YRC Logo
PROTEIN SEARCH:
Descriptions Names[Advanced Search]

Protein Overview: RNR2

General Information:
Name(s) found: RNR2 / YJL026W [SGD]
Description(s) found:
Found 35 descriptions.
SHOW ALL
  • Ribonucleotide-diphosphate reductase (RNR), small subunit; the RNR complex catalyzes the rate-limiting step in dNTP synthesis and is regulated by DNA replication and DNA damage checkpoint pathways via localization of the small subunits [SGD]
    • Organism: Saccharomyces cerevisiae
    Length: 399 amino acids

    Gene Ontology:
    Cellular Component: nucleus [IDALink to PubMed article]
    cytoplasm [IDALink to PubMed articleLink to PubMed article]
    ribonucleoside-diphosphate reductase complex [IDALink to PubMed article]
    Biological Process: DNA replication [TASLink to PubMed article]
    Molecular Function: ribonucleoside-diphosphate reductase activity [IDALink to PubMed article][ISSLink to PubMed article]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MPKETPSKAA ADALSDLEIK DSKSNLNKEL ETLREENRVK SDMLKEKLSK DAENHKAYLK  60
   61 SHQVHRHKLK EMEKEEPLLN EDKERTVLFP IKYHEIWQAY KRAEASFWTA EEIDLSKDIH 120
  121 DWNNRMNENE RFFISRVLAF FAASDGIVNE NLVENFSTEV QIPEAKSFYG FQIMIENIHS 180
  181 ETYSLLIDTY IKDPKESEFL FNAIHTIPEI GEKAEWALRW IQDADALFGE RLVAFASIEG 240
  241 VFFSGSFASI FWLKKRGMMP GLTFSNELIC RDEGLHTDFA CLLFAHLKNK PDPAIVEKIV 300
  301 TEAVEIEQRY FLDALPVALL GMNADLMNQY VEFVADRLLV AFGNKKYYKV ENPFDFMENI 360
  361 SLAGKTNFFE KRVSDYQKAG VMSKSTKQEA GAFTFNEDF

    Protein Complex Data

      PUBLICATION TOPOLOGY COCOMPLEXED PROTEINS
    View Details Riffle et al. (2010) (Unpublished Data) RNR1 RNR2 RNR4 WTM1
    View Details (MIPS) Mewes HW, et al. (2004) RNR1 RNR2 RNR3 RNR4
    View Details Krogan NJ, et al. (2006) RNR1 RNR2 RNR3 RNR4
    View Details Gavin AC, et al. (2006) RNR2 RNR4
    View Details Gavin AC, et al. (2002) ADE5,7 ASF1 HHF1, HHF2 HIR3 IOC3 ISW1 ISW2 ITC1 MAM33 MOT1 NPL6 RAD53 REB1 RFA1 RFX1 RNR2 RNR4 RPC34 RPC40 RPO31 RSC2 RSC3 RSC58 RSC8 RVB2 SFH1 STH1 STO1 TAF1 TFC7 TOP1 VPS1 YBR090C-A, NHP6B
    View Details Ho Y, et al. (2002) AAT2 ACC1 ACH1 ACO1 ADH6 ADO1 AFR1 AHP1 ARC1 ARF1 ARG4 ARP2 ATP3 AYR1 BFA1 BGL2 CAR2 CCT6 CDC15 CDC33 CLU1 COF1 COR1 CPA2 CPR1 CPR6 CYR1 CYS4 DBP8 DUG2 EGD1 ERG13 ERG27 ERG6 FAA1 FAA4 FPR1 FRS2 FUM1 GAS1 GLT1 GND1 GND2 GPT2 GRX1 GSF2 GUS1 HEF3 HHF1, HHF2 ILV5 KGD1 LIA1 LRO1 LSP1 MAE1 MET6 NDE1 NPA3 NTF2 NUP53 OLA1 OM45 OYE2 PCT1 PDA1 PET10 PET9 PFK1 PFK2 PGM2 PIL1 PRE10 PRM2 PRO1 PRO3 RAD1 RAD10 RET2 RMT2 RNR1 RNR2 RPN1 RPT4 RSN1 RTN2 RVB1 RVS161 SAH1 SAP155 SAP185 SAP190 SCP160 SEC18 SEC21 SEC26 SEC27 SEC28 SEC53 SEN15 SES1 SGD1 SIR1 SIR3 SIT4 SMK1 SNU13 SOD1 SRV2 SSD1 SWD1 TAP42 TEF4 TEM1 TFP1 THI22 THS1 TIF1, TIF2 TIF34 TIF35 TMA19 TMA29 TPA1 TSA2 UBA1 UBI4 UTP5 VMA4 VMA5 WTM1 WTM2 YDL086W YER138C YMR196W YNK1 YNL181W YOR283W YTM1
    View Details Qiu et al. (2008) RNR1 RNR2 RNR3 RNR4

    Mass Spectrometry Data

    The following runs contain data for this protein:

      BAIT COMMENTS PUBLICATION
    View Run MLP2 #25 Asynchronous Prep3-TiO2 Flowthrough Keck JM, et al. (2011)
    View Run MLP2 #32 Asynchronous Prep-No Phosphopeptide enrichment Keck JM, et al. (2011)

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    SHOWING SINGLE HITS. [ Hide Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

    No yeast two-hybrid interactions found for this protein.

    Microscopy / Localization Data

    New Feature: Upload Your Own Microscopy Data

      PROTEIN(S) PUBLICATION
    View Data RNR2 Huh WK, et al. (2003)

    Protein Structure Data


    [What does the above image mean?]
    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..399] PSI-BLAST 10143.0 Ribonucleotide reductase R2

    Functions predicted (by domain):

    # Gene Ontology predictions
    1
    Term Confidence Notes
  • oxidoreductase activity, acting on CH or CH2 groups, disulfide as acceptor
    		•  12.7205287868529 bayes_pls_golite062009
  • ribonucleoside-diphosphate reductase activity
    		•  12.6679910771829 bayes_pls_golite062009
  • oxidoreductase activity, acting on CH or CH2 groups
    		•  12.0783326936172 bayes_pls_golite062009
  • class I ribonucleotide reductase activity
    		•  7.27682621818194 bayes_pls_golite062009
  • oxidoreductase activity
    		•  2.7065388366096 bayes_pls_golite062009
  • binding
    		•  2.38747290927526 bayes_pls_golite062009
  • nucleic acid binding
    		•  1.65619019230429 bayes_pls_golite062009
  • DNA binding
    		•  1.60520679245579 bayes_pls_golite062009
  • protein binding
    		•  1.35559475972187 bayes_pls_golite062009
  • ion binding
    		•  0.214820110894452 bayes_pls_golite062009
  • cation binding
    		•  0.203880627974907 bayes_pls_golite062009
  • metal ion binding
    		•  0.203880627974907 bayes_pls_golite062009
  • catalytic activity
    		•  0.197328811494233 bayes_pls_golite062009
  • transition metal ion binding
    		•  0.168785605665701 bayes_pls_golite062009


    Reference: Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076


    Philius Transmembrane Prediction:

    Protein predicted to be: GLOBULAR (No transmembrane regions or signal peptide)
    Confidence of classification: 0.45

    Source: Reynolds et al. (2008)

    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle