YRC Logo
PROTEIN SEARCH:
Descriptions Names[Advanced Search]

View Structure Prediction Details

Protein: COF1
Organism: Saccharomyces cerevisiae
Length: 143 amino acids
Reference: Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076



[What does the above image mean?]


[Show Ginzu Version Information]


Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for COF1.

Description E-value Query
Range		 Subject
Range
ADF1_PETHY - Actin-depolymerizing factor 1 OS=Petunia hybrida GN=ADF1 PE=2 SV=1
 5.0E-47 [2..137] [4..139]
COF1 - Cofilin, promotes actin filament depolarization in a pH-dependent manner; binds both actin monomers ...
COFI_YEAST - Cofilin OS=Saccharomyces cerevisiae (strain ATCC 204508 / S288c) GN=COF1 PE=1 SV=1
gi|151941123 - gi|151941123|gb|EDN59501.1| actin binding and severing protein [Saccharomyces cerevisiae YJM789]
 1.0E-46 [1..143] [1..143]
ADF1_ARATH - Actin-depolymerizing factor 1 OS=Arabidopsis thaliana GN=ADF1 PE=1 SV=1
gi|195604826 - gi|195604826|gb|ACG24243.1| hypothetical protein [Zea mays]
 1.0E-46 [2..137] [4..139]
COFI_ZYGRO - Cofilin OS=Zygosaccharomyces rouxii GN=cof1 PE=2 SV=1
 2.0E-46 [1..143] [1..143]
ADF_LILLO - Actin-depolymerizing factor OS=Lilium longiflorum PE=2 SV=1
 4.0E-46 [2..136] [4..138]
COFI_PICAN - Cofilin OS=Pichia angusta GN=COF1 PE=2 SV=1
COFI_OGAPD - Cofilin OS=Ogataea parapolymorpha (strain DL-1 / ATCC 26012 / NRRL Y-7560) GN=COF1 PE=2 SV=1
 9.0E-46 [1..143] [1..143]
ADF2_ORYSJ - Actin-depolymerizing factor 2 OS=Oryza sativa subsp. japonica GN=ADF2 PE=2 SV=1
ADF2_ORYSA - Actin-depolymerizing factor 2 (ADF-2) (OsADF2) - Oryza sativa (Rice)
gi|218193843 - gi|218193843|gb|EEC76270.1| hypothetical protein OsI_13741 [Oryza sativa Indica Group]
 2.0E-45 [2..137] [10..145]

Back

Predicted Domain #1
Region A:
Residues: [1-143] 
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MSRSGVAVAD ESLTAFNDLK LGKKYKFILF GLNDAKTEIV VKETSTDPSY DAFLEKLPEN  60
   61 DCLYAIYDFE YEINGNEGKR SKIVFFTWSP DTAPVRSKMV YASSKDALRR ALNGVSTDVQ 120
  121 GTDFSEVSYD SVLERVSRGA GSH

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 787.154902
Match: 1cfyA_
Description: Cofilin (actin depolymerizing factor, ADF)
Matching Structure (courtesy of the PDB):

Predicted functions:

Term Confidence Notes
actin binding 7.52071741004022 bayes_pls_golite062009
cytoskeletal protein binding 6.04859625643932 bayes_pls_golite062009
actin filament binding 5.45532510538573 bayes_pls_golite062009
protein binding 2.93027234013365 bayes_pls_golite062009
binding 2.84811181543046 bayes_pls_golite062009
protein kinase activity 2.04816578082974 bayes_pls_golite062009
phosphotransferase activity, alcohol group as acceptor 1.67227267699496 bayes_pls_golite062009
kinase activity 1.55883505515498 bayes_pls_golite062009
transferase activity, transferring phosphorus-containing groups 1.47782133980448 bayes_pls_golite062009
protein tyrosine kinase activity 1.4161727833926 bayes_pls_golite062009
phosphatidylinositol-4,5-bisphosphate binding 1.3406661967545 bayes_pls_golite062009
molecular transducer activity 0.693981553634544 bayes_pls_golite062009
signal transducer activity 0.693981553634544 bayes_pls_golite062009
transferase activity 0.591259446255369 bayes_pls_golite062009
structural constituent of cytoskeleton 0.482954032096802 bayes_pls_golite062009
structural molecule activity 0.391701411061931 bayes_pls_golite062009
enzyme regulator activity 0.270847057375333 bayes_pls_golite062009
actin monomer binding 0.224304003054399 bayes_pls_golite062009
YRC Informatics Platform - Version 3.0
Created and Maintained by: Michael Riffle