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Any process that stops, prevents or reduces the frequency, rate or extent of initiation of DNA replication. The process whereby an activated receptor conveys information down the signaling pathway, resulting in a change in the function or state of a cell. Any process that modulates the frequency, rate or extent of initiation of DNA replication; the process by which DNA becomes competent to replicate. In eukaryotes, replication competence is established in early G1 and lost during the ensuing S phase. The process by which DNA replication is started; this involves the separation of a stretch of the DNA double helix, the recruitment of DNA polymerases and the initiation of polymerase action. Any process that modulates the frequency, rate or extent of a cellular process, any of those that are carried out at the cellular level, but are not necessarily restricted to a single cell. For example, cell communication occurs among more than one cell, but occurs at the cellular level. A signal transduction based surveillance mechanism that prevents the initiation of mitosis until DNA replication is complete, thereby ensuring that progeny inherit a full complement of the genome. The cell cycle regulatory process by which progression through the cycle can be halted until conditions are suitable for the cell to proceed to the next stage. The process whereby a signal is released and/or conveyed from one location to another. Any cell cycle checkpoint that delays or arrests cell cycle progression in response to changes in DNA structure. Any process that stops, prevents or reduces the frequency, rate or extent of DNA replication. A signal transduction based surveillance mechanism that acts during a meiotic cell cycle and prevents the initiation of mitosis until DNA replication is complete, thereby ensuring that progeny inherit a full complement of the haploid genome. A signal transduction based surveillance mechanism that acts during a mitotic cell cycle and prevents the initiation of mitosis until DNA replication is complete, thereby ensuring that progeny inherit a full complement of the genome.

View Gene Ontology (GO) Term

GO TERM SUMMARY
Name: DNA replication checkpoint
Acc: GO:0000076
Aspect: Biological Process
Desc: A signal transduction based surveillance mechanism that prevents the initiation of mitosis until DNA replication is complete, thereby ensuring that progeny inherit a full complement of the genome.
Proteins in PDR annotated with:
   This term: 55 [Search]
   Term or descendants: 56 [Search]


[geneontology.org]
INTERACTIVE GO GRAPH

GO:0000076 - DNA replication checkpoint (interactive image map)
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