YRC Public Data Repository - Protein Structure Prediction

Protein:	HYM1
Organism:	Saccharomyces cerevisiae
Length:	399 amino acids
Reference:	Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076

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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for HYM1.

Description	E-value	Query Range	Subject Range
HYM1 - Component of the RAM signaling network that is involved in regulation of Ace2p activity and cellular... HYM1_YEAST - Protein HYM1 OS=Saccharomyces cerevisiae (strain ATCC 204508 / S288c) GN=HYM1 PE=1 SV=1	0.0	[1..399]	[1..399]
gi\|26345724, gi\|... - gi\|26345724\|dbj\|BAC36513.1\| unnamed protein product [Mus musculus], gi\|16359342\|gb\|AAH16128.1\| Cab39...	0.0	[12..355]	[1..331]
gi\|114649660, gi... - gi\|55640217\|ref\|XP_509779.1\| PREDICTED: calcium binding protein 39-like isoform 6 [Pan troglodytes],... CAB39L - calcium binding protein 39-like	0.0	[12..355]	[1..331]
gi\|7507776 - gi\|7507776\|pir\|\|T16867 probable cytochrome P450 T13C5.1 [similarity] - Caenorhabditis elegans	0.0	[12..381]	[1..375]
MO25M_ARATH - Putative MO25-like protein At4g17270 OS=Arabidopsis thaliana GN=At4g17270 PE=2 SV=1	0.0	[12..354]	[1..338]

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Predicted Domain #1

Region A:
Residues: [1-122]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MFKKYKNQDL DMAFWWKKNP KTPSDYARLI IEQLNKFSSP SLTQDNKRKV QEECTKYLIG  60
   61 TKHFIVGDTD PHPTPEAIDE LYTAMHRADV FYELLLHFVD LEFEARRECM LIFSICLGYS 120
  121 KD

[Run NCBI BLAST on this sequence.]

Detection Method:	ORFEUS
Confidence:	7.94
Match:	1ee5A
Description:	Karyopherin alpha
Matching Structure (courtesy of the PDB):

Predicted functions:

Term	Confidence	Notes
actin binding	3.34487439883854	bayes_pls_golite062009
binding	3.0667965351474	bayes_pls_golite062009
protein transporter activity	3.05338750264476	bayes_pls_golite062009
cytoskeletal protein binding	2.61566088685247	bayes_pls_golite062009
nucleic acid binding	2.44247330635325	bayes_pls_golite062009
transcription regulator activity	2.16673352512615	bayes_pls_golite062009
DNA binding	1.95242774903625	bayes_pls_golite062009
protein binding	1.73688475473996	bayes_pls_golite062009
transporter activity	1.55621630624352	bayes_pls_golite062009
substrate-specific transporter activity	1.33334123659384	bayes_pls_golite062009
transcription factor activity	1.20660383756339	bayes_pls_golite062009
protein transmembrane transporter activity	1.15447282085461	bayes_pls_golite062009
kinase activity	0.91225570265123	bayes_pls_golite062009
phosphotransferase activity, alcohol group as acceptor	0.899445296506937	bayes_pls_golite062009
transferase activity, transferring phosphorus-containing groups	0.807989794741213	bayes_pls_golite062009
protein kinase activity	0.619400541646196	bayes_pls_golite062009
nuclear localization sequence binding	0.611068932532731	bayes_pls_golite062009
transferase activity	0.55535086327389	bayes_pls_golite062009
RNA binding	0.40024158562931	bayes_pls_golite062009
transmembrane transporter activity	0.350388174853674	bayes_pls_golite062009
protein phosphatase binding	0.29069227304597	bayes_pls_golite062009
structural molecule activity	0.279926218252647	bayes_pls_golite062009
signal sequence binding	0.27824906981293	bayes_pls_golite062009
transcription activator activity	0.160275383613705	bayes_pls_golite062009
substrate-specific transmembrane transporter activity	0.141331164449492	bayes_pls_golite062009
phosphatase binding	0.11039819726831	bayes_pls_golite062009
protein serine/threonine kinase activity	0.100741172685176	bayes_pls_golite062009
transcription factor binding	0.0221966060394205	bayes_pls_golite062009

Predicted Domain #2

Region A:
Residues: [123-244]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 NKFVTVDYLV SQPKTISLML RTAEVALQQK GCQDIFLTVG NMIIECIKYE QLCRIILKDP  60
   61 QLWKFFEFAK LGNFEISTES LQILSAAFTA HPKLVSKEFF SNEINIIRFI KCINKLMAHG 120
  121 SY

[Run NCBI BLAST on this sequence.]

Detection Method:	ORFEUS
Confidence:	7.94
Match:	1ee5A
Description:	Karyopherin alpha
Matching Structure (courtesy of the PDB):

Predicted Domain #3

Region A:
Residues: [245-399]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 VTKRQSTKLL ASLIVIRSNN ALMNIYINSP ENLKLIMTLM TDKSKNLQLE AFNVFKVMVA  60
   61 NPRKSKPVFD ILVKNRDKLL TYFKTFGLDS QDSTFLDERE FIVQEIDSLP RIISSTTEVS 120
  121 NNNASSSNVA SITSPSSVMN NQSSILTHST SPDSR

[Run NCBI BLAST on this sequence.]

Detection Method:	ORFEUS
Confidence:	7.94
Match:	1ee5A
Description:	Karyopherin alpha
Matching Structure (courtesy of the PDB):

TMHMM	2.0c	PSIPRED	v2.61
SignalP	3.0	COILS	1999
DISOPRED	v0.1	NCBI nr	06/2007
PSI-BLAST	2.2.18	FFAS	ffas03
PDB	06/2007	Pfam	22
HMMER	2.3.2

View Structure Prediction Details

Top Sequence Alignment Hits

Predicted functions: