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Protein Overview: DBP9

General Information:
Name(s) found: DBP9 / YLR276C [SGD]
Description(s) found:
Found 25 descriptions.
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  • ATP-dependent RNA helicase of the DEAD-box family involved in biogenesis of the 60S ribosomal subunit [SGD]
    • Organism: Saccharomyces cerevisiae
    Length: 594 amino acids

    Gene Ontology:
    Cellular Component: nuclear outer membrane [IMPLink to PubMed article][IPILink to PubMed article][TASLink to PubMed article]
    nucleolus [TASLink to PubMed article]
    Biological Process: ribosome biogenesis [RCALink to PubMed article]
    ribosomal large subunit assembly [IMPLink to PubMed article]
    Molecular Function: ATP-dependent RNA helicase activity [TASLink to PubMed article]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MSYEKKSVEG AYIDDSTTFE AFHLDSRLLQ AIKNIGFQYP TLIQSHAIPL ALQQKRDIIA  60
   61 KAATGSGKTL AYLIPVIETI LEYKKTIDNG EENGTLGIIL VPTRELAQQV YNVLEKLVLY 120
  121 CSKDIRTLNI SSDMSDSVLS TLLMDQPEII VGTPGKLLDL LQTKINSISL NELKFLVVDE 180
  181 VDLVLTFGYQ DDLNKIGEYL PLKKNLQTFL MSATLNDDIQ ALKQKFCRSP AILKFNDEEI 240
  241 NKNQNKLLQY YVKVSEFDKF LLCYVIFKLN LIKGKTLIFV NNIDRGYRLK LVMEQFGIKS 300
  301 CILNSELPVN SRQHIVDQFN KNVYQLLIAT DDTEYIKEED DEIEEGHNTE NQEEKSLEGE 360
  361 PENDKKPSKK KKVQVKKDKE YGVSRGVDFK NVACVLNFDL PTTAKSYVHR VGRTARGGKT 420
  421 GTAISFVVPL KEFGKHKPSM LQTAKKDERI LSRIIKQQSK LGLELQPYKF DQKQVEAFRY 480
  481 RMEDGFRAVT QVAIREARVK ELKQELLASE KLKRHFEENP KELQSLRHDK ELHPARVQQH 540
  541 LKRVPDYLLP ESARGNGTKV KFVPFHNAKK RHSHKKGRVS KPKNGKVDPL KNFK

    Protein Complex Data

      PUBLICATION TOPOLOGY COCOMPLEXED PROTEINS
    View Details Riffle et al. (2010) (Unpublished Data) BRX1 CIC1 DBP10 DBP9 DRS1 EBP2 ERB1 HAS1 MAK21 MAK5 NIP7 NOC2 NOG1 NOP2 NOP4 NOP7 NSA1 NUG1 PUF6 RLP7 RPL1A, RPL1B RPL25 RRP12 SLX9 URB1 YTM1
    View Details Krogan NJ, et al. (2006) ALB1 ARX1 DBP9 GLE2 PSE1 RAD27 SLX9 THO1
    View Details Gavin AC, et al. (2006) DBP10 DBP9 MAK21 MAK5 NOP13 NOP4 PUF6 RLP7 RSA3 SPA2 YMR310C YTM1
    View Details Gavin AC, et al. (2002) AAR2 ARX1 BEM2 BLM10 BMS1 BRX1 BUD20 CBF5 CIC1 CLU1 CYR1 CYS4 DAM1 DBP10 DBP9 DCP2 DRS1 EBP2 ECM29 ERB1 EST3 FPR4 FUN12 GAR1 GCN1 GFA1 HAS1 HDA1 HER1 HIS3 INO4 INP2 IPI1 IPI3 KAP95 KRE33 KRR1 LHP1 LOC1 LSG1 LYS12 MAK21 MAK5 MDN1 MDS3 MIS1 MRP7 MRT4 NAP1 NHP2 NIP1 NIP7 NMD3 NOC2 NOC3 NOG1 NOG2 NOP1 NOP12 NOP15 NOP16 NOP2 NOP4 NOP56 NOP6 NOP7 NSA1 NSA2 NUD1 NUG1 PDA1 PDB1 POL2 PRE10 PRE2 PRE3 PRE4 PRE5 PRE6 PRE8 PRE9 PRP4 PRT1 PSE1 PUF6 PUP3 REI1 RGR1 RIX1 RIX7 RLP24 RLP7 RPA135 RPA190 RPF1 RPF2 RPG1 RPP2B RPT3 RPT5 RPT6 RRP1 RRP12 RSA3 RSA4 RTR1 SCL1 SDA1 SEC7 SKI2 SLX9 SMB1 SNU114 SNU13 SNU66 SPA2 SPB1 SPB4 SRO9 SRP1 SSF1 TIF4631 TIF4632 TIF6 TUB3 ULP1 URB1 UTP10 UTP20 UTP21 UTP22 YFL006W YGL036W YMR310C YRA1 YTM1
    View Details Ho Y, et al. (2002) CDC9 DBP9 ECM10 POL30 YOR378W
    View Details Qiu et al. (2008) DBP3 DBP6 DBP9 DHR2 DRS1 MAK5 ROK1 RRP3 SPB4

    Mass Spectrometry Data

    The following runs contain data for this protein:

      BAIT COMMENTS PUBLICATION
    View Run MLP2 #24 Asynchronous Prep3-TiO2 Phosphopeptide enrichment Keck JM, et al. (2011)
    View Run MLP2 #32 Asynchronous Prep-No Phosphopeptide enrichment Keck JM, et al. (2011)
    View Run MLP2 #12 Mitotic Prep1-TiO2 Flowthrough Keck JM, et al. (2011)

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    NOT SHOWING SINGLE HITS. [ Show Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

    No yeast two-hybrid interactions found for this protein.

    Microscopy / Localization Data

    New Feature: Upload Your Own Microscopy Data

    No microscopy data found in the PDR for this protein.

    Protein Structure Data


    [What does the above image mean?]
    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..242] PSI-BLAST 394.9897 Putative DEAD box RNA helicase
    2 View Details [243..390] PSI-BLAST 394.9897 Putative DEAD box RNA helicase
    3 View Details [391..486] PSI-BLAST 9.154902 Nucleotide excision repair enzyme UvrB
    4 View Details [487..594] MSA 1.168988 View MSA. No confident structure predictions are available.


    Reference: Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076


    Philius Transmembrane Prediction:

    Protein predicted to be: GLOBULAR (No transmembrane regions or signal peptide)
    Confidence of classification: 0.99

    Source: Reynolds et al. (2008)

    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle