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The process carried out by a cell that restores the biological activity of an unfolded or misfolded protein, using helper proteins such as chaperones. The process of assisting in the restoration of the biological activity of an unfolded or misfolded protein, which is dependent on additional protein cofactors. This process occurs over one or several cycles of nucleotide hydrolysis-dependent binding and release. The process of assisting in the covalent and noncovalent assembly of single chain polypeptides or multisubunit complexes into the correct tertiary structure. Any process that regulates the rate, frequency, or extent of protein refolding. Protein refolding is the process carried out by a cell that restores the biological activity of an unfolded or misfolded protein, using helper proteins such as chaperones. Any process that decreases the rate, frequency, or extent of protein refolding. Protein refolding is the process carried out by a cell that restores the biological activity of an unfolded or misfolded protein, using helper proteins such as chaperones. The chemical reactions and pathways involving a specific protein, rather than of proteins in general, occurring at the level of an individual cell. Includes protein modification.

View Gene Ontology (GO) Term

GO TERM SUMMARY
Name: protein refolding
Acc: GO:0042026
Aspect: Biological Process
Desc: The process carried out by a cell that restores the biological activity of an unfolded or misfolded protein, using helper proteins such as chaperones.
Synonyms:
  • heat shock protein activity
Proteins in PDR annotated with:
   This term: 37 [Search]
   Term or descendants: 38 [Search]


[geneontology.org]
INTERACTIVE GO GRAPH

GO:0042026 - protein refolding (interactive image map)
YRC Informatics Platform - Version 3.0
Created and Maintained by: Michael Riffle