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Protein Overview: COF1

General Information:
Name(s) found: COF1 / YLL050C [SGD]
Description(s) found:
Found 44 descriptions.
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  • Cofilin, promotes actin filament depolarization in a pH-dependent manner; binds both actin monomers and filaments and severs filaments; thought to be regulated by phosphorylation at SER4; ubiquitous and essential in eukaryotes [SGD]
    • Organism: Saccharomyces cerevisiae
    Length: 143 amino acids

    Gene Ontology:
    Cellular Component: actin cortical patch [IDALink to PubMed article]
    Biological Process: actin filament severing [IDALink to PubMed article]
    actin filament depolymerization [IDALink to PubMed articleLink to PubMed article]
    actin filament organization [IMPLink to PubMed article][IPILink to PubMed article]
    Molecular Function: protein binding [IDALink to PubMed article]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MSRSGVAVAD ESLTAFNDLK LGKKYKFILF GLNDAKTEIV VKETSTDPSY DAFLEKLPEN  60
   61 DCLYAIYDFE YEINGNEGKR SKIVFFTWSP DTAPVRSKMV YASSKDALRR ALNGVSTDVQ 120
  121 GTDFSEVSYD SVLERVSRGA GSH

    Protein Complex Data

      PUBLICATION TOPOLOGY COCOMPLEXED PROTEINS
    View Details Riffle et al. (2010) (Unpublished Data) COF1 CPR1 SRV2 TWF1
    View Details (MIPS) Mewes HW, et al. (2004) ABP1 AIP1 ARC40 ARP2 BEM1 BUD6 CAP1 CAP2 COF1 CRN1 DLD2 GLK1 LAS17 OYE2 PAN1 PFY1 RVS167 SAC6 SLA1 SLA2 SRV2 TPM1 TPM2 TWF1 VRP1
    View Details Krogan NJ, et al. (2006) COF1 PUS2
    View Details Ho Y, et al. (2002) AAT2 ABP1 ACH1 ACO1 ADH2 AFR1 AHP1 AIM21 AIP1 APP1 ARC1 ARF1 ATP3 BMS1 BUD20 CAP1 CAP2 CAR2 CDC15 CDC33 CDC53 CIC1 CLU1 CMD1 CMK2 CMP2 COF1 COR1 CPR1 CPR3 CRN1 CTF4 CYR1 CYS4 DBP10 DED81 DIA2 DUG2 DUT1 EDE1 EGD1 EHD3 ENP1 ERG13 ERG6 FOL2 FPR1 FPR3 FRS2 FYV8 GCN1 GND1 GND2 GPI15 GRR1 GRX1 GUS1 HCH1 HEF3 HHF1, HHF2 HMO1 HTB1 HTB2 HYP2 ILS1 IPP1 KAP114 KGD1 KRE33 KRI1 LRO1 LSM2 LSP1 LST4 MAM33 MCM2 MCM3 MCM5 MDH1 MET6 MGM101 MRPS16 MYO2 MYO4 MYO5 NIP7 NMD3 NOP12 NTF2 OLA1 OYE2 PDC5 PDC6 PFK1 PGM2 PHO81 PIL1 POR1 PRM2 PST2 REX2 RLP24 RNR2 RRP12 RSN1 SAH1 SCP160 SEC53 SEH1 SEN15 SES1 SHE3 SKP1 SLT2 SNU13 SOD1 SPB1 SRV2 SSF1 SSF2 SSZ1 TEF4 TEM1 THS1 TIF1, TIF2 TIF6 TMA19 TMA29 TOS3 TSA2 UBA1 UBI4 URB1 UTP10 UTP20 VAS1 VMA4 VMA5 VPS13 WTM1 YAK1 YBL104C YFL006W YFR016C YGR066C YNK1
    View Details Qiu et al. (2008) ABP1 ACT1 AIP1 ARC40 ARP2 BBC1 BEM1 BNI1 BSP1 BUD6 CAP1 CAP2 COF1 CRN1 DLD2 END3 ENT1 ENT3 LAS17 OYE2 PAN1 PFY1 RVS161 RVS167 SAC6 SCD5 SCP1 SLA1 SLA2 SRV2 TPM1 TPM2 TWF1 VRP1 YSC84

    Mass Spectrometry Data

    The following runs contain data for this protein:

      BAIT COMMENTS PUBLICATION
    View Run MLP2 #34 Asynchronous SPB prep Keck JM, et al. (2011)

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    NOT SHOWING SINGLE HITS. [ Show Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

      BAIT PREY HITS PUBLICATION
    View Screen COF1 ACT1 2 Uetz P, et al. (2000)

    Microscopy / Localization Data

    New Feature: Upload Your Own Microscopy Data

    No microscopy data found in the PDR for this protein.

    Protein Structure Data


    [What does the above image mean?]
    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..143] PSI-BLAST 787.154902 Cofilin (actin depolymerizing factor, ADF)

    Functions predicted (by domain):

    # Gene Ontology predictions
    1
    Term Confidence Notes
  • actin binding
    		•  7.52071741004022 bayes_pls_golite062009
  • cytoskeletal protein binding
    		•  6.04859625643932 bayes_pls_golite062009
  • actin filament binding
    		•  5.45532510538573 bayes_pls_golite062009
  • protein binding
    		•  2.93027234013365 bayes_pls_golite062009
  • binding
    		•  2.84811181543046 bayes_pls_golite062009
  • protein kinase activity
    		•  2.04816578082974 bayes_pls_golite062009
  • phosphotransferase activity, alcohol group as acceptor
    		•  1.67227267699496 bayes_pls_golite062009
  • kinase activity
    		•  1.55883505515498 bayes_pls_golite062009
  • transferase activity, transferring phosphorus-containing groups
    		•  1.47782133980448 bayes_pls_golite062009
  • protein tyrosine kinase activity
    		•  1.4161727833926 bayes_pls_golite062009
  • phosphatidylinositol-4,5-bisphosphate binding
    		•  1.3406661967545 bayes_pls_golite062009
  • molecular transducer activity
    		•  0.693981553634544 bayes_pls_golite062009
  • signal transducer activity
    		•  0.693981553634544 bayes_pls_golite062009
  • transferase activity
    		•  0.591259446255369 bayes_pls_golite062009
  • structural constituent of cytoskeleton
    		•  0.482954032096802 bayes_pls_golite062009
  • structural molecule activity
    		•  0.391701411061931 bayes_pls_golite062009
  • enzyme regulator activity
    		•  0.270847057375333 bayes_pls_golite062009
  • actin monomer binding
    		•  0.224304003054399 bayes_pls_golite062009


    Reference: Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076


    Philius Transmembrane Prediction:

    Protein predicted to be: GLOBULAR (No transmembrane regions or signal peptide)
    Confidence of classification: 0.99

    Source: Reynolds et al. (2008)

    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle