Protein Overview: ADH2

General Information:
Name(s) found:	ADH2 / YMR303C [SGD]
Description(s) found: SHOW ONLY BEST	gi\|798945\|emb\|CAA89136.1\| Adh2p [Saccharomyces cerevisiae] [NCBI NR] pir\|\|DEBYA2 alcohol dehydrogenase (EC 1.1.1.1) 2 - yeast (Saccharomyces cerevisiae) [NCBI NR] gi\|6323961\|ref\|NP_014032.1\| Glucose-repressible alcohol dehydrogenase II, catalyzes the conversion of ethanol to acetaldehyde; involved in the production of certain carboxylate esters; regulated by ADR1; Adh2p [Saccharomyces cerevisiae] [NCBI NR] gi\|171021\|gb\|AAA34408.1\| alcohol dehydrogenase II [Saccharomyces cerevisiae] [NCBI NR] gi\|113380\|sp\|P00331.3\|ADH2_YEAST RecName: Full=Alcohol dehydrogenase 2; AltName: Full=YADH-2; AltName: Full=Alcohol dehydrogenase II [NCBI NR] Alcohol dehydrogenase 2 OS=Saccharomyces cerevisiae GN=ADH2 PE=1 SV=3 [Swiss-Prot] ADH2 Alcohol dehydrogenase II [mips] Glucose-repressible alcohol dehydrogenase II, catalyzes the conversion of ethanol to acetaldehyde; involved in the production of certain carboxylate esters; regulated by ADR1 [SGD] ADH2, Chr XIII from 873291-874337, reverse complement [yeast_orfs2] Chr XIII from 873291-874337, reverse complement [yeastorf3.fasta] Chr XIII from 874337-873291, reverse complement [yeastorf5.fasta] ADH2 SGDID:S0004918, Chr XIII from 874336-873290, reverse complement, Verified ORF [yeastflysequest.fasta] Adh2p [Saccharomyces cerevisiae]gi\|798945\|emb\|CAA89136.1\| Adh2p [Saccharomyces cerevisiae]gi\|171021\|gb\|AAA34408.1\| alcohol dehydrogenase II [Saccharomyces cerevisiae]gi\|113380\|sp\|P00331\|ADH2_YEAST Alcohol dehydrogenase II (YADH-2)gi\|65897\|pir\|\|DEBYA2 [nrdb_11152004_Chlamydomonas] ADH2 SGDID:S000004918, Chr XIII from 874336-873290, reverse complement, Verified ORF, "Glucose-repressible alcohol dehydrogenase II, catalyzes the conversion of ethanol to acetaldehyde; involved in the production of certain carboxylate esters; regulated b [SGD_S-cerevisiae_na_12-16-2005_con_reversed.fasta] ALCOHOL DEHYDROGENASE II gi\|65897\|pir\|\|DEBYA2 alcohol dehydrogenase (EC 1.1.1.1) II - yeast (Saccharomyces cerevisiae) gi\|171021 (J01314) alcohol dehydrogenase II [Saccharomyces cerevisiae] gi\|600021 (V01293) alcohol dehydrogenase II [Saccharomyces cerevi [rpal_3_plus_contams.fasta] Adh2p [Saccharomyces cerevisiae] [nr-271106-contam.fasta] Alcohol dehydrogenase 2 (Alcohol dehydrogenase II) (YADH-2) [nr-271106-contam.fasta] Glucose-repressible alcohol dehydrogenase II, catalyzes the conversion of ethanol to acetaldehyde; involved in the production of certain carboxylate esters; regulated by ADR1; Adh2p [Saccharomyces cerevisiae] [nr-271106-contam.fasta] alcohol dehydrogenase II [Saccharomyces cerevisiae] [nr-271106-contam.fasta] ADH2 SGDID:S000004918, Chr XIII from 874336-873290, reverse complement, Verified ORF, "Glucose-repressible alcohol dehydrogenase II, catalyzes the conversion of ethanol to acetaldehyde; involved in the production of certain carboxylate esters; regulated by ADR1" [yeast-bovrabprots.fasta] [chemostatdb.fasta] Alcohol dehydrogenase 2 OS=Saccharomyces cerevisiae (strain ATCC 204508 / S288c) GN=ADH2 PE=1 SV=3 [UniProt_S_cerevisiae_20120516_05-16-2012_reversed.fasta] ADH2 SGDID:S000004918, Chr XIII from 874337-873291, Genome Release 64-1-1, reverse complement, Verified ORF, "Glucose-repressible alcohol dehydrogenase II, catalyzes the conversion of ethanol to acetaldehyde; involved in the production of certain carboxylate esters; regulated by ADR1" [yeast-030211-contam.fasta] ADH2 SGDID:S000004918, Chr XIII from 874337-873291, Genome Release 64-2-1, reverse complement, Verified ORF, "Glucose-repressible alcohol dehydrogenase II; catalyzes the conversion of ethanol to acetaldehyde; involved in the production of certain carboxylate esters; regulated by ADR1" [20141208_orf_trans.fasta] YMR303C SGDID:S000004918, Chr XIII from 874337-873291, Genome Release 64-1-1, reverse complement, Verified ORF, "Glucose-repressible alcohol dehydrogenase II, catalyzes the conversion of ethanol to acetaldehyde; involved in the production of certain carboxylate esters; regulated by ADR1" [2016-01-SGD_Yeast_Contam_Riffle_20140507-Ska-Hec-110-tubulin.fasta]
Organism:	Saccharomyces cerevisiae
Length:	348 amino acids
Gene Ontology:
Cellular Component:	cytoplasm [IDA ]
Biological Process:	fermentation [IMP][TAS] ethanol metabolic process [IDA][TAS] NADH oxidation [IDA]
Molecular Function:	alcohol dehydrogenase (NAD) activity [IDA]

Sequence:

Sequence:
[PDR BLAST]
[ProtParam]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MSIPETQKAI IFYESNGKLE HKDIPVPKPK PNELLINVKY SGVCHTDLHA WHGDWPLPTK  60
   61 LPLVGGHEGA GVVVGMGENV KGWKIGDYAG IKWLNGSCMA CEYCELGNES NCPHADLSGY 120
  121 THDGSFQEYA TADAVQAAHI PQGTDLAEVA PILCAGITVY KALKSANLRA GHWAAISGAA 180
  181 GGLGSLAVQY AKAMGYRVLG IDGGPGKEEL FTSLGGEVFI DFTKEKDIVS AVVKATNGGA 240
  241 HGIINVSVSE AAIEASTRYC RANGTVVLVG LPAGAKCSSD VFNHVVKSIS IVGSYVGNRA 300
  301 DTREALDFFA RGLVKSPIKV VGLSSLPEIY EKMEKGQIAG RYVVDTSK

Protein Complex Data

	PUBLICATION	TOPOLOGY	COCOMPLEXED PROTEINS
View Details	Riffle et al. (2010) (Unpublished Data)		ADH1 ADH2 ADH3 EFT2, EFT1 HXK1 HYP2 TDH1
View Details	Ho Y, et al. (2002)		AAC3 ACC1 ACH1 ADE5,7 ADH2 ADH5 ADR1 AHA1 AHP1 AIM21 AIR2 BUD20 CAR2 CDC16 CDC33 CDC42 CDC53 CIC1 CKA1 COF1 COP1 CPR1 CPR6 DED1 DSS1 EHD3 ERB1 FKH2 FOL2 FPR3 GCD11 GFA1 GND1 GPI15 GUF1 GUS1 HEM15 HHF1, HHF2 HMO1 HRT3 HSP104 HTB1 HTB2 HYM1 HYP2 IDH1 IDH2 ILV5 INO80 ISA2 KIC1 KRE33 KRI1 LCD1 LOC1 LSM2 MAM33 MDH1 MES1 MET18 MGM101 MKT1 MMS4 MPC54 MRPS16 MRPS35 MUS81 NGL2 NHP2 NOP12 NOP2 NPL3 OYE2 OYE3 POR1 PST2 PWP1 PYC1 PYC2 QCR2 QNS1 RAD53 RCN2 RET1 RFC1 RFC2 RFC4 RLP24 RNQ1 RPA135 RPA190 RPA49 RPB5 RPC10 RPC19 RPC25 RPC34 RPC40 RPC82 RPF2 RPN3 RPO26 RPO31 RPT3 RVS167 SEC23 SEC27 SES1 SIN3 SKP1 SLD2 SLP1 SOD1 SRP1 TAF14 TBS1 TEF4 TFP1 TRL1 TSA2 UBI4 UTP20 UTP22 YBL108W YCK1 YFL006W YFL042C YHB1 YHR020W YHR112C YRA1
View Details	Qiu et al. (2008)		ADH1 ADH2

Mass Spectrometry Data

The following runs contain data for this protein:

	BAIT	COMMENTS	PUBLICATION
View Run	TIM50	No Comments	Hazbun TR, et al. (2003)
View Run	RPA135	his-HA tag on RPA135	Schneider, DA, et al. (2006)
View Run	RPA135	his-HA tag on RPA135	Schneider, DA, et al. (2006)
View Run	DAD1	Dam1-765 complex purified from yeast with Dad1-TAP	Shimogawa MM, et al. (2006)
View Run	RLF2	cac1: TAP-tagged	Green EM, et al (2005)
View Run	MLP2	#24 Asynchronous Prep3-TiO2 Phosphopeptide enrichment	Keck JM, et al. (2011)
View Run	MLP2	#29 Asynchronous Prep5-TiO2 Flowthrough	Keck JM, et al. (2011)

Yeast Two-Hybrid Data

The following interactions contain this protein:

NOT SHOWING SINGLE HITS. [ Show Single Hits ]

[View our yeast two-hybrid interpretation guidelines.]

	BAIT	PREY	HITS	PUBLICATION
View Screen	ADH2	YFL042C	2	Uetz P, et al. (2000)

Microscopy / Localization Data

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	PROTEIN(S)	PUBLICATION
View Data	ADH2	Huh WK, et al. (2003)

Protein Structure Data

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[View Top Sequence Alignments] [Show Ginzu Version Information]

Domains predicted:

#		Region(s)	Method	Confidence	Match Description
1	View Details	[1..153] [315..348]	PSI-BLAST	284.156545	Ketose reductase (sorbitol dehydrogenase)
2	View Details	[154..314]	PSI-BLAST	284.156545	Ketose reductase (sorbitol dehydrogenase)

Reference: Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076

Philius Transmembrane Prediction:

Protein predicted to be:	GLOBULAR (No transmembrane regions or signal peptide)
Confidence of classification:	0.80

Source: Reynolds et al. (2008)

TMHMM	2.0c	PSIPRED	v2.61
SignalP	3.0	COILS	1999
DISOPRED	v0.1	NCBI nr	06/2007
PSI-BLAST	2.2.18	FFAS	ffas03
PDB	06/2007	Pfam	22
HMMER	2.3.2