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Protein Overview: ACC1

General Information:
Name(s) found: ACC1 / YNR016C [SGD]
Description(s) found:
Found 27 descriptions.
SHOW ALL
  • Acetyl-CoA carboxylase, biotin containing enzyme that catalyzes the carboxylation of acetyl-CoA to form malonyl-CoA; required for de novo biosynthesis of long-chain fatty acids [SGD]
    • Organism: Saccharomyces cerevisiae
    Length: 2233 amino acids

    Gene Ontology:
    Cellular Component: endoplasmic reticulum membrane [IDALink to PubMed article]
    mitochondrion [IDALink to PubMed articleLink to PubMed article]
    cytosol [TAS]
    Biological Process: nuclear envelope organization [TASLink to PubMed article]
    protein import into nucleus [IMPLink to PubMed article]
    fatty acid biosynthetic process [TAS]
    Molecular Function: acetyl-CoA carboxylase activity [IMPLink to PubMed article][ISSLink to PubMed article]
    biotin carboxylase activity [IMPLink to PubMed article][ISSLink to PubMed article]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MSEESLFESS PQKMEYEITN YSERHTELPG HFIGLNTVDK LEESPLRDFV KSHGGHTVIS  60
   61 KILIANNGIA AVKEIRSVRK WAYETFGDDR TVQFVAMATP EDLEANAEYI RMADQYIEVP 120
  121 GGTNNNNYAN VDLIVDIAER ADVDAVWAGW GHASENPLLP EKLSQSKRKV IFIGPPGNAM 180
  181 RSLGDKISST IVAQSAKVPC IPWSGTGVDT VHVDEKTGLV SVDDDIYQKG CCTSPEDGLQ 240
  241 KAKRIGFPVM IKASEGGGGK GIRQVEREED FIALYHQAAN EIPGSPIFIM KLAGRARHLE 300
  301 VQLLADQYGT NISLFGRDCS VQRRHQKIIE EAPVTIAKAE TFHEMEKAAV RLGKLVGYVS 360
  361 AGTVEYLYSH DDGKFYFLEL NPRLQVEHPT TEMVSGVNLP AAQLQIAMGI PMHRISDIRT 420
  421 LYGMNPHSAS EIDFEFKTQD ATKKQRRPIP KGHCTACRIT SEDPNDGFKP SGGTLHELNF 480
  481 RSSSNVWGYF SVGNNGNIHS FSDSQFGHIF AFGENRQASR KHMVVALKEL SIRGDFRTTV 540
  541 EYLIKLLETE DFEDNTITTG WLDDLITHKM TAEKPDPTLA VICGAATKAF LASEEARHKY 600
  601 IESLQKGQVL SKDLLQTMFP VDFIHEGKRY KFTVAKSGND RYTLFINGSK CDIILRQLSD 660
  661 GGLLIAIGGK SHTIYWKEEV AATRLSVDSM TTLLEVENDP TQLRTPSPGK LVKFLVENGE 720
  721 HIIKGQPYAE IEVMKMQMPL VSQENGIVQL LKQPGSTIVA GDIMAIMTLD DPSKVKHALP 780
  781 FEGMLPDFGS PVIEGTKPAY KFKSLVSTLE NILKGYDNQV IMNASLQQLI EVLRNPKLPY 840
  841 SEWKLHISAL HSRLPAKLDE QMEELVARSL RRGAVFPARQ LSKLIDMAVK NPEYNPDKLL 900
  901 GAVVEPLADI AHKYSNGLEA HEHSIFVHFL EEYYEVEKLF NGPNVREENI ILKLRDENPK 960
  961 DLDKVALTVL SHSKVSAKNN LILAILKHYQ PLCKLSSKVS AIFSTPLQHI VELESKATAK1020
 1021 VALQAREILI QGALPSVKER TEQIEHILKS SVVKVAYGSS NPKRSEPDLN ILKDLIDSNY1080
 1081 VVFDVLLQFL THQDPVVTAA AAQVYIRRAY RAYTIGDIRV HEGVTVPIVE WKFQLPSAAF1140
 1141 STFPTVKSKM GMNRAVSVSD LSYVANSQSS PLREGILMAV DHLDDVDEIL SQSLEVIPRH1200
 1201 QSSSNGPAPD RSGSSASLSN VANVCVASTE GFESEEEILV RLREILDLNK QELINASIRR1260
 1261 ITFMFGFKDG SYPKYYTFNG PNYNENETIR HIEPALAFQL ELGRLSNFNI KPIFTDNRNI1320
 1321 HVYEAVSKTS PLDKRFFTRG IIRTGHIRDD ISIQEYLTSE ANRLMSDILD NLEVTDTSNS1380
 1381 DLNHIFINFI AVFDISPEDV EAAFGGFLER FGKRLLRLRV SSAEIRIIIK DPQTGAPVPL1440
 1441 RALINNVSGY VIKTEMYTEV KNAKGEWVFK SLGKPGSMHL RPIATPYPVK EWLQPKRYKA1500
 1501 HLMGTTYVYD FPELFRQASS SQWKNFSADV KLTDDFFISN ELIEDENGEL TEVEREPGAN1560
 1561 AIGMVAFKIT VKTPEYPRGR QFVVVANDIT FKIGSFGPQE DEFFNKVTEY ARKRGIPRIY1620
 1621 LAANSGARIG MAEEIVPLFQ VAWNDAANPD KGFQYLYLTS EGMETLKKFD KENSVLTERT1680
 1681 VINGEERFVI KTIIGSEDGL GVECLRGSGL IAGATSRAYH DIFTITLVTC RSVGIGAYLV1740
 1741 RLGQRAIQVE GQPIILTGAP AINKMLGREV YTSNLQLGGT QIMYNNGVSH LTAVDDLAGV1800
 1801 EKIVEWMSYV PAKRNMPVPI LETKDTWDRP VDFTPTNDET YDVRWMIEGR ETESGFEYGL1860
 1861 FDKGSFFETL SGWAKGVVVG RARLGGIPLG VIGVETRTVE NLIPADPANP NSAETLIQEP1920
 1921 GQVWHPNSAF KTAQAINDFN NGEQLPMMIL ANWRGFSGGQ RDMFNEVLKY GSFIVDALVD1980
 1981 YKQPIIIYIP PTGELRGGSW VVVDPTINAD QMEMYADVNA RAGVLEPQGM VGIKFRREKL2040
 2041 LDTMNRLDDK YRELRSQLSN KSLAPEVHQQ ISKQLADRER ELLPIYGQIS LQFADLHDRS2100
 2101 SRMVAKGVIS KELEWTEARR FFFWRLRRRL NEEYLIKRLS HQVGEASRLE KIARIRSWYP2160
 2161 ASVDHEDDRQ VATWIEENYK TLDDKLKGLK LESFAQDLAK KIRSDHDNAI DGLSEVIKML2220
 2221 STDDKEKLLK TLK

    Protein Complex Data

      PUBLICATION TOPOLOGY COCOMPLEXED PROTEINS
    View Details Krogan NJ, et al. (2006) ACC1 HFA1
    View Details Gavin AC, et al. (2002) ACC1 AVT4 BEM2 CCT2 CCT5 CCT8 CDC25 CLU1 CPA2 FAB1 FDH1 GCN20 GFA1 GUS1 HRK1 ILV1 KAP123 LYS12 MDS3 MIA40 MRPL3 PSA1 RPA135 RPB2 RPN10 RPN11 RPN12 RPN8 RPT3 RPT5 RPT6 SAM1 SAP155 SAP185 SAP190 SEC27 SIT4 SMC3 SWT21 TCB1 TIF1, TIF2 TSA1 TUB3 URA7 VAC14 VAS1 YOL098C
    View Details Ho Y, et al. (2002) ACC1 ACH1 ADH2 ADR1 AHA1 ARC35 ARO4 ARP2 ATP3 BGL2 CCT3 CCT6 CDC60 COP1 CPA2 CPR6 DEF1 DMC1 DPM1 FAA1 FAA4 FOL2 GAL7 GCD11 GFA1 GLT1 GND1 GSF2 GUS1 IDH1 IDH2 ILS1 ISA2 KGD2 LIA1 LSC1 LST8 LYS12 MAE1 MDH1 MDJ1 MET18 NDE1 NGL2 NOP14 NPA3 OLA1 PHO86 POR1 PYC1 PYC2 RET1 RMT2 RNR2 RPA135 RPA190 RPA49 RPB5 RPC19 RPC25 RPC34 RPC40 RPC82 RPN12 RPN3 RPO26 RPO31 RPT4 RRP3 RVB2 RVS167 SAP155 SAP185 SAP190 SEC27 SEC53 SGD1 SHS1 SIP1 SIT4 SLC1 SMC4 STI1 TAP42 TBS1 TFP1 TRP3 TRP5 TSA2 URE2 UTP5 VMA4 YBT1 YER138C YFL042C YHR033W YHR112C YKU80 YML020W YMR196W

    Mass Spectrometry Data

    The following runs contain data for this protein:

      BAIT COMMENTS PUBLICATION
    View Run TIM50 No Comments Hazbun TR, et al. (2003)
    View Run NSL1 No Comments Hazbun TR, et al. (2003)
    View Run PAN1 No Comments Toshima J, et al (2006)
    View Run RPA135 his-HA tag on RPA135 Schneider, DA, et al. (2006)
    View Run RPA135 his-HA tag on RPA135 Schneider, DA, et al. (2006)
    View Run DAD1 Dam1-765 complex purified from yeast with Dad1-TAP Shimogawa MM, et al. (2006)
    View Run CEP3 sample cbf3 from feb 2005 Sandall S, et all (2006)
    View Run DAD1 Dam1-765 complex purified from yeast with Dad1-TAP Shimogawa MM, et al. (2006)
    View Run RPA135 No Comments Schneider, DA, et al. (2006)
    View Run RLF2 phosphorylation data - cascade search Green EM, et al (2005)
    View Run RLF2 identification data - first search in cascade Green EM, et al (2005)
    View Run ZDS1 Sample 2- cpn2 from june 2005 McCusker D, et al (2007)
    View Run ZDS1 Sample 3 - cpn + atp, from june 2005 McCusker D, et al (2007)
    View Run BOI1 Sample boi 1 with ha tag from october 2005 McCusker D, et al (2007)
    View Run BOI1 Sample boi1 with gst from october 2005 McCusker D, et al (2007)
    View Run BOI1 Sample bob1 (2nd set) from october 2005 McCusker D, et al (2007)
    View Run BOI2 Boi 2 gst control McCusker D, et al (2007)
    View Run MLP2 #19 Asynchronous Prep1-TiO2 Phosphopeptide enrichment Keck JM, et al. (2011)
    View Run MLP2 #25 Asynchronous Prep3-TiO2 Flowthrough Keck JM, et al. (2011)
    View Run MLP2 #24 Asynchronous Prep3-TiO2 Phosphopeptide enrichment Keck JM, et al. (2011)
    View Run MLP2 #32 Asynchronous Prep-No Phosphopeptide enrichment Keck JM, et al. (2011)
    View Run MLP2 #31 Asynchronous Prep (Protease cleavage) Keck JM, et al. (2011)
    View Run MLP2 #29 Asynchronous Prep5-TiO2 Flowthrough Keck JM, et al. (2011)
    View Run MLP2 #06 Alpha Factor Prep3-TiO2 Phosphopeptide enrichment Keck JM, et al. (2011)
    View Run MLP2 #19b Asynchronous Prep1-new search criteria Keck JM, et al. (2011)
    View Run MLP2 #19a Asynchronous Prep1-new search criteria Keck JM, et al. (2011)

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    SHOWING SINGLE HITS. [ Hide Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

      BAIT PREY HITS PUBLICATION
    View Screen SDP1 ACC1 1 Unpublished Fields Lab Data

    Microscopy / Localization Data

    New Feature: Upload Your Own Microscopy Data

      PROTEIN(S) PUBLICATION
    View Data ACC1 Huh WK, et al. (2003)

    Protein Structure Data


    [What does the above image mean?]
    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..174] PSI-BLAST 700.228787 Biotin carboxylase subunit of acetyl-CoA carboxylase (BC), C-domain; Biotin carboxylase subunit of acetyl-CoA carboxylase, (BC), N-domain; Biotin carboxylase subunit of acetyl-CoA carboxylase (BC), domain 2
    2 View Details [175..201]
    [293..318]
    [332..452]    		 PSI-BLAST 700.228787 Biotin carboxylase subunit of acetyl-CoA carboxylase (BC), C-domain; Biotin carboxylase subunit of acetyl-CoA carboxylase, (BC), N-domain; Biotin carboxylase subunit of acetyl-CoA carboxylase (BC), domain 2
    3 View Details [202..292]
    [319..331]
    [453..603]    		 PSI-BLAST 700.228787 Biotin carboxylase subunit of acetyl-CoA carboxylase (BC), C-domain; Biotin carboxylase subunit of acetyl-CoA carboxylase, (BC), N-domain; Biotin carboxylase subunit of acetyl-CoA carboxylase (BC), domain 2
    4 View Details [604..695] deduced N/A Confident ab initio structure predictions are available.
    5 View Details [696..781] PSI-BLAST 12.522879 Biotin carboxyl carrier domain of transcarboxylase (TC 1.3S)
    6 View Details [782..989] deduced N/A No confident structure predictions are available.
    7 View Details [990..1091] MSA 1.037977 View MSA. Confident ab initio structure predictions are available.
    8 View Details [1092..1154] deduced N/A No confident structure predictions are available.
    9 View Details [1155..1328] MSA 1.036981 View MSA. No confident structure predictions are available.
    10 View Details [1329..1527] MSA 1.04297 View MSA. No confident structure predictions are available.
    11 View Details [1528..2146] MSA 56.143897 View MSA. No confident structure predictions are available.
    12 View Details [2147..2233] deduced N/A No confident structure predictions are available.

    Functions predicted (by domain):

    # Gene Ontology predictions
    1
    Term Confidence Notes
  • acetyl-CoA carboxylase activity
    		•  7.97944928068929 bayes_pls_golite062009
  • CoA carboxylase activity
    		•  7.26031530137805 bayes_pls_golite062009
  • ligase activity, forming carbon-carbon bonds
    		•  7.11064677387039 bayes_pls_golite062009
  • biotin carboxylase activity
    		•  6.9547407447638 bayes_pls_golite062009
  • ligase activity
    		•  6.37416374794432 bayes_pls_golite062009
  • carbamoyl-phosphate synthase activity
    		•  4.25267317906061 bayes_pls_golite062009
  • carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
    		•  4.17451795830682 bayes_pls_golite062009
  • succinate-CoA ligase activity
    		•  3.60521632399322 bayes_pls_golite062009
  • CoA-ligase activity
    		•  3.23896308753196 bayes_pls_golite062009
  • acid-thiol ligase activity
    		•  3.04454283840859 bayes_pls_golite062009
  • methylcrotonoyl-CoA carboxylase activity
    		•  2.98357921316004 bayes_pls_golite062009
  • glutathione synthase activity
    		•  2.75320638765219 bayes_pls_golite062009
  • ligase activity, forming carbon-sulfur bonds
    		•  2.73831154716701 bayes_pls_golite062009
  • ligase activity, forming carbon-nitrogen bonds
    		•  1.74185999556024 bayes_pls_golite062009
  • glutathione binding
    		•  1.60917807172757 bayes_pls_golite062009
  • phosphoribosylaminoimidazole carboxylase activity
    		•  1.57708889650281 bayes_pls_golite062009
  • succinate-CoA ligase (ADP-forming) activity
    		•  1.55053478055591 bayes_pls_golite062009
  • binding
    		•  1.51238789441513 bayes_pls_golite062009
  • acid-amino acid ligase activity
    		•  1.40905042897991 bayes_pls_golite062009
  • transporter activity
    		•  1.29381792295125 bayes_pls_golite062009
  • carbon-nitrogen ligase activity, with glutamine as amido-N-donor
    		•  1.11645327303429 bayes_pls_golite062009
  • catalytic activity
    		•  1.08688404807699 bayes_pls_golite062009
  • phosphoribosylamine-glycine ligase activity
    		•  1.04915286326924 bayes_pls_golite062009
  • propionyl-CoA carboxylase activity
    		•  0.643677287269589 bayes_pls_golite062009
  • hydrolase activity
    		•  0.543813086594651 bayes_pls_golite062009
  • protein binding
    		•  0.455938814211606 bayes_pls_golite062009
  • succinate-CoA ligase (GDP-forming) activity
    		•  0.34559667514727 bayes_pls_golite062009
    2 No functions predicted.
    3 No functions predicted.
    4 No functions predicted.
    5 No functions predicted.
    6 No functions predicted.
    7 No functions predicted.
    8 No functions predicted.
    9 No functions predicted.
    10 No functions predicted.
    11 No functions predicted.
    12 No functions predicted.


    Reference: Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076


    Philius Transmembrane Prediction:

    Protein predicted to be: GLOBULAR (No transmembrane regions or signal peptide)
    Confidence of classification: 0.99

    Source: Reynolds et al. (2008)

    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle