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A cascade of processes induced by the detection of DNA damage within a cell. A cascade of processes initiated in response to the detection of DNA damage, and resulting in the induction of transcription. A cascade of processes induced by the cell cycle regulator phosphoprotein p53, or an equivalent protein, in response to the detection of DNA damage. A cascade of processes initiated by the detection of DNA damage and resulting in the induction of apoptosis (programmed cell death). The series of molecular events whereby information is sent from one location to another within a living organism or between living organisms. The series of molecular events whereby information is sent from one location to another within a cell. A change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus indicating the organism is under stress. The stress is usually, but not necessarily, exogenous (e.g. temperature, humidity, ionizing radiation). A signal transduction pathway, induced by DNA damage, that blocks cell cycle progression (in G1, G2 or metaphase) or slows the rate at which S phase proceeds. A change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus indicating damage to its DNA from environmental insults or errors during metabolism.

View Gene Ontology (GO) Term

GO TERM SUMMARY
Name: DNA damage response, signal transduction
Acc: GO:0042770
Aspect: Biological Process
Desc: A cascade of processes induced by the detection of DNA damage within a cell.
Synonyms:
  • response to DNA damage stimulus by intracellular signaling cascade
Proteins in PDR annotated with:
   This term: 14 [Search]
   Term or descendants: 259 [Search]


[geneontology.org]
INTERACTIVE GO GRAPH

GO:0042770 - DNA damage response, signal transduction (interactive image map)
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