Protein Overview: NOG2

General Information:
Name(s) found:	NOG2 / YNR053C [SGD]
Description(s) found: SHOW ONLY BEST	gi\|6324381\|ref\|NP_014451.1\| Putative GTPase that associates with pre-60S ribosomal subunits in the nucleolus and is required for their nuclear export and maturation; Nog2p [Saccharomyces cerevisiae] [NCBI NR] pir\|\|S63384 hypothetical protein YNR053c - yeast (Saccharomyces cerevisiae) [NCBI NR] gi\|1730685\|sp\|P53742.1\|NOG2_YEAST RecName: Full=Nucleolar GTP-binding protein 2 [NCBI NR] gi\|1302570\|emb\|CAA96334.1\| unnamed protein product [Saccharomyces cerevisiae] [NCBI NR] Nucleolar GTP-binding protein 2 OS=Saccharomyces cerevisiae GN=NOG2 PE=1 SV=1 [Swiss-Prot] NOG2 Putative GTPase that associates with pre-60S ribosomal subunits in the nucleolus and is required for their nuclear export and maturation [mips] Putative GTPase that associates with pre-60S ribosomal subunits in the nucleolus and is required for their nuclear export and maturation [SGD] (P53742) Hypothetical GTP-binding protein in POP2-HOL1 intergenic region [4932.FASTACCERV.txt] Chr XIV from 723108-722299,721767-721117, reverse complement [hmr_yeast5_DM3-1_pombe.fasta] Chr XIV from 721117-721926,722458-723108, reverse complement [yeastorf3.fasta] YNR053C, Chr XIV from 721117-721926,722458-723108, reverse complement [yeast_orfs2] NOG2 SGDID:S0005336, Chr XIV from 723110-722301,721769-721119, reverse complement, Verified ORF [yeastflysequest.fasta] NOG2 SGDID:S0005336, Chr XIV from 723111-722302,721770-721120, reverse complement, Verified ORF [10112005cervSGD.fasta] Nog2p [Saccharomyces cerevisiae]gi\|1302570\|emb\|CAA96334.1\| unnamed protein product [Saccharomyces cerevisiae]gi\|2131978\|pir\|\|S63384 hypothetical protein YNR053c - yeast (Saccharomyces cerevisiae)gi\|1730685\|sp\|P53742\|NOG2_YEAST Nucleolar GTP-binding pro [nrdb_11152004_Chlamydomonas] (P53742) Nucleolar GTP-binding protein 2 [cerv4932.FASTAC] NOG2 SGDID:S000005336, Chr XIV from 723113-722304,721772-721122, reverse complement, Verified ORF, "Putative GTPase that associates with pre-60S ribosomal subunits in the nucleolus and is required for their nuclear export and maturation" [SGD_S-cerevisiae_na_12-16-2005_con_reversed.fasta] Putative GTPase that associates with pre-60S ribosomal subunits in the nucleolus and is required for their nuclear export and maturation; Nog2p [Saccharomyces cerevisiae] [nr-271106-contam.fasta] Nucleolar GTP-binding protein 2 [nr-271106-contam.fasta] unnamed protein product [Saccharomyces cerevisiae] [nr-271106-contam.fasta] NOG2 SGDID:S000005336, Chr XIV from 723114-722305,721773-721123, reverse complement, Verified ORF, "Putative GTPase that associates with pre-60S ribosomal subunits in the nucleolus and is required for their nuclear export and maturation" [SGD_S-cerevisiae_na_01-05-2010_reversed.fasta] [chemostatdb.fasta] Nucleolar GTP-binding protein 2 OS=Saccharomyces cerevisiae (strain ATCC 204508 / S288c) GN=NOG2 PE=1 SV=1 [UniProt_S_cerevisiae_20120516_05-16-2012_reversed.fasta] NOG2 SGDID:S000005336, Chr XIV from 721770-721120,723112-722303, Genome Release 64-1-1, reverse complement, Verified ORF, "Putative GTPase that associates with pre-60S ribosomal subunits in the nucleolus and is required for their nuclear export and maturation" [yeast-030211-contam.fasta] NOG2 SGDID:S000005336, Chr XIV from 721770-721120,723112-722303, Genome Release 64-2-1, reverse complement, Verified ORF, "Putative GTPase; associates with pre-60S ribosomal subunits in the nucleolus and is required for their nuclear export and maturation" [20141208_orf_trans.fasta] YNR053C SGDID:S000005336, Chr XIV from 721770-721120,723112-722303, Genome Release 64-1-1, reverse complement, Verified ORF, "Putative GTPase that associates with pre-60S ribosomal subunits in the nucleolus and is required for their nuclear export and maturation" [2016-01-SGD_Yeast_Contam_Riffle_20140507-Ska-Hec-110-tubulin.fasta]
Organism:	Saccharomyces cerevisiae
Length:	486 amino acids
Gene Ontology:
Cellular Component:	nucleus [IDA] nucleolus [IDA] nucleoplasm [IDA]
Biological Process:	ribosomal large subunit export from nucleus [IMP][IPI] ribosome biogenesis [RCA] ribosome assembly [TAS]
Molecular Function:	GTPase activity [TAS]

Sequence:

Sequence:
[PDR BLAST]
[ProtParam]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MGTGKKEKSR RIREGDTKDG NLRVKGENFY RDSKRVKFLN MYTSGKEIRN KKGNLIRAAS  60
   61 FQDSTIPDAR VQPDRRWFGN TRVISQDALQ HFRSALGETQ KDTYQVLLRR NKLPMSLLEE 120
  121 KDADESPKAR ILDTESYADA FGPKAQRKRP RLAASNLEDL VKATNEDITK YEEKQVLDAT 180
  181 LGLMGNQEDK ENGWTSAAKE AIFSKGQSKR IWNELYKVID SSDVVIHVLD ARDPLGTRCK 240
  241 SVEEYMKKET PHKHLIYVLN KCDLVPTWVA AAWVKHLSKE RPTLAFHASI TNSFGKGSLI 300
  301 QLLRQFSQLH TDRKQISVGF IGYPNTGKSS IINTLRKKKV CQVAPIPGET KVWQYITLMK 360
  361 RIFLIDCPGI VPPSSKDSEE DILFRGVVRV EHVTHPEQYI PGVLKRCQVK HLERTYEISG 420
  421 WKDATEFIEI LARKQGRLLK GGEPDESGVS KQILNDFNRG KIPWFVLPPE KEGEEKPKKK 480
  481 EVEKTA

Protein Complex Data

	PUBLICATION	TOPOLOGY	COCOMPLEXED PROTEINS
View Details	Riffle et al. (2010) (Unpublished Data)		ARX1 BUD20 CIC1 DBP10 ERB1 HAS1 IPI1 IPI3 LSG1 MDN1 MRT4 NIP7 NOC3 NOG1 NOG2 NOP15 NOP7 NSA2 NUG1 PUF6 RIX1 RLP7 RPF2 RPL25 RPL27A RPL36B RPL38 RSA4 SDA1 TIF6
View Details	Krogan NJ, et al. (2006)		NOG1 NOG2 NOP15 NUG1 YSW1
View Details	Gavin AC, et al. (2006)		ARX1 BUD20 FPR4 IPI3 MRT4 NIP7 NOG1 NOG2 NOP2 NSA2 NUG1 RIX1 RPF2 RSA4 SDA1 TIF6
View Details	Gavin AC, et al. (2002)		ARC15 ARC18 ARC19 ARC35 ARC40 ARP2 ARP3 ARX1 ASC1 BEM2 BMS1 BRX1 BUD20 CCT5 CCT8 CDC33 CIC1 CLF1 CLU1 CWC23 CYR1 CYS4 DBP10 DBP9 DCP2 DHH1 DIB1 DRS1 EBP2 ERB1 FPR4 GCN1 HAS1 HDA1 HER1 HIS3 INP2 IPI1 IPI3 KRE33 KRS1 LHP1 LOC1 LSG1 LSM1 LSM2 LSM3 LSM4 LSM5 LSM6 LSM7 MAK21 MAK5 MDN1 MIS1 MRT4 NAM7 NAP1 NIP1 NIP7 NMD3 NOC2 NOC3 NOG1 NOG2 NOP1 NOP12 NOP15 NOP16 NOP2 NOP4 NOP56 NOP7 NSA1 NSA2 NUG1 PAT1 PFK1 PRP24 PRP31 PRP38 PRP4 PRP43 PRP46 PRP6 PRT1 PUF6 REI1 RIX1 RIX7 RLP24 RLP7 RPA135 RPA190 RPF1 RPF2 RPG1 RPP2B RPT6 RRP1 RRP12 RSA3 RSA4 RTR1 SDA1 SEC7 SKI2 SMB1 SMD2 SNU114 SNU13 SNU23 SNU66 SPB1 SPB4 SPP382 SQS1 SRO9 SSF1 TIF6 TUB3 URB1 UTP10 UTP20 UTP22 YGL036W YTM1
View Details	Ho Y, et al. (2002)		ATP3 AVO1 CCT5 CLU1 DHH1 DPB2 FUN12 GAL7 GPH1 IDH1 ILV2 MET16 MKK2 NOG2 NPA3 PDX1 PHO85 PUF3 RPN12 SIS1 SLX1 SRP54 STI1 TEM1 TFC7 VMA8 YER077C YGR266W YKR051W YKU80 YLR271W YPR003C
View Details	Qiu et al. (2008)		AIR1 DBP3 DRS1 MAK5 NOG2 NUG1 RIX7 RNT1 ROK1 SPB4

Mass Spectrometry Data

No mass spectrometry results found for this protein.

Yeast Two-Hybrid Data

The following interactions contain this protein:

SHOWING SINGLE HITS. [ Hide Single Hits ]

[View our yeast two-hybrid interpretation guidelines.]

	BAIT	PREY	HITS	PUBLICATION
View Screen	UBC7	NOG2	1	Unpublished Fields Lab Data
View Screen	PHO85	NOG2	1	Unpublished Fields Lab Data

Microscopy / Localization Data

New Feature: Upload Your Own Microscopy Data

	PROTEIN(S)	PUBLICATION
View Data	NOG2	Huh WK, et al. (2003)

Protein Structure Data

[What does the above image mean?]
[View Top Sequence Alignments] [Show Ginzu Version Information]

Domains predicted:

#		Region(s)	Method	Confidence	Match Description
1	View Details	[1..112]	MSA	1.205968	View MSA. No confident structure predictions are available.
2	View Details	[113..312]	PSI-BLAST	4.522879	cH-p21 Ras protein
3	View Details	[313..486]	PSI-BLAST	31.0	GTPase Era, N-terminal domain; GTPase Era C-terminal domain

Reference: Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076

Philius Transmembrane Prediction:

Protein predicted to be:	GLOBULAR (No transmembrane regions or signal peptide)
Confidence of classification:	0.99

Source: Reynolds et al. (2008)

TMHMM	2.0c	PSIPRED	v2.61
SignalP	3.0	COILS	1999
DISOPRED	v0.1	NCBI nr	06/2007
PSI-BLAST	2.2.18	FFAS	ffas03
PDB	06/2007	Pfam	22
HMMER	2.3.2