YRC Public Data Repository - Protein Complex GO Analysis

Complex Overview

From Publication:	Gavin A.C. et al. (2002) Abstract Functional organization of the yeast proteome by systematic analysis of protein complexes. Nature. 2002 Jan 10;415(6868):141-7.
Notes:	From the published set of protein complexes.
Complex Size:	35 proteins

Complex Member Proteins

Protein	GO Cellular Component	GO Biological Process	GO Molecular Function
CMR1	nucleus cytoplasm	biological_process	molecular_function
DNA2	nucleus nuclear chromosome, telomeric region	DNA repair lagging strand elongation DNA-dependent DNA replication telomere maintenance replicative cell aging	5'-flap endonuclease activity ATP-dependent DNA helicase activity single-stranded DNA specific endodeoxyribonuclease activity
HDA1	histone deacetylase complex	loss of chromatin silencing involved in replicative cell aging regulation of transcription, DNA-dependent protein amino acid deacetylation chromatin organization	histone deacetylase activity
HDA2	nucleus histone deacetylase complex	telomere maintenance regulation of transcription, DNA-dependent histone deacetylation	histone deacetylase activity
HDA3	nucleus histone deacetylase complex	regulation of transcription, DNA-dependent histone deacetylation	histone deacetylase activity
HSC82	cytoplasm mitochondrion	telomere maintenance protein folding protein refolding proteasome assembly 'de novo' protein folding response to stress	unfolded protein binding ATPase activity, coupled
KAP95	cytoplasm nuclear pore	protein import into nucleus nuclear pore complex assembly	protein transmembrane transporter activity
LCD1	nuclear chromosome	establishment of protein localization DNA damage checkpoint telomere maintenance via telomerase	protein binding damaged DNA binding
MEC1	nucleus mitochondrion	DNA damage checkpoint DNA replication checkpoint reciprocal meiotic recombination DNA recombination telomere maintenance telomere maintenance via recombination nucleobase, nucleoside, nucleotide and nucleic acid metabolic process	protein kinase activity
MGM101	mitochondrial chromosome mitochondrion mitochondrial nucleoid	DNA repair mitochondrial genome maintenance	DNA binding
MLH1	nucleus mitochondrion	reciprocal meiotic recombination meiotic mismatch repair	ATPase activity DNA binding ATP binding
MPH1	nucleus	DNA repair	RNA helicase activity 3'-5' DNA helicase activity
MSH2	nucleus nuclear chromosome	removal of nonhomologous ends DNA recombination meiotic gene conversion meiotic mismatch repair mismatch repair chromatin silencing at silent mating-type cassette mitotic recombination	ATPase activity ATP binding double-strand/single-strand DNA junction binding DNA insertion or deletion binding loop DNA binding Y-form DNA binding four-way junction DNA binding guanine/thymine mispair binding single base insertion or deletion binding
MSH3	nucleus cytoplasm	removal of nonhomologous ends DNA recombination meiotic mismatch repair mismatch repair mitotic recombination	double-strand/single-strand DNA junction binding DNA insertion or deletion binding loop DNA binding Y-form DNA binding
MSH6	nucleus	meiotic mismatch repair mismatch repair	ATPase activity ATP binding four-way junction DNA binding guanine/thymine mispair binding single base insertion or deletion binding
OLA1	cytoplasm	biological_process	molecular_function
PGK1	cytoplasm mitochondrion	gluconeogenesis glycolysis	phosphoglycerate kinase activity
PMS1	nuclear chromosome	meiotic mismatch repair mismatch repair meiosis	ATPase activity DNA binding ATP binding
PRO2	nucleus cytoplasm	proline biosynthetic process	glutamate-5-semialdehyde dehydrogenase activity
RAD16	repairosome nucleotide-excision repair factor 4 complex	nucleotide-excision repair, DNA damage recognition	DNA-dependent ATPase activity damaged DNA binding
RAD52	nucleus nuclear chromosome	meiotic DNA recombinase assembly double-strand break repair via break-induced replication double-strand break repair via single-strand annealing telomere maintenance via recombination double-strand break repair via synthesis-dependent strand annealing DNA recombinase assembly postreplication repair	DNA strand annealing activity recombinase activity
RFA1	chromosome, telomeric region nucleus cytoplasm DNA replication factor A complex	DNA strand elongation involved in DNA replication double-strand break repair via homologous recombination DNA recombination nucleotide-excision repair telomere maintenance via recombination DNA unwinding involved in replication postreplication repair DNA replication, synthesis of RNA primer	damaged DNA binding single-stranded DNA binding
RFA2	chromosome, telomeric region DNA replication factor A complex	DNA strand elongation involved in DNA replication double-strand break repair via homologous recombination DNA recombination nucleotide-excision repair DNA unwinding involved in replication postreplication repair DNA replication, synthesis of RNA primer	DNA binding
RFA3	chromosome, telomeric region DNA replication factor A complex	DNA strand elongation involved in DNA replication double-strand break repair via homologous recombination DNA recombination nucleotide-excision repair DNA unwinding involved in replication postreplication repair DNA replication, synthesis of RNA primer	DNA binding
RIM1	mitochondrion mitochondrial nucleoid	mitochondrial genome maintenance	single-stranded DNA binding
RNH1	nucleus intracellular	cellular cell wall organization DNA replication, removal of RNA primer	ribonuclease H activity
RSC8	nucleus RSC complex	ATP-dependent chromatin remodeling double-strand break repair via nonhomologous end joining	DNA-dependent ATPase activity
RVB2	nucleus Swr1 complex Ino80 complex nuclear outer membrane chromatin remodeling complex	chromatin remodeling snoRNA metabolic process regulation of transcription from RNA polymerase II promoter	ATPase activity ATP-dependent 5'-3' DNA helicase activity
SGS1	nucleolus RecQ helicase-Topo III complex	meiotic chromosome segregation mitotic sister chromatid segregation telomere maintenance via recombination response to DNA damage stimulus replicative cell aging DNA unwinding involved in replication	ATP-dependent DNA helicase activity
SHS1	septin ring	cell morphogenesis cytokinesis	structural constituent of cytoskeleton
TIF1, TIF2	plasma membrane enriched fraction eukaryotic translation initiation factor 4F complex cytoplasm ribosome	regulation of translation translational initiation regulation of translational initiation translation	nucleotide binding nucleic acid binding translation initiation factor activity ATP binding RNA binding ATP-dependent helicase activity helicase activity ATP-dependent RNA helicase activity hydrolase activity
TOP3	nucleus RecQ helicase-Topo III complex	reciprocal meiotic recombination telomere maintenance via telomerase regulation of DNA recombination	DNA topoisomerase type I activity
VAS1	cytoplasm mitochondrion	valyl-tRNA aminoacylation	valine-tRNA ligase activity
VPS1	membrane fraction peroxisome cytoplasm mitochondrial outer membrane	protein retention in Golgi apparatus peroxisome organization vacuolar transport protein targeting to vacuole actin cytoskeleton organization	GTPase activity
YHR122W	nucleus cytoplasm	transcription	molecular_function

Cellular Component Analysis

Given the number of proteins in the complex (A), total proteins annotated with a given GO term (B), and the total number of annotated proteins (T); the p-value represents the chances of randomly having the number of proteins in the complex annotated with a specific GO term (I).

Only showing terms with a p-value less than or equal to 0.01.

GO Term	P-value	A	B	I	T
chromosome	1.2461E-8	35	274	12	6292
DNA replication factor A complex	1.5773E-7	35	3	3	6292
nucleus	4.4095E-7	35	2041	26	6292
nuclear chromosome	2.8524E-6	35	228	9	6292
intracellular organelle	4.5973E-6	35	4070	34	6292
organelle	4.6341E-6	35	4071	34	6292
chromosome, telomeric region	1.2861E-5	35	27	4	6292
membrane-bounded organelle	3.5696E-5	35	3771	32	6292
intracellular membrane-bounded organelle	3.5696E-5	35	3771	32	6292
non-membrane-bounded organelle	8.0204E-5	35	959	15	6292
intracellular non-membrane-bounded organelle	8.0204E-5	35	959	15	6292
RecQ helicase-Topo III complex	8.9875E-5	35	3	2	6292
nuclear part	1.0243E-4	35	1103	16	6292
replisome	1.2154E-4	35	18	3	6292
nuclear replisome	1.2154E-4	35	18	3	6292
nuclear replication fork	1.685E-4	35	20	3	6292
chromatin remodeling complex	1.9452E-4	35	99	5	6292
intracellular part	2.0201E-4	35	4938	35	6292
histone deacetylase complex	2.5879E-4	35	23	3	6292
intracellular	2.6256E-4	35	4975	35	6292
chromosomal part	2.6822E-4	35	237	7	6292
replication fork	1.5604E-3	35	42	3	6292
intracellular organelle part	3.5391E-3	35	2282	21	6292
organelle part	3.5391E-3	35	2282	21	6292
nuclear chromosome part	3.7013E-3	35	190	5	6292
protein-DNA complex	3.7569E-3	35	57	3	6292
cell part	4.5803E-3	35	5397	35	6292
cell	4.6403E-3	35	5399	35	6292
plasma membrane enriched fraction	5.5626E-3	35	1	1	6292
protein complex	5.8826E-3	35	1137	13	6292
nucleoid	8.9854E-3	35	26	2	6292
mitochondrial nucleoid	8.9854E-3	35	26	2	6292

Biological Process Analysis

Only showing terms with a p-value less than or equal to 0.01.

GO Term	P-value	A	B	I	T
response to DNA damage stimulus	8.0889E-16	35	236	17	6292
cellular response to stress	2.5817E-14	35	290	17	6292
DNA metabolic process	1.0289E-13	35	585	21	6292
DNA repair	5.0055E-13	35	192	14	6292
cellular response to stimulus	2.1266E-12	35	379	17	6292
response to stress	1.3626E-11	35	497	18	6292
nucleic acid metabolic process	9.6517E-11	35	1415	26	6292
DNA recombination	3.2137E-10	35	114	10	6292
meiotic mismatch repair	4.9065E-10	35	9	5	6292
nucleobase, nucleoside, nucleotide and nucleic acid metabolic process	1.0535E-9	35	1566	26	6292
cellular nitrogen compound metabolic process	2.2579E-9	35	1770	27	6292
nitrogen compound metabolic process	3.0041E-9	35	1791	27	6292
meiosis I	7.7081E-9	35	79	8	6292
DNA replication	1.4302E-8	35	123	9	6292
response to stimulus	1.7169E-8	35	766	18	6292
mitotic recombination	1.8788E-8	35	33	6	6292
meiosis	1.4229E-7	35	160	9	6292
M phase of meiotic cell cycle	1.4229E-7	35	160	9	6292
meiotic cell cycle	1.7602E-7	35	164	9	6292
DNA-dependent DNA replication	2.4684E-7	35	82	7	6292
mismatch repair	2.926E-7	35	27	5	6292
chromosome organization	5.9493E-7	35	555	14	6292
DNA strand elongation	6.0609E-7	35	31	5	6292
DNA strand elongation involved in DNA replication	6.0609E-7	35	31	5	6292
DNA unwinding involved in replication	7.7223E-7	35	14	4	6292
cellular macromolecule metabolic process	9.3716E-7	35	2285	27	6292
telomere maintenance via recombination	1.393E-6	35	16	4	6292
DNA replication, synthesis of RNA primer	1.5652E-6	35	5	3	6292
macromolecule metabolic process	1.7583E-6	35	2349	27	6292
postreplication repair	2.3236E-6	35	18	4	6292
DNA geometric change	3.6502E-6	35	20	4	6292
DNA duplex unwinding	3.6502E-6	35	20	4	6292
double-strand break repair via homologous recombination	5.4677E-6	35	22	4	6292
organelle organization	6.5615E-6	35	1127	18	6292
primary metabolic process	7.6938E-6	35	2896	29	6292
recombinational repair	1.0999E-5	35	26	4	6292
double-strand break repair	1.3465E-5	35	57	5	6292
anatomical structure homeostasis	1.815E-5	35	286	9	6292
telomere organization	1.815E-5	35	286	9	6292
telomere maintenance	1.815E-5	35	286	9	6292
M phase	2.264E-5	35	294	9	6292
cellular metabolic process	2.3505E-5	35	3033	29	6292
nucleotide-excision repair	5.1796E-5	35	38	4	6292
cellular component organization	5.3231E-5	35	1582	20	6292
metabolic process	6.0866E-5	35	3157	29	6292
cellular macromolecule biosynthetic process	6.2617E-5	35	1187	17	6292
macromolecule biosynthetic process	6.4031E-5	35	1189	17	6292
cell cycle phase	1.5518E-4	35	376	9	6292
cellular biosynthetic process	1.8088E-4	35	1567	19	6292
biosynthetic process	2.4732E-4	35	1602	19	6292
DNA conformation change	2.7512E-4	35	58	4	6292
homeostatic process	2.8806E-4	35	408	9	6292
removal of nonhomologous ends	2.9749E-4	35	5	2	6292
cell cycle	4.0596E-4	35	525	10	6292
DNA catabolic process, endonucleolytic	4.4468E-4	35	6	2	6292
protein amino acid deacetylation	5.2188E-4	35	29	3	6292
cellular process	5.3209E-4	35	4426	33	6292
regulation of biological quality	5.9811E-4	35	551	10	6292
cell cycle process	1.1038E-3	35	490	9	6292
biological regulation	1.148E-3	35	1213	15	6292
replicative cell aging	1.1643E-3	35	38	3	6292
reciprocal meiotic recombination	1.4545E-3	35	41	3	6292
gene conversion at mating-type locus	1.6022E-3	35	11	2	6292
chromatin modification	2.1688E-3	35	168	5	6292
telomere maintenance via telomerase	2.2564E-3	35	13	2	6292
RNA-dependent DNA replication	2.2564E-3	35	13	2	6292
telomere maintenance via telomere lengthening	2.2564E-3	35	13	2	6292
cell aging	2.4386E-3	35	49	3	6292
DNA damage checkpoint	2.6233E-3	35	14	2	6292
DNA damage response, signal transduction	2.6233E-3	35	14	2	6292
aging	2.7355E-3	35	51	3	6292
DNA catabolic process	3.0164E-3	35	15	2	6292
mating type switching	3.4353E-3	35	16	2	6292
lagging strand elongation	4.3495E-3	35	18	2	6292
regulation of macromolecule metabolic process	4.4754E-3	35	488	8	6292
chromatin organization	4.9093E-3	35	203	5	6292
DNA integrity checkpoint	5.3639E-3	35	20	2	6292
mating type determination	5.3639E-3	35	20	2	6292
sex determination	5.3639E-3	35	20	2	6292
DNA replication, removal of RNA primer	5.5626E-3	35	1	1	6292
pore complex assembly	5.5626E-3	35	1	1	6292
nuclear pore complex assembly	5.5626E-3	35	1	1	6292
DNA replication, Okazaki fragment processing	5.5626E-3	35	1	1	6292
valyl-tRNA aminoacylation	5.5626E-3	35	1	1	6292
meiotic gene conversion	5.5626E-3	35	1	1	6292
RNA biosynthetic process	5.7114E-3	35	508	8	6292
regulation of primary metabolic process	6.1294E-3	35	514	8	6292
regulation of nucleobase, nucleoside, nucleotide and nucleic acid metabolic process	6.9141E-3	35	415	7	6292
regulation of nitrogen compound metabolic process	7.0043E-3	35	416	7	6292
cell fate commitment	7.0682E-3	35	23	2	6292
regulation of cellular metabolic process	7.8678E-3	35	536	8	6292
regulation of metabolic process	8.8673E-3	35	547	8	6292
developmental process	9.0036E-3	35	331	6	6292
histone deacetylation	9.6706E-3	35	27	2	6292

Molecular Function Analysis

Only showing terms with a p-value less than or equal to 0.01.

GO Term	P-value	A	B	I	T
DNA binding	2.5872E-11	35	256	14	6292
nucleoside-triphosphatase activity	8.9716E-9	35	329	13	6292
ATPase activity	9.5711E-9	35	211	11	6292
pyrophosphatase activity	2.0994E-8	35	353	13	6292
hydrolase activity, acting on acid anhydrides	2.0994E-8	35	353	13	6292
hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides	2.0994E-8	35	353	13	6292
structure-specific DNA binding	1.1463E-7	35	44	6	6292
ATP binding	1.5591E-7	35	24	5	6292
adenyl ribonucleotide binding	1.9411E-7	35	25	5	6292
adenyl nucleotide binding	5.1037E-7	35	30	5	6292
purine nucleoside binding	6.0609E-7	35	31	5	6292
nucleoside binding	7.1547E-7	35	32	5	6292
nucleic acid binding	8.5986E-7	35	666	15	6292
DNA insertion or deletion binding	1.5652E-6	35	5	3	6292
mismatched DNA binding	1.5652E-6	35	5	3	6292
hydrolase activity	1.6128E-6	35	911	17	6292
ribonucleotide binding	2.5687E-6	35	41	5	6292
purine ribonucleotide binding	2.5687E-6	35	41	5	6292
double-stranded DNA binding	6.5926E-6	35	23	4	6292
purine nucleotide binding	8.5261E-6	35	52	5	6292
DNA-dependent ATPase activity	1.1277E-5	35	55	5	6292
DNA secondary structure binding	1.2949E-5	35	9	3	6292
ATPase activity, coupled	1.3983E-5	35	149	7	6292
nucleotide binding	1.5972E-5	35	59	5	6292
damaged DNA binding	2.5241E-5	35	11	3	6292
single base insertion or deletion binding	3.0063E-5	35	2	2	6292
DNA helicase activity	3.306E-5	35	34	4	6292
single-stranded DNA binding	8.4047E-5	35	16	3	6292
helicase activity	8.4171E-5	35	83	5	6292
guanine/thymine mispair binding	8.9875E-5	35	3	2	6292
double-strand/single-strand DNA junction binding	8.9875E-5	35	3	2	6292
loop DNA binding	8.9875E-5	35	3	2	6292
Y-form DNA binding	8.9875E-5	35	3	2	6292
ATP-dependent DNA helicase activity	1.2154E-4	35	18	3	6292
purine NTP-dependent helicase activity	1.3125E-4	35	48	4	6292
ATP-dependent helicase activity	1.3125E-4	35	48	4	6292
catalytic activity	1.3275E-4	35	2150	23	6292
four-way junction DNA binding	1.7912E-4	35	4	2	6292
binding	1.9329E-4	35	1294	17	6292
histone deacetylase activity	7.0035E-4	35	32	3	6292
protein deacetylase activity	7.0035E-4	35	32	3	6292
deacetylase activity	9.1366E-4	35	35	3	6292
hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides	2.298E-3	35	48	3	6292
glutamate-5-semialdehyde dehydrogenase activity	5.5626E-3	35	1	1	6292
valine-tRNA ligase activity	5.5626E-3	35	1	1	6292
endonuclease activity, active with either ribo- or deoxyribonucleic acids and producing 5'-phosphomonoesters	7.0682E-3	35	23	2	6292
hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds	9.6687E-3	35	80	3	6292

View Protein Complex Details

Complex Overview

Complex Member Proteins

Cellular Component Analysis

Biological Process Analysis

Molecular Function Analysis