Protein Overview: HYM1

General Information:
Name(s) found:	HYM1 / YKL189W [SGD]
Description(s) found: Found 25 descriptions. SHOW ALL	Component of the RAM signaling network that is involved in regulation of Ace2p activity and cellular morphogenesis, interacts with Kic1p and Sog2p, localizes to sites of polarized growth during budding and during the mating response [SGD]
Organism:	Saccharomyces cerevisiae
Length:	399 amino acids
Gene Ontology:
Cellular Component:	incipient cellular bud site [IDA] cellular bud [IDA] mating projection tip [IDA] intracellular [IDA]
Biological Process:	regulation of cell shape [IGI] cytokinesis, completion of separation [IMP] cell morphogenesis during vegetative growth [IGI] regulation of transcription [IMP]
Molecular Function:	molecular_function [ND]

Sequence:

Sequence:
[PDR BLAST]
[ProtParam]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MFKKYKNQDL DMAFWWKKNP KTPSDYARLI IEQLNKFSSP SLTQDNKRKV QEECTKYLIG  60
   61 TKHFIVGDTD PHPTPEAIDE LYTAMHRADV FYELLLHFVD LEFEARRECM LIFSICLGYS 120
  121 KDNKFVTVDY LVSQPKTISL MLRTAEVALQ QKGCQDIFLT VGNMIIECIK YEQLCRIILK 180
  181 DPQLWKFFEF AKLGNFEIST ESLQILSAAF TAHPKLVSKE FFSNEINIIR FIKCINKLMA 240
  241 HGSYVTKRQS TKLLASLIVI RSNNALMNIY INSPENLKLI MTLMTDKSKN LQLEAFNVFK 300
  301 VMVANPRKSK PVFDILVKNR DKLLTYFKTF GLDSQDSTFL DEREFIVQEI DSLPRIISST 360
  361 TEVSNNNASS SNVASITSPS SVMNNQSSIL THSTSPDSR

Protein Complex Data

	PUBLICATION	TOPOLOGY	COCOMPLEXED PROTEINS
View Details	Ho Y, et al. (2002)		ADH2 FET3 HYM1 KIC1 PEX19 UFD4
View Details	Qiu et al. (2008)		HYM1 SOG2

Mass Spectrometry Data

The following runs contain data for this protein:

	BAIT	COMMENTS	PUBLICATION
View Run	MLP2	#31 Asynchronous Prep (Protease cleavage)	Keck JM, et al. (2011)

Yeast Two-Hybrid Data

The following interactions contain this protein:

SHOWING SINGLE HITS. [ Hide Single Hits ]

[View our yeast two-hybrid interpretation guidelines.]

	BAIT	PREY	HITS	PUBLICATION
View Screen	YDR131C	HYM1	1	Unpublished Fields Lab Data
View Screen	LIA1	HYM1	1	Unpublished Fields Lab Data
View Screen	IML1	HYM1	1	Unpublished Fields Lab Data
View Screen	UBC12	HYM1	1	Unpublished Fields Lab Data
View Screen	COG4	HYM1	1	Unpublished Fields Lab Data

Microscopy / Localization Data

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	PROTEIN(S)	PUBLICATION
View Data	HYM1	Huh WK, et al. (2003)

Protein Structure Data

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[View Top Sequence Alignments] [Show Ginzu Version Information]

Domains predicted:

#		Region(s)	Method	Confidence	Match Description
1	View Details	[1..122]	ORFEUS	7.94	Karyopherin alpha
2	View Details	[123..244]	ORFEUS	7.94	Karyopherin alpha
3	View Details	[245..399]	ORFEUS	7.94	Karyopherin alpha

Functions predicted (by domain):

Gene Ontology predictions

Term	Confidence	Notes
actin binding	3.34487439883854	bayes_pls_golite062009
binding	3.0667965351474	bayes_pls_golite062009
protein transporter activity	3.05338750264476	bayes_pls_golite062009
cytoskeletal protein binding	2.61566088685247	bayes_pls_golite062009
nucleic acid binding	2.44247330635325	bayes_pls_golite062009
transcription regulator activity	2.16673352512615	bayes_pls_golite062009
DNA binding	1.95242774903625	bayes_pls_golite062009
protein binding	1.73688475473996	bayes_pls_golite062009
transporter activity	1.55621630624352	bayes_pls_golite062009
substrate-specific transporter activity	1.33334123659384	bayes_pls_golite062009
transcription factor activity	1.20660383756339	bayes_pls_golite062009
protein transmembrane transporter activity	1.15447282085461	bayes_pls_golite062009
kinase activity	0.91225570265123	bayes_pls_golite062009
phosphotransferase activity, alcohol group as acceptor	0.899445296506937	bayes_pls_golite062009
transferase activity, transferring phosphorus-containing groups	0.807989794741213	bayes_pls_golite062009
protein kinase activity	0.619400541646196	bayes_pls_golite062009
nuclear localization sequence binding	0.611068932532731	bayes_pls_golite062009
transferase activity	0.55535086327389	bayes_pls_golite062009
RNA binding	0.40024158562931	bayes_pls_golite062009
transmembrane transporter activity	0.350388174853674	bayes_pls_golite062009
protein phosphatase binding	0.29069227304597	bayes_pls_golite062009
structural molecule activity	0.279926218252647	bayes_pls_golite062009
signal sequence binding	0.27824906981293	bayes_pls_golite062009
transcription activator activity	0.160275383613705	bayes_pls_golite062009
substrate-specific transmembrane transporter activity	0.141331164449492	bayes_pls_golite062009
phosphatase binding	0.11039819726831	bayes_pls_golite062009
protein serine/threonine kinase activity	0.100741172685176	bayes_pls_golite062009
transcription factor binding	0.0221966060394205	bayes_pls_golite062009

No functions predicted.

Reference: Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076

Philius Transmembrane Prediction:

Protein predicted to be:	GLOBULAR (No transmembrane regions or signal peptide)
Confidence of classification:	0.99

Source: Reynolds et al. (2008)

TMHMM	2.0c	PSIPRED	v2.61
SignalP	3.0	COILS	1999
DISOPRED	v0.1	NCBI nr	06/2007
PSI-BLAST	2.2.18	FFAS	ffas03
PDB	06/2007	Pfam	22
HMMER	2.3.2