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Protein Overview: HYM1

General Information:
Name(s) found: HYM1 / YKL189W [SGD]
Description(s) found:
Found 25 descriptions.
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  • Component of the RAM signaling network that is involved in regulation of Ace2p activity and cellular morphogenesis, interacts with Kic1p and Sog2p, localizes to sites of polarized growth during budding and during the mating response [SGD]
    • Organism: Saccharomyces cerevisiae
    Length: 399 amino acids

    Gene Ontology:
    Cellular Component: incipient cellular bud site [IDALink to PubMed article]
    cellular bud [IDALink to PubMed article]
    mating projection tip [IDALink to PubMed article]
    intracellular [IDALink to PubMed article]
    Biological Process: regulation of cell shape [IGILink to PubMed article]
    cytokinesis, completion of separation [IMPLink to PubMed article]
    cell morphogenesis during vegetative growth [IGILink to PubMed article]
    regulation of transcription [IMPLink to PubMed article]
    Molecular Function: molecular_function [ND]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MFKKYKNQDL DMAFWWKKNP KTPSDYARLI IEQLNKFSSP SLTQDNKRKV QEECTKYLIG  60
   61 TKHFIVGDTD PHPTPEAIDE LYTAMHRADV FYELLLHFVD LEFEARRECM LIFSICLGYS 120
  121 KDNKFVTVDY LVSQPKTISL MLRTAEVALQ QKGCQDIFLT VGNMIIECIK YEQLCRIILK 180
  181 DPQLWKFFEF AKLGNFEIST ESLQILSAAF TAHPKLVSKE FFSNEINIIR FIKCINKLMA 240
  241 HGSYVTKRQS TKLLASLIVI RSNNALMNIY INSPENLKLI MTLMTDKSKN LQLEAFNVFK 300
  301 VMVANPRKSK PVFDILVKNR DKLLTYFKTF GLDSQDSTFL DEREFIVQEI DSLPRIISST 360
  361 TEVSNNNASS SNVASITSPS SVMNNQSSIL THSTSPDSR

    Protein Complex Data

      PUBLICATION TOPOLOGY COCOMPLEXED PROTEINS
    View Details Ho Y, et al. (2002) ADH2 FET3 HYM1 KIC1 PEX19 UFD4
    View Details Qiu et al. (2008) HYM1 SOG2

    Mass Spectrometry Data

    The following runs contain data for this protein:

      BAIT COMMENTS PUBLICATION
    View Run MLP2 #31 Asynchronous Prep (Protease cleavage) Keck JM, et al. (2011)

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    NOT SHOWING SINGLE HITS. [ Show Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

    No yeast two-hybrid interactions found for this protein.

    Microscopy / Localization Data

    New Feature: Upload Your Own Microscopy Data

      PROTEIN(S) PUBLICATION
    View Data HYM1 Huh WK, et al. (2003)

    Protein Structure Data


    [What does the above image mean?]
    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..122] ORFEUS 7.94 Karyopherin alpha
    2 View Details [123..244] ORFEUS 7.94 Karyopherin alpha
    3 View Details [245..399] ORFEUS 7.94 Karyopherin alpha

    Functions predicted (by domain):

    # Gene Ontology predictions
    1
    Term Confidence Notes
  • actin binding
    		•  3.34487439883854 bayes_pls_golite062009
  • binding
    		•  3.0667965351474 bayes_pls_golite062009
  • protein transporter activity
    		•  3.05338750264476 bayes_pls_golite062009
  • cytoskeletal protein binding
    		•  2.61566088685247 bayes_pls_golite062009
  • nucleic acid binding
    		•  2.44247330635325 bayes_pls_golite062009
  • transcription regulator activity
    		•  2.16673352512615 bayes_pls_golite062009
  • DNA binding
    		•  1.95242774903625 bayes_pls_golite062009
  • protein binding
    		•  1.73688475473996 bayes_pls_golite062009
  • transporter activity
    		•  1.55621630624352 bayes_pls_golite062009
  • substrate-specific transporter activity
    		•  1.33334123659384 bayes_pls_golite062009
  • transcription factor activity
    		•  1.20660383756339 bayes_pls_golite062009
  • protein transmembrane transporter activity
    		•  1.15447282085461 bayes_pls_golite062009
  • kinase activity
    		•  0.91225570265123 bayes_pls_golite062009
  • phosphotransferase activity, alcohol group as acceptor
    		•  0.899445296506937 bayes_pls_golite062009
  • transferase activity, transferring phosphorus-containing groups
    		•  0.807989794741213 bayes_pls_golite062009
  • protein kinase activity
    		•  0.619400541646196 bayes_pls_golite062009
  • nuclear localization sequence binding
    		•  0.611068932532731 bayes_pls_golite062009
  • transferase activity
    		•  0.55535086327389 bayes_pls_golite062009
  • RNA binding
    		•  0.40024158562931 bayes_pls_golite062009
  • transmembrane transporter activity
    		•  0.350388174853674 bayes_pls_golite062009
  • protein phosphatase binding
    		•  0.29069227304597 bayes_pls_golite062009
  • structural molecule activity
    		•  0.279926218252647 bayes_pls_golite062009
  • signal sequence binding
    		•  0.27824906981293 bayes_pls_golite062009
  • transcription activator activity
    		•  0.160275383613705 bayes_pls_golite062009
  • substrate-specific transmembrane transporter activity
    		•  0.141331164449492 bayes_pls_golite062009
  • phosphatase binding
    		•  0.11039819726831 bayes_pls_golite062009
  • protein serine/threonine kinase activity
    		•  0.100741172685176 bayes_pls_golite062009
  • transcription factor binding
    		•  0.0221966060394205 bayes_pls_golite062009
    2 No functions predicted.
    3 No functions predicted.


    Reference: Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076


    Philius Transmembrane Prediction:

    Protein predicted to be: GLOBULAR (No transmembrane regions or signal peptide)
    Confidence of classification: 0.99

    Source: Reynolds et al. (2008)

    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle