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Protein Overview: LHP1

General Information:
Name(s) found: LHP1 / YDL051W [SGD]
Description(s) found:
Found 34 descriptions.
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  • RNA binding protein required for maturation of tRNA and U6 snRNA precursors; acts as a molecular chaperone for RNAs transcribed by polymerase III; homologous to human La (SS-B) autoantigen [SGD]
    • Organism: Saccharomyces cerevisiae
    Length: 275 amino acids

    Gene Ontology:
    Cellular Component: nucleus [IDALink to PubMed article]
    nucleolus [IDALink to PubMed article]
    nucleoplasm [IDALink to PubMed article]
    Biological Process: tRNA processing [IMPLink to PubMed article]
    Molecular Function: RNA binding [IDALink to PubMed article]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MSEKPQQEEQ EKPQSRRNSF AVIEFTPEVL DRCLKQVEFY FSEFNFPYDR FLRTTAEKND  60
   61 GWVPISTIAT FNRMKKYRPV DKVIEALRSS EILEVSADGE NVKRRVPLDL TAARNARIEQ 120
  121 NQRTLAVMNF PHEDVEASQI PELQENLEAF FKKLGEINQV RLRRDHRNKK FNGTVLVEFK 180
  181 TIPECEAFLK SYSNDDESNE ILSYEGKKLS VLTKKQFDLQ REASKSKNFS GRSRSFNGHK 240
  241 KKNLPKFPKN KKKNGKEESK EDSSAIADDD EEHKE

    Protein Complex Data

      PUBLICATION TOPOLOGY COCOMPLEXED PROTEINS
    View Details Riffle et al. (2010) (Unpublished Data) LHP1 NSA2 POL2 SEC65 SRP14 SRP21 SRP54 SRP68 SRP72 TIF4631 TIF4632
    View Details Krogan NJ, et al. (2006) LHP1 SEC65 SRP14 SRP21 SRP54 SRP68 SRP72 YCR090C
    View Details Gavin AC, et al. (2006) LHP1 SXM1 UTP30
    View Details Gavin AC, et al. (2002) AAR2 ARX1 ASC1 BEM2 BMS1 BRX1 BUD20 CBF5 CDC33 CIC1 CLU1 CYR1 CYS4 DBP10 DBP2 DBP9 DCP2 DRS1 EBP2 ERB1 FPR4 FUN12 GAR1 GCN1 HAS1 HCA4 HDA1 HEK2 HER1 HHF1, HHF2 HIS3 IML1 INP2 IPI1 IPI3 KRE33 KRR1 LHP1 LOC1 LSG1 MAK21 MAK5 MDN1 MIS1 MRP7 MRT4 NAB3 NAB6 NAM7 NAP1 NHP2 NIP1 NIP7 NMD3 NOC2 NOC3 NOG1 NOG2 NOP1 NOP12 NOP15 NOP16 NOP2 NOP4 NOP56 NOP6 NOP7 NPL3 NRD1 NRP1 NSA1 NSA2 NUG1 POL2 PRP4 PRT1 PUB1 PUF6 PUS7 RBG1 REI1 RIX1 RIX7 RLP24 RLP7 ROM2 RPA135 RPA190 RPF1 RPF2 RPG1 RPP2B RPT6 RRP1 RRP12 RSA3 RSA4 RTR1 SBP1 SDA1 SEC65 SEC7 SGN1 SKI2 SMB1 SMD3 SNF2 SNP1 SNU114 SNU13 SNU66 SPB1 SPB4 SRO9 SRP14 SRP21 SRP54 SRP68 SRP72 SSF1 STM1 STO1 SUI3 SWI1 TIF1, TIF2 TIF4631 TIF4632 TIF6 TUB3 URB1 UTP10 UTP20 UTP21 UTP22 YGL036W YMR310C YTM1
    View Details Ho Y, et al. (2002) AFG2 ALB1 ARX1 BUD20 CDC33 CKA1 CKA2 CKB1 ECM1 EHD3 ESF1 ESF2 FYV4 HHF1, HHF2 HTA1 HTB1 HTB2 IMD3 LAA1 LHP1 MAM33 MNP1 MRPS16 MSS116 NMD3 NOG1 NOP12 NOP13 NOP7 NSA2 NUG1 PMA1 PRP43 PUF6 PWP1 RIX1 RPF2 RSM24 RSM25 SXM1 YBL044W YCR087W YDR102C YRA1

    Mass Spectrometry Data

    The following runs contain data for this protein:

      BAIT COMMENTS PUBLICATION
    View Run RPA135 No Comments Schneider, DA, et al. (2006)

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    SHOWING SINGLE HITS. [ Hide Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

      BAIT PREY HITS PUBLICATION
    View Screen UBC7 LHP1 1 Unpublished Fields Lab Data

    Microscopy / Localization Data

    New Feature: Upload Your Own Microscopy Data

      PROTEIN(S) PUBLICATION
    View Data LHP1 Huh WK, et al. (2003)

    Protein Structure Data


    [What does the above image mean?]
    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..107] PSI-BLAST 27.522879 Poly(A)-binding protein
    2 View Details [108..275] PSI-BLAST 27.522879 Poly(A)-binding protein

    Functions predicted (by domain):

    # Gene Ontology predictions
    1
    Term Confidence Notes
  • RNA binding
    		•  4.46119712758726 bayes_pls_golite062009
  • nucleic acid binding
    		•  3.81920018903278 bayes_pls_golite062009
  • mRNA binding
    		•  3.05425904007847 bayes_pls_golite062009
  • binding
    		•  3.05116833253954 bayes_pls_golite062009
    		• 2.36751082234253 bayes_pls_golite062009
  • transcription regulator activity
    		•  1.07788694919471 bayes_pls_golite062009
  • DNA binding
    		•  0.978604858165557 bayes_pls_golite062009
  • single-stranded RNA binding
    		•  0.852368751354665 bayes_pls_golite062009
  • ligase activity
    		•  0.633198446266208 bayes_pls_golite062009
  • poly-pyrimidine tract binding
    		•  0.56829350502235 bayes_pls_golite062009
  • protein binding
    		•  0.42571879933058 bayes_pls_golite062009
  • transcription factor activity
    		•  0.234742017105535 bayes_pls_golite062009
  • snoRNA binding
    		•  0.13655584674226 bayes_pls_golite062009
  • structural molecule activity
    		•  0.0823205596024605 bayes_pls_golite062009
    2 No functions predicted.


    Reference: Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076


    Philius Transmembrane Prediction:

    Protein predicted to be: GLOBULAR (No transmembrane regions or signal peptide)
    Confidence of classification: 0.99

    Source: Reynolds et al. (2008)

    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle