Protein Overview: IMD3

General Information:
Name(s) found:	IMD3 / YLR432W [SGD]
Description(s) found: Found 24 descriptions. SHOW ALL	Inosine monophosphate dehydrogenase, catalyzes the first step of GMP biosynthesis, member of a four-gene family in S. cerevisiae, constitutively expressed [SGD]
Organism:	Saccharomyces cerevisiae
Length:	523 amino acids
Gene Ontology:
Cellular Component:	cytoplasm [IDA ]
Biological Process:	GTP biosynthetic process [TAS]
Molecular Function:	IMP dehydrogenase activity [TAS]

Sequence:

Sequence:
[PDR BLAST]
[ProtParam]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MAAVRDYKTA LEFAKSLPRL DGLSVQELMD SKTRGGLTYN DFLVLPGLVD FPSSEVSLQT  60
   61 KLTRNITLNT PFVSSPMDTV TESEMAIFMA LLGGIGFIHH NCTPEDQADM VRRVKNYENG 120
  121 FINNPIVISP TTTVGEAKSM KERFGFSGFP VTEDGKRNGK LMGIVTSRDI QFVEDNSLLV 180
  181 QDVMTKNPVT GAQGITLSEG NEILKKIKKG KLLIVDDNGN LVSMLSRTDL MKNQNYPLAS 240
  241 KSATTKQLLC GAAIGTIDAD KERLRLLVEA GLDVVILDSS QGNSIFQLNM IKWIKETFPD 300
  301 LEIIAGNVAT REQAANLIAA GADGLRIGMG SGSICITQEV MACGRPQGTA VYNVCEFANQ 360
  361 FGIPCMADGG VQNIGHITKA LALGSSTVMM GGMLAGTTES PGEYFYQDGK RLKAYRGMGS 420
  421 IDAMQKTGTK GNASTSRYFS ESDSVLVAQG VSGAVVDKGS IKKFIPYLYN GLQHSCQDIG 480
  481 YKSLTLLKEN VQSGKVRFEF RTASAQLEGG VHNLHSYEKR LHN

Protein Complex Data

	PUBLICATION	TOPOLOGY	COCOMPLEXED PROTEINS
View Details	Riffle et al. (2010) (Unpublished Data)		FUN12 IMD1 IMD2 IMD3 IMD4 KEM1 KRE33 NOP12 PUF6 RPF2 RPL10 RPL11B RPL15A RPL18A, RPL18B RPL20B RPL4B RPL5 RPL9B RPP0 RPS1B RPS2 RPS3 RPS4B, RPS4A RPS6A, RPS6B RRP5 STM1 UTP22 YAR075W
View Details	Krogan NJ, et al. (2006)		COX18 IMD1 IMD2 IMD3 IMD4 PDE2 YAR075W
View Details	Ho Y, et al. (2002)		ACS2 ADE3 ADE6 ADO1 AI1 AIM46 AIR1 AIR2 ALA1 APE2 ARA1 ARE1 BAT1 CBF5 CBP2 CCM1 CDC10 CDC33 CIC1 CKA1 CKA2 CKB1 CLU1 CYS3 DBP7 DED81 DPS1 DRS1 EBP2 ELA1 ENP2 ERG10 ERG20 ESF1 ESF2 FET4 FUN12 GBP2 GCY1 GPH1 GRS1 HAS1 HHO1 HMO1 HOM2 HPR1 HTB1 HTB2 HYP2 ILS1 IMD1 IMD2 IMD3 IMD4 ISA1 KRE33 KRI1 KRS1 LAA1 LHP1 LSP1 MAG1 MAG2 MDH3 MFT1 MGM101 MPH1 MSC3 MSH2 MSS116 MTR4 NAP1 NOC2 NOG1 NOP1 NOP12 NOP13 NOP4 NOP53 NOP56 NOP6 NOP7 NPL3 OLA1 OYE2 PAB1 PAP2 PDC6 PET127 PFK2 PGM2 PMA1 PMI40 POL5 PRP43 PRP6 PSE1 PUF6 PWP1 RET1 RLI1 RPC82 RPF2 RRP12 RRP5 SAC6 SCP160 SOD1 SSZ1 SUB2 TEX1 THO2 THP2 THR4 TIF4631 TIF4632 TIS11 TRA1 TRR1 TSR1 UBA1 URB1 URB2 UTP10 UTP20 UTP22 YCR087W YDL124W YDR102C YER077C YPP1 YRA1 YTM1
View Details	Qiu et al. (2008)		IMD3 RPL4B

Mass Spectrometry Data

The following runs contain data for this protein:

	BAIT	COMMENTS	PUBLICATION
View Run	PSF2	No Comments	Hazbun TR, et al. (2003)
View Run	HSL7	No Comments	McCusker D, et al (2007)
View Run	SEC10	No Comments	De Craene, J., et al. (2006)
View Run	RPA135	his-HA tag on RPA135	Schneider, DA, et al. (2006)
View Run	RPA135	his-HA tag on RPA135	Schneider, DA, et al. (2006)
View Run	MIH1	control 1	McCusker D, et al (2007)
View Run	MIH1	control 2	McCusker D, et al (2007)
View Run	MIH1	experimental1 - mih1-1	McCusker D, et al (2007)
View Run	MIH1	experimental2 - mih1-2	McCusker D, et al (2007)
View Run	ZDS1	Sample 2- cpn2 from june 2005	McCusker D, et al (2007)
View Run	BOI1	Sample boi 1 with ha tag from october 2005	McCusker D, et al (2007)
View Run	BOI1	Sample boi1 with gst from october 2005	McCusker D, et al (2007)
View Run	BOI1	Sample bob1 (2nd set) from october 2005	McCusker D, et al (2007)
View Run	BOI2	Boi 2 gst control	McCusker D, et al (2007)
View Run	None Entered	#17 Mitotic Prep3-TiO2 Phosphopeptide enrichment	Keck JM, et al. (2011)

Yeast Two-Hybrid Data

The following interactions contain this protein:

SHOWING SINGLE HITS. [ Hide Single Hits ]

[View our yeast two-hybrid interpretation guidelines.]

	BAIT	PREY	HITS	PUBLICATION
View Screen	PSE1	IMD3	1	Unpublished Fields Lab Data

Microscopy / Localization Data

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	PROTEIN(S)	PUBLICATION
View Data	IMD3	Huh WK, et al. (2003)

Protein Structure Data

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[View Top Sequence Alignments] [Show Ginzu Version Information]

Domains predicted:

#		Region(s)	Method	Confidence	Match Description
1	View Details	[1..523]	PSI-BLAST	10149.0	Inosine monophosphate dehydrogenase (IMPDH); Type II inosine monophosphate dehydrogenase

Functions predicted (by domain):

Gene Ontology predictions

Term	Confidence	Notes
IMP dehydrogenase activity	2.02048863053452	bayes_pls_golite062009
binding	0.964202692685807	bayes_pls_golite062009
transporter activity	0.961062314616209	bayes_pls_golite062009
transmembrane transporter activity	0.807029018941177	bayes_pls_golite062009
substrate-specific transporter activity	0.640881170978843	bayes_pls_golite062009
substrate-specific transmembrane transporter activity	0.525366315833255	bayes_pls_golite062009
ion transmembrane transporter activity	0.440262824681055	bayes_pls_golite062009
protein binding	0.22179604283012	bayes_pls_golite062009
catalytic activity	0.181756622780318	bayes_pls_golite062009
di-, tri-valent inorganic cation transmembrane transporter activity	0.0973526732376297	bayes_pls_golite062009

Reference: Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076

Philius Transmembrane Prediction:

Protein predicted to be:	GLOBULAR (No transmembrane regions or signal peptide)
Confidence of classification:	0.92

Source: Reynolds et al. (2008)

TMHMM	2.0c	PSIPRED	v2.61
SignalP	3.0	COILS	1999
DISOPRED	v0.1	NCBI nr	06/2007
PSI-BLAST	2.2.18	FFAS	ffas03
PDB	06/2007	Pfam	22
HMMER	2.3.2