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Protein Overview: SEC7

General Information:
Name(s) found: SEC7 / YDR170C [SGD]
Description(s) found:
Found 25 descriptions.
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  • Guanine nucleotide exchange factor (GEF) for ADP ribosylation factors involved in proliferation of the Golgi, intra-Golgi transport and ER-to-Golgi transport; found in the cytoplasm and on Golgi-associated coated vesicles [SGD]
    • Organism: Saccharomyces cerevisiae
    Length: 2009 amino acids

    Gene Ontology:
    Cellular Component: late endosome [IDALink to PubMed article]
    cytosol [IDALink to PubMed article]
    Golgi-associated vesicle [IDALink to PubMed article]
    Biological Process: ER to Golgi vesicle-mediated transport [IMPLink to PubMed article]
    intra-Golgi vesicle-mediated transport [IMPLink to PubMed article]
    Molecular Function: ARF guanyl-nucleotide exchange factor activity [IDALink to PubMed article]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MSEQNSVVNA EKGDGEISSN VETASSVNPS VKPQNAIKEE AKETNGEDQK CKGPENAGST  60
   61 AETKETSNDA TNGMKTPEET EDTNDKRHDD EGEDGDEDED EDEDEDEDNG DEDDEDVDSS 120
  121 SSETSSEDGE DSESVSGEST ESSSGEDEES DESDGNTSNS SSGDESGSEE EEEEEEEEEE 180
  181 EENAGEPAIA HQDSVPTNDS TAPRSTHTRN ISLSSNGSNT NSTIILVKTT LETILNDKDI 240
  241 KKNSNAQKAI ERTLQKFKEF DPQTTNNPHY VDSILVFEAL RASCRTKSSK VQSLALDCLS 300
  301 KLFSFRSLDE TLLVNPPDSL ASNDQRQDAA DGITPPPKQK IIDAAIDTIS DCFQGEGTDD 360
  361 RVELQIVRAL SSCILEEDSS SLCHGASLLK AIRTIYNVFV FSLNPSNQGI AQATLTQIIS 420
  421 SVYDKIDLKQ STSSAVSLST KNHQQQSAIE LSEASENAET PAPLTLENMD KLNDDEERLM 480
  481 DAQQPDSIAI TNQDLAVKDA FLVFRVMAKI CAKPLETELD MRSHAVRSKL LSLHIIYSII 540
  541 KDHIDVFLSH NIFLPGKERV CFIDSIRQYL RLVLSRNAAS PLAPVFEVTL EIMWLLIANL 600
  601 RADFVKEIPV FLTEIYFPIS ELTTSTSQQK RYFLSVIQRI CNDPRTLVEF YLNYDCNPGM 660
  661 PNVMEITVDY LTRLALTRVE ITQTQRSYYD EQISKSLSTY NFSQLPLLTS SNLSSSPDVG 720
  721 QVNLLFPLDF ALKMVSLNCI VSVLRSLSSW AHKALNPNTH TANKVLLNTT SSARQESRSS 780
  781 LSNDVRSSIM TSNDDFKPTY EDEESRSLSS QNIDADDPTQ FENLKLRKTA LSECIAIFNN 840
  841 KPKKAIPVLI KKGFLKDDSP ISIAKWLLET EGLDMAAVGD YLGEGDDKNI AIMHAFVDEF 900
  901 DFTGMSIVDA LRSFLQSFRL PGEGQKIDRF MLKFAERFVD QNPGVFSKAD TAYVLSYSLI 960
  961 MLNTDLHSSQ IKNKMSLQEF LENNEGIDNG RDLPRDFLEG LFNEIANNEI KLISEQHQAM1020
 1021 LSGDTNLVQQ QQSAFNFFNS RDLTREAYNQ VSKEISSKTE LVFKNLNKNK GGPDVYYAAS1080
 1081 HVEHVKSIFE TLWMSFLAAL TPPFKDYDDI DTTNKCLEGL KISIKIASTF RINDARTSFV1140
 1141 GALVQFCNLQ NLEEIKVKNV NAMVILLEVA LSEGNYLEGS WKDILLVVSQ MERLQLISKG1200
 1201 IDRDTVPDVA QARVANPRVS YESSRSNNTS FFDVWGKKAT PTELAQEKHH NQTLSPEISK1260
 1261 FISSSELVVL MDNIFTKSSE LSGNAIVDFI KALTAVSLEE IESSENASTP RMFSLQKMVD1320
 1321 VCYYNMDRIK LEWTPLWAVM GKAFNKIATN SNLAVVFFAI DSLRQLSMRF LDIEELSGFE1380
 1381 FQHDFLKPFE YTVQNSGNTE VQEMIIECFR NFILTKSESI KSGWKPILES LQYTARSSTE1440
 1441 SIVLKTQLLV SNDIVTNHFE NVFSQEDAFS ELVGVFREIT KNKRFQKLSL HALESLRKMT1500
 1501 QNVADICFYN ENKTEEERKH NDALLRGKDI FQDVWFPMLF CFNDTIMTAE DLEVRSRALN1560
 1561 YMFDALVAYG GKFNDDFWEK ICKKLLFPIF GVLSKHWEVN QFNSHDDLSV WLSTTLIQAL1620
 1621 RNLIALFTHY FESLNRMLDG FLGLLVSCIC QENDTIARIG RSCLQQLILQ NVSKFNEYHW1680
 1681 NQIGDVFDKL FDLTTANELF DYDPLQQGRK SSVSHHQTTN DTSQHSDDDS NDRRENDSNI1740
 1741 SETVERAHQE ESSEDVGGDM VETLNGQTKL NNGNSVPTVK DELNPKPASL SIPKKTKHMK1800
 1801 RNESNEDIRR RINIKNSIVV KCVLQLLMIE LLNELFENED FAHCIPYKEA IRITRLLEKS1860
 1861 YEFSRDFNED YGLRTRLVEA RVVDKIPNLL KQETSAAAVL LDIMFQLYLN DDEKKADLIT1920
 1921 RLITICIQVV EGYVSLDDRT MERSINAWRS VIVEILQGYY EFDDEDFRLY CPAMYALVIQ1980
 1981 ILDKSVPTEL RHAIKQFLSR VGELYLSTD

    Protein Complex Data

      PUBLICATION TOPOLOGY COCOMPLEXED PROTEINS
    View Details Riffle et al. (2010) (Unpublished Data) FKS1 SEC7
    View Details Hazbun TR, et al. (2003) AIM25 DED81 GWT1 MRC1 SEC63 SEC7
    View Details Krogan NJ, et al. (2006) PPX1 SEC7
    View Details Gavin AC, et al. (2006) CSE1 DHH1 SEC7
    View Details Gavin AC, et al. (2002) ADH1 ARX1 BEM2 BMS1 BRX1 BUD20 CCT4 CIC1 CLU1 CSE1 CYR1 CYS4 DBP10 DBP9 DCP2 DHH1 DRS1 DUG1 EBP2 ECM29 ERB1 FKS1 FPR4 GCN1 GCN20 GFA1 HAS1 HDA1 HER1 HIS3 IDH2 INP2 IPI1 IPI3 KAP123 KRE33 KTR3 LHP1 LOC1 LSG1 MAK21 MAK5 MDN1 MIR1 MIS1 MRT4 NAP1 NIP1 NIP7 NMD3 NOC2 NOC3 NOG1 NOG2 NOP1 NOP12 NOP15 NOP16 NOP2 NOP4 NOP56 NOP7 NSA1 NSA2 NUG1 PRT1 PUF6 REI1 RGR1 RIX1 RIX7 RLP24 RLP7 RPA135 RPA190 RPF1 RPF2 RPG1 RPP2B RPT6 RRP1 RRP12 RSA3 RSA4 RTR1 SAM1 SDA1 SEC7 SKI2 SLC1 SNU13 SPB1 SPB4 SRV2 SSF1 TIF6 TUB3 URB1 UTP10 UTP20 UTP22 YGL036W YHR020W YTM1
    View Details Ho Y, et al. (2002) ATP4 GCN1 LOS1 PEP3 POL5 PTC1 RED1 RVB1 SEC7 SIP2 SNF1 SNF4 TMA19 UBA1 UBC6 UTP20 YMR086W YPT1
    View Details Qiu et al. (2008) GEA1 SEC7

    Mass Spectrometry Data

    The following runs contain data for this protein:

      BAIT COMMENTS PUBLICATION
    View Run GWT1 No Comments Hazbun TR, et al. (2003)
    View Run MIH1 experimental1 - mih1-1 McCusker D, et al (2007)
    View Run MIH1 experimental2 - mih1-2 McCusker D, et al (2007)
    View Run RPA135 No Comments Schneider, DA, et al. (2006)
    View Run ZDS1 Sample 2- cpn2 from june 2005 McCusker D, et al (2007)
    View Run ZDS1 Sample 3 - cpn + atp, from june 2005 McCusker D, et al (2007)
    View Run BOI1 Sample boi 1 with ha tag from october 2005 McCusker D, et al (2007)
    View Run MLP2 #03 Alpha Factor Prep1-TiO2 Flowthrough Keck JM, et al. (2011)
    View Run MLP2 #29 Asynchronous Prep5-TiO2 Flowthrough Keck JM, et al. (2011)

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    SHOWING SINGLE HITS. [ Hide Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

      BAIT PREY HITS PUBLICATION
    View Screen SWI5 SEC7 1 Unpublished Fields Lab Data
    View Screen UBC7 SEC7 1 Unpublished Fields Lab Data

    Microscopy / Localization Data

    New Feature: Upload Your Own Microscopy Data

      PROTEIN(S) PUBLICATION
    View Data SEC7 Huh WK, et al. (2003)
    View Data SEC7 and CHC1 Huh WK, et al. (2003)

    Protein Structure Data


    [What does the above image mean?]
    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..355] PSI-BLAST 11.221849 Heavy meromyosin subfragment
    2 View Details [356..777] deduced N/A No confident structure predictions are available.
    3 View Details [778..897] PSI-BLAST 520.36704 Exchange factor ARNO
    4 View Details [898..1032] PSI-BLAST 520.36704 Exchange factor ARNO
    5 View Details [1033..1325] ORFEUS 13.23 Constant regulatory domain of protein phosphatase 2a, pr65alpha
    6 View Details [1326..1401] ORFEUS 13.23 Constant regulatory domain of protein phosphatase 2a, pr65alpha
    7 View Details [1402..1708] ORFEUS 13.23 Constant regulatory domain of protein phosphatase 2a, pr65alpha
    8 View Details [1709..1771] deduced N/A No confident structure predictions are available.
    9 View Details [1772..2009] MSA 1.024942 View MSA. No confident structure predictions are available.

    Functions predicted (by domain):

    # Gene Ontology predictions
    1 No functions predicted.
    2 No functions predicted.
    3 No functions predicted.
    4 No functions predicted.
    5
    Term Confidence Notes
  • ARF guanyl-nucleotide exchange factor activity
    		•  6.57705646633597 bayes_pls_golite062009
  • nucleoside-triphosphatase regulator activity
    		•  2.34270596875878 bayes_pls_golite062009
  • GTPase regulator activity
    		•  2.33775275044058 bayes_pls_golite062009
  • enzyme regulator activity
    		•  2.18282128472415 bayes_pls_golite062009
  • guanyl-nucleotide exchange factor activity
    		•  2.13694141859871 bayes_pls_golite062009
  • small GTPase regulator activity
    		•  1.9528150458215 bayes_pls_golite062009
  • binding
    		•  1.48136085083473 bayes_pls_golite062009
  • protein binding
    		•  0.709918436973955 bayes_pls_golite062009
    6 No functions predicted.
    7
    Term Confidence Notes
  • transcription regulator activity
    		•  4.23589314549461 bayes_pls_golite062009
  • transcription factor activity
    		•  3.20154674515543 bayes_pls_golite062009
  • binding
    		•  1.86110799162977 bayes_pls_golite062009
  • transcription activator activity
    		•  1.49121387344133 bayes_pls_golite062009
  • transcription repressor activity
    		•  1.37470101715384 bayes_pls_golite062009
  • nucleic acid binding
    		•  1.23329188282806 bayes_pls_golite062009
  • DNA binding
    		•  1.13681181911191 bayes_pls_golite062009
  • protein binding
    		•  1.08484616730639 bayes_pls_golite062009
  • RNA polymerase II transcription factor activity
    		•  0.716405160484334 bayes_pls_golite062009
  • structural molecule activity
    		•  0.699916732836588 bayes_pls_golite062009
  • structural constituent of ribosome
    		•  0.642134554528826 bayes_pls_golite062009
  • ligase activity
    		•  0.480312224694405 bayes_pls_golite062009
  • catalytic activity
    		•  0.22314902412029 bayes_pls_golite062009
  • transcription factor binding
    		•  0.175826195692125 bayes_pls_golite062009
  • transporter activity
    		•  0.157041289238914 bayes_pls_golite062009
  • small conjugating protein ligase activity
    		•  0.11628064315417 bayes_pls_golite062009
  • ubiquitin-protein ligase activity
    		•  0.0898225651928188 bayes_pls_golite062009
    8 No functions predicted.
    9 No functions predicted.


    Reference: Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076


    Philius Transmembrane Prediction:

    Protein predicted to be: GLOBULAR (No transmembrane regions or signal peptide)
    Confidence of classification: 0.99

    Source: Reynolds et al. (2008)

    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle