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Protein Overview: COX18

General Information:
Name(s) found: COX18 / YGR062C [SGD]
Description(s) found:
Found 29 descriptions.
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  • Mitochondrial integral inner membrane protein required for membrane insertion of C-terminus of Cox2p; interacts genetically and physically with Mss2p and Pnt1p; similar to S. cerevisiae Oxa1, N. crassa Oxa2p, and E. coli YidC [SGD]
    • Organism: Saccharomyces cerevisiae
    Length: 316 amino acids

    Gene Ontology:
    Cellular Component: integral to membrane [IDALink to PubMed article]
    mitochondrial inner membrane [IDALink to PubMed article]
    Biological Process: respiratory chain complex IV assembly [IMPLink to PubMed article]
    Molecular Function: protein transporter activity [IMPLink to PubMed article]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MLKRLANRQN GFASFSCSSV GLRYGRTNPS TKRSFSLFQS VADTFLTVHE ASHIPWIVLV  60
   61 PLTTMTLRTL VTLPFSIWQR RRILKQQELR KLVQPITPII KLRLAAVTNK KSRNAARISS 120
  121 NGSFMPLQLQ NAGVLTPEQI TLLAVKETRK RQKKLFKKYN VPLWKNALLP MVQIPLWVTV 180
  181 SMGIRTLTET QLIESFYPSW FSALGFSSFD LSSPLVAMPL LAPILVGTLA VLNVELNGRL 240
  241 MFSSSLSSQG IKTISRNSTR VQEAMTSILN VSRLGCVVML AMSSQAPFLL SLYWISSQLF 300
  301 SLVQNIILNW IYPYQR

    Protein Complex Data

      PUBLICATION TOPOLOGY COCOMPLEXED PROTEINS
    View Details Krogan NJ, et al. (2006) COX18 IMD1 IMD2 IMD3 IMD4 PDE2 YAR075W
    View Details Qiu et al. (2008) COX18 MSS2

    Mass Spectrometry Data

    The following runs contain data for this protein:

      BAIT COMMENTS PUBLICATION
    View Run MLP2 #29 Asynchronous Prep5-TiO2 Flowthrough Keck JM, et al. (2011)
    View Run MLP2 #12 Mitotic Prep1-TiO2 Flowthrough Keck JM, et al. (2011)

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    NOT SHOWING SINGLE HITS. [ Show Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

    No yeast two-hybrid interactions found for this protein.

    Microscopy / Localization Data

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      PROTEIN(S) PUBLICATION
    View Data COX18 Huh WK, et al. (2003)

    Protein Structure Data


    [What does the above image mean?]
    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..119] MSA 1.087991 View MSA. Confident ab initio structure predictions are available.
    2 View Details [120..316] Pfam 2.853872 60Kd inner membrane protein No confident structure predictions are available.


    Reference: Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076


    Philius Transmembrane Prediction:

    [View Details]
    Source: Reynolds et al. 2008. Manuscript submitted Philius confidence legend
    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle