARC1 ARO1 ARP2 ATG11 ATG12 ATG17 ATP3 BEM2 BGL2 CAR2 CBP6 CCT2 CCT3 CCT5 CCT6 CDC123 CDC15 CDC33 COR1 CPA2 CPR6 DUG2 DUN1 ECM10 EGD1 FAA4 FAL1 FET3 FET4 FRS2 GCD1 GCD11 GCD2 GCD6 GCD7 GCN3 GFA1 GLT1 GND1 GPA1 GUS1 HOM3 HOR2 HTB1 HXT7 IDH2 ILV2 IPP1 ISA2 LOS1 MCX1 MDH1 MET18 NAP1 NDE1 NGL2 NMD3 NMD5 NPA3 OYE2 PET10 PET9 PIL1 PPX1 PRB1 PRO3 PRP19 PST2 PTC3 PTC7 PYC1 PYC2 QCR2 RAD52 RAD59 REP1 RET1 REX2 RFA2 RHR2 RNQ1 RPA135 RPA190 RPA49 RPB5 RPC19 RPC25 RPC34 RPC40 RPC82 RPN10 RPN11 RPN3 RPN5 RPN6 RPN7 RPO26 RPO31 RPT1 RPT3 RVS167 SAR1 SCW4 SEC18 SEC27 SEC53 SLC1 SOD1 SPC24 SPC25 STE4 SUI2 SUI3 TBS1 TCB1 TCP1 TEF4 TEM1 TFP1 TIF1, TIF2 TIF4631 TIF4632 TRP3 TRP5 TSA2 TYR1 UBA1 VAC8 VMA8 VPS8 YER138C YFL042C YHR020W YHR033W YHR112C YJU2 YNK1 YNL208W YPT31
    View Details Qiu et al. (2008) FUN12 GCD11 NIP1 PRT1 SUI1 SUI2 SUI3 TIF3 TIF34 TIF35 TIF5 YGR054W

    Mass Spectrometry Data

    The following runs contain data for this protein:

      BAIT COMMENTS PUBLICATION
    View Run CEP3 sample cbf3 from feb 2005 Sandall S, et all (2006)
    View Run BOI1 Sample bob1 (2nd set) from october 2005 McCusker D, et al (2007)
    View Run MLP2 #03 Alpha Factor Prep1-TiO2 Flowthrough Keck JM, et al. (2011)
    View Run MLP2 #12 Mitotic Prep1-TiO2 Flowthrough Keck JM, et al. (2011)

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    NOT SHOWING SINGLE HITS. [ Show Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

    No yeast two-hybrid interactions found for this protein.

    Microscopy / Localization Data

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      PROTEIN(S) PUBLICATION
    View Data GCD11 Huh WK, et al. (2003)

    Protein Structure Data


    [What does the above image mean?]
    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..79] deduced N/A No confident structure predictions are available.
    2 View Details [80..305] PSI-BLAST 1113.0 Initiation factor eIF2 gamma subunit, domain II; Initiation factor eIF2 gamma subunit; Initiation factor eIF2 gamma subunit, N-terminal (G) domain
    3 View Details [306..424] PSI-BLAST 1113.0 Initiation factor eIF2 gamma subunit, domain II; Initiation factor eIF2 gamma subunit; Initiation factor eIF2 gamma subunit, N-terminal (G) domain
    4 View Details [425..527] PSI-BLAST 1113.0 Initiation factor eIF2 gamma subunit, domain II; Initiation factor eIF2 gamma subunit; Initiation factor eIF2 gamma subunit, N-terminal (G) domain


    Reference: Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076


    Philius Transmembrane Prediction:

    Protein predicted to be: GLOBULAR (No transmembrane regions or signal peptide)
    Confidence of classification: 0.90

    Source: Reynolds et al. (2008)

    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle