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Protein Overview: ISW1

General Information:
Name(s) found: ISW1 / YBR245C [SGD]
Description(s) found:
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  • gi|6319722|ref|NP_009804.1| Member of the imitation-switch (ISWI) class of ATP-dependent chromatin remodeling complexes; ATPase that forms a complex with Ioc2p and Ioc4p to regulate transcription elongation, and a complex with Ioc3p to repress transcripti [NCBI NR]
  • gi|2506238|sp|P38144.2|ISW1_YEAST RecName: Full=ISWI chromatin-remodeling complex ATPase ISW1 [NCBI NR]
  • gi|1872131|emb|CAA85208.1| unnamed protein product [Saccharomyces cerevisiae] [NCBI NR]
  • (P38144) Hypothetical 131.1 kDa helicase in ALG7-ENP1 intergenic region [Swiss-Prot]
  • ISWI chromatin-remodeling complex ATPase ISW1 OS=Saccharomyces cerevisiae GN=ISW1 PE=1 SV=2 [Swiss-Prot]
  • ISW1 ATPase component of a four subunit chromatin remodeling complex [mips]
  • Member of the imitation-switch (ISWI) class of ATP-dependent chromatin remodeling complexes; ATPase that forms a complex with Ioc2p and Ioc4p to regulate transcription elongation, and a complex with Ioc3p to repress transcription initiation [SGD]
  • ISW1, Chr II from 708108-711497, reverse complement [yeast_orfs2]
  • Chr II from 708108-711497, reverse complement [yeastorf3.fasta]
  • Chr II from 708107-711496, reverse complement [yeastorf4.fasta]
  • Chr II from 711494-708105, reverse complement [yeastorf5.fasta]
  • ISW1 SGDID:S0000449, Chr II from 711496-708107, reverse complement, Verified ORF [yeastflysequest.fasta]
  • ISW1 SGDID:S0000449, Chr II from 711534-708145, reverse complement, Verified ORF [10112005cervSGD.fasta]
  • Isw1p [Saccharomyces cerevisiae]gi|1872131|emb|CAA85208.1| unnamed protein product [Saccharomyces cerevisiae]gi|2506238|sp|P38144|YB95_YEAST Hypothetical 131.1 kDa helicase in ALG7-ENP1 intergenic region [nrdb_11152004_Chlamydomonas]
  • ISW1 SGDID:S000000449, Chr II from 711534-708145, reverse complement, Verified ORF, "Member of the imitation-switch (ISWI) class of ATP-dependent chromatin remodeling complexes; ATPase that forms a complex with Ioc2p and Ioc4p to regulate transcription el [SGD_S-cerevisiae_na_12-16-2005_con_reversed.fasta]
  • unnamed protein product [Saccharomyces cerevisiae] [nr-271106-contam.fasta]
  • Member of the imitation-switch (ISWI) class of ATP-dependent chromatin remodeling complexes; ATPase that forms a complex with Ioc2p and Ioc4p to regulate transcription elongation, and a complex with Ioc3p to repress transcription initiation; Isw1p [Saccha [nr-271106-contam.fasta]
  • ISWI chromatin remodeling complex ATPase ISW1 [nr-271106-contam.fasta]
  • ISW1 SGDID:S000000449, Chr II from 711534-708145, reverse complement, Verified ORF, "Member of the imitation-switch (ISWI) class of ATP-dependent chromatin remodeling complexes; ATPase that forms a complex with Ioc2p and Ioc4p to regulate transcription elongation, and a complex with Ioc3p to repress transcription initiation" [yeast-bovrabprots.fasta]
  • [chemostatdb.fasta]
  • ISWI chromatin-remodeling complex ATPase ISW1 OS=Saccharomyces cerevisiae (strain ATCC 204508 / S288c) GN=ISW1 PE=1 SV=2 [UniProt_S_cerevisiae_20120516_05-16-2012_reversed.fasta]
  • ISW1 SGDID:S000000449, Chr II from 711539-708150, Genome Release 64-1-1, reverse complement, Verified ORF, "Member of the imitation-switch (ISWI) class of ATP-dependent chromatin remodeling complexes; ATPase that forms a complex with Ioc2p and Ioc4p to regulate transcription elongation, and a complex with Ioc3p to repress transcription initiation" [yeast-030211-contam.fasta]
  • ISW1 SGDID:S000000449, Chr II from 711539-708150, Genome Release 64-2-1, reverse complement, Verified ORF, "ATPase subunit of imitation-switch (ISWI) class chromatin remodelers; with Ioc3p forms Isw1a complex involved in repression of transcription initiation; with Ioc2p and Ioc4p forms Isw1b complex involved in regulation of transcription elongation; Isw1b recruited to ORFs by H3K36 methylation and acts with Chd1p to prevent trans-histone exchange over coding regions; Isw1p import into nucleus depends on C-terminal bipartite nuclear targeting signal KRIR X19 KKAK" [20141208_orf_trans.fasta]
  • YBR245C SGDID:S000000449, Chr II from 711539-708150, Genome Release 64-1-1, reverse complement, Verified ORF, "Member of the imitation-switch (ISWI) class of ATP-dependent chromatin remodeling complexes; ATPase that forms a complex with Ioc2p and Ioc4p to regulate transcription elongation, and a complex with Ioc3p to repress transcription initiation" [2016-01-SGD_Yeast_Contam_Riffle_20140507-Ska-Hec-110-tubulin.fasta]
    • Organism: Saccharomyces cerevisiae
    Length: 1129 amino acids

    Gene Ontology:
    Cellular Component: ISW1 complex [IPILink to PubMed article]
    Biological Process: chromatin remodeling [IGILink to PubMed article][IMPLink to PubMed article][IPILink to PubMed article]
    RNA elongation [IDALink to PubMed article][IMPLink to PubMed article]
    Molecular Function: ATPase activity [ISSLink to PubMed article][TASLink to PubMed article]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MAYMLAIANF HFFKFYTRMR KKHENNSCNE KDKDENLFKI ILAIFLQEKK KYDCISSGSI  60
   61 MTASEEYLEN LKPFQVGLPP HDPESNKKRY LLKDANGKKF DLEGTTKRFE HLLSLSGLFK 120
  121 HFIESKAAKD PKFRQVLDVL EENKANGKGK GKHQDVRRRK TEHEEDAELL KEEDSDDDES 180
  181 IEFQFRESPA YVNGQLRPYQ IQGVNWLVSL HKNKIAGILA DEMGLGKTLQ TISFLGYLRY 240
  241 IEKIPGPFLV IAPKSTLNNW LREINRWTPD VNAFILQGDK EERAELIQKK LLGCDFDVVI 300
  301 ASYEIIIREK SPLKKINWEY IIIDEAHRIK NEESMLSQVL REFTSRNRLL ITGTPLQNNL 360
  361 HELWALLNFL LPDIFSDAQD FDDWFSSEST EEDQDKIVKQ LHTVLQPFLL RRIKSDVETS 420
  421 LLPKKELNLY VGMSSMQKKW YKKILEKDLD AVNGSNGSKE SKTRLLNIMM QLRKCCNHPY 480
  481 LFDGAEPGPP YTTDEHLVYN AAKLQVLDKL LKKLKEEGSR VLIFSQMSRL LDILEDYCYF 540
  541 RNYEYCRIDG STAHEDRIQA IDDYNAPDSK KFVFLLTTRA GGLGINLTSA DVVVLYDSDW 600
  601 NPQADLQAMD RAHRIGQKKQ VKVFRLVTDN SVEEKILERA TQKLRLDQLV IQQNRTSLKK 660
  661 KENKADSKDA LLSMIQHGAA DVFKSGTSTG SAGTPEPGSG EKGDDIDLDE LLLKSENKTK 720
  721 SLNAKYETLG LDDLQKFNQD SAYEWNGQDF KKKIQRDIIS PLLLNPTKRE RKENYSIDNY 780
  781 YKDVLNTGRS STPSHPRMPK PHVFHSHQLQ PPQLKVLYEK ERMWTAKKTG YVPTMDDVKA 840
  841 AYGDISDEEE KKQKLELLKL SVNNSQPLTE EEEKMKADWE SEGFTNWNKL EFRKFITVSG 900
  901 KYGRNSIQAI ARELAPGKTL EEVRAYAKAF WSNIERIEDY EKYLKIIENE EEKIKRVKMQ 960
  961 QEALRRKLSE YKNPFFDLKL KHPPSSNNKR TYSEEEDRFI LLMLFKYGLD RDDVYELVRD1020
 1021 EIRDCPLFEL DFYFRSRTPV ELARRGNTLL QCLEKEFNAG IVLDDATKDR MKKEDENGKR1080
 1081 IREEFADQTA NEKENVDGVE SKKAKIEDTS NVGTEQLVAE KIPENETTH

    Protein Complex Data

      PUBLICATION TOPOLOGY COCOMPLEXED PROTEINS
    View Details Riffle et al. (2010) (Unpublished Data) ACT1 HHF1, HHF2 HTA2 IOC2 IOC3 ISW1 ISW2 ITC1 MOT1 RET1 RSC2 RSC3 RSC58 RSC8 STH1 VPS1
    View Details Krogan NJ, et al. (2006) ESC8 IOC2 IOC3 IOC4 ISW1 YJL068C
    View Details Gavin AC, et al. (2006) IOC3 ISW1
    View Details Gavin AC, et al. (2002) ABF2 ACT1 ADE5,7 ADH1 ARP4 ARP8 CAB3 CHD1 CKA1 CKA2 CKB1 CKB2 CTI6 DEP1 DIS3 DOT6 DPB2 DPB4 EAF3 ECM16 ESC8 GCN1 HHF1, HHF2 HOT1 HTA2 IES1 IES5 INO80 IOC3 ISW1 ISW2 ITC1 KAP114 MAS1 MAS2 MED4 MOT1 NAP1 NHP10 NIP1 NPL6 NRD1 PDC1 PFK2 PHO23 POL2 PRT1 PUF6 RCO1 REB1 RET1 RFA1 RFX1 RNR2 RPA135 RPC34 RPC40 RPC82 RPD3 RPG1 RPN9 RPO31 RPT5 RRP4 RSC2 RSC3 RSC4 RSC58 RSC6 RSC8 RVB2 RXT2 RXT3 SAP30 SDS3 SFH1 SIN3 SMC4 SPT15 SPT16 SSA4 STH1 STO1 TAF1 TAF5 TAF6 TFC7 TIF35 TOP1 TUP1 UME1 UME6 UTP22 VPS1 YBR090C-A, NHP6B YEF3 YTA7
    View Details Ho Y, et al. (2002) ISW1 ISW2 KAP95

    Mass Spectrometry Data

    The following runs contain data for this protein:

      BAIT COMMENTS PUBLICATION
    View Run CEP3 sample cbf3 from feb 2005 Sandall S, et all (2006)
    View Run MLP2 #26 Asynchronous Prep4-TiO2 Phosphopeptide enriched, Steps1-2 Keck JM, et al. (2011)

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    NOT SHOWING SINGLE HITS. [ Show Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

    No yeast two-hybrid interactions found for this protein.

    Microscopy / Localization Data

    New Feature: Upload Your Own Microscopy Data

      PROTEIN(S) PUBLICATION
    View Data ISW1 Huh WK, et al. (2003)

    Protein Structure Data


    [What does the above image mean?]
    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..122] MSA 1.231996 View MSA. Confident ab initio structure predictions are available.
    2 View Details [123..375] PSI-BLAST 4.69897 RecG, N-terminal domain; RecG "wedge" domain; RecG helicase domain
    3 View Details [376..433] deduced N/A No confident structure predictions are available.
    4 View Details [434..618] PSI-BLAST 11.154902 Putative DEAD box RNA helicase
    5 View Details [619..990] MSA 3.688996 View MSA. No confident structure predictions are available.
    6 View Details [991..1129] deduced N/A No confident structure predictions are available.

    Functions predicted (by domain):

    # Gene Ontology predictions
    1 No functions predicted.
    2
    Term Confidence Notes
  • general RNA polymerase II transcription factor activity
    		•  3.1726526166851 bayes_pls_golite062009
  • binding
    		•  2.64537357529343 bayes_pls_golite062009
  • nucleic acid binding
    		•  2.51683451033161 bayes_pls_golite062009
  • DNA binding
    		•  2.12258000781149 bayes_pls_golite062009
  • transcription regulator activity
    		•  2.09345198747025 bayes_pls_golite062009
  • structural constituent of ribosome
    		•  1.47858140861683 bayes_pls_golite062009
  • DNA-dependent ATPase activity
    		•  1.23094623498843 bayes_pls_golite062009
  • protein binding
    		•  1.22129154759482 bayes_pls_golite062009
  • purine ribonucleotide binding
    		•  1.21658213854831 bayes_pls_golite062009
  • ribonucleotide binding
    		•  1.21652144153182 bayes_pls_golite062009
  • purine nucleotide binding
    		•  1.21571071905795 bayes_pls_golite062009
  • nucleotide binding
    		•  1.20347573865566 bayes_pls_golite062009
  • motor activity
    		•  1.14667913749579 bayes_pls_golite062009
  • transcription elongation regulator activity
    		•  1.11383295816593 bayes_pls_golite062009
  • lysine N-acetyltransferase activity
    		•  1.05990253628867 bayes_pls_golite062009
  • histone acetyltransferase activity
    		•  1.05990253628867 bayes_pls_golite062009
  • catalytic activity
    		•  1.00104173493322 bayes_pls_golite062009
  • transcription activator activity
    		•  0.889929694023098 bayes_pls_golite062009
  • transcription factor activity
    		•  0.887108427603557 bayes_pls_golite062009
  • structural molecule activity
    		•  0.86514677273731 bayes_pls_golite062009
  • transcription repressor activity
    		•  0.862685397469217 bayes_pls_golite062009
  • protein-DNA loading ATPase activity
    		•  0.729056749897011 bayes_pls_golite062009
  • steroid hormone receptor binding
    		•  0.647625526012423 bayes_pls_golite062009
  • structure-specific DNA binding
    		•  0.620212706423176 bayes_pls_golite062009
  • helicase activity
    		•  0.6191010101321 bayes_pls_golite062009
  • microtubule motor activity
    		•  0.60036517876321 bayes_pls_golite062009
  • DNA helicase activity
    		•  0.57378485697982 bayes_pls_golite062009
  • sequence-specific DNA binding
    		•  0.543891899378373 bayes_pls_golite062009
  • cytoskeletal protein binding
    		•  0.500462538667228 bayes_pls_golite062009
  • DNA clamp loader activity
    		•  0.49811753387851 bayes_pls_golite062009
  • double-stranded DNA binding
    		•  0.49000746592281 bayes_pls_golite062009
  • guanyl nucleotide binding
    		•  0.388587892299301 bayes_pls_golite062009
  • guanyl ribonucleotide binding
    		•  0.372638007722845 bayes_pls_golite062009
  • GTP binding
    		•  0.364508542344128 bayes_pls_golite062009
  • hormone receptor binding
    		•  0.351501100511918 bayes_pls_golite062009
  • centromeric DNA binding
    		•  0.322818640526369 bayes_pls_golite062009
  • ATP-dependent helicase activity
    		•  0.29664013896754 bayes_pls_golite062009
  • purine NTP-dependent helicase activity
    		•  0.29664013896754 bayes_pls_golite062009
  • translation regulator activity
    		•  0.29096092258568 bayes_pls_golite062009
  • translation factor activity, nucleic acid binding
    		•  0.274994961137851 bayes_pls_golite062009
  • ATP-dependent DNA helicase activity
    		•  0.24825301806267 bayes_pls_golite062009
  • nuclear hormone receptor binding
    		•  0.246160342138071 bayes_pls_golite062009
  • RNA polymerase II transcription factor activity
    		•  0.243902356228423 bayes_pls_golite062009
  • GTPase activity
    		•  0.234351968078991 bayes_pls_golite062009
  • ATP binding
    		•  0.1860481660648 bayes_pls_golite062009
  • RNA helicase activity
    		•  0.18426050934025 bayes_pls_golite062009
  • adenyl ribonucleotide binding
    		•  0.152859582615242 bayes_pls_golite062009
  • nucleoside-triphosphatase activity
    		•  0.147579541298736 bayes_pls_golite062009
  • RNA-dependent ATPase activity
    		•  0.14606996093053 bayes_pls_golite062009
  • adenyl nucleotide binding
    		•  0.138615225841109 bayes_pls_golite062009
  • pyrophosphatase activity
    		•  0.133017653323467 bayes_pls_golite062009
  • ATP-dependent RNA helicase activity
    		•  0.13050483816765 bayes_pls_golite062009
  • hydrolase activity, acting on acid anhydrides
    		•  0.113504049290503 bayes_pls_golite062009
  • hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides
    		•  0.111293884322157 bayes_pls_golite062009
  • actin binding
    		•  0.00482938540552702 bayes_pls_golite062009
    3 No functions predicted.
    4 No functions predicted.
    5 No functions predicted.
    6 No functions predicted.


    Reference: Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076


    Philius Transmembrane Prediction:

    Protein predicted to be: GLOBULAR (No transmembrane regions or signal peptide)
    Confidence of classification: 0.99

    Source: Reynolds et al. (2008)

    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle