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The process of assisting in the folding of a nascent peptide chain into its correct tertiary structure. The process of assisting in the covalent and noncovalent assembly of single chain polypeptides or multisubunit complexes into the correct tertiary structure. The process of assisting in the correct noncovalent folding of newly formed polypeptides or folding intermediates of polypeptides that have exited the ribosome and/or have been stabilized and transferred by other chaperone proteins. This process could involve several cycles of ATP hydrolysis. The process of assisting in the correct noncovalent assembly of the ribosome-bound nascent chains of a multidomain protein whilst other parts of the protein are still being translated. The chemical reactions and pathways involving a specific protein, rather than of proteins in general, occurring at the level of an individual cell. Includes protein modification.

View Gene Ontology (GO) Term

GO TERM SUMMARY

Name: 'de novo' protein folding
Acc: GO:0006458
Aspect: Biological Process
Desc: The process of assisting in the folding of a nascent peptide chain into its correct tertiary structure.
Synonyms:
  • nascent chain protein folding
Proteins in PDR annotated with:
   This term: 19 [Search]
   Term or descendants: 80 [Search]


[geneontology.org]
INTERACTIVE GO GRAPH

GO:0006458 - 'de novo' protein folding (interactive image map)

YRC Informatics Platform - Version 3.0
Created and Maintained by: Michael Riffle