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Protein Overview: MRPL3

General Information:
Name(s) found: MRPL3 / YMR024W [SGD]
Description(s) found:
Found 23 descriptions.
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  • Mitochondrial ribosomal protein of the large subunit [SGD]
    • Organism: Saccharomyces cerevisiae
    Length: 390 amino acids

    Gene Ontology:
    Cellular Component: mitochondrion [IDALink to PubMed article]
    mitochondrial large ribosomal subunit [IPILink to PubMed article][TASLink to PubMed article]
    Biological Process: translation [TASLink to PubMed article]
    Molecular Function: structural constituent of ribosome [TASLink to PubMed article]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MGIVLKRAIA AGMKPFPNST WHWSRTIRPF SQHLSSTCFL QQSSRFTSKR YLHLSTLTQQ  60
   61 EKRFLPESEL AKYKEYYQGL KSTVNEIPES VASKSPSLRT LHKRLQLPNE LTYSTLSRCL 120
  121 TCPSAKLPDK INNPTKGAAF VNTVPTNKYL DNHGLNIMGK NLLSYHVTKS IIQKYPRLPT 180
  181 VVLNAAVNAY ISEAVLAHIA KYWGIEVETT SVLSRYLKME PFEFTLGRLK FFNNSLNSKD 240
  241 GIELITGKNF SETSALAMSV RSIIAAIWAV TEQKDSQAVY RFIDDHIMSR KLDITKMFQF 300
  301 EQPTRELAML CRREGLEKPV SKLVAESGRL SKSPVFIVHV FSGEETLGEG YGSSLKEAKA 360
  361 RAATDALMKW YCYEPLAQQE PVIDPGTVVV

    Protein Complex Data

      PUBLICATION TOPOLOGY COCOMPLEXED PROTEINS
    View Details Riffle et al. (2010) (Unpublished Data) IMG1 IMG2 MHR1 MRP20 MRP7 MRPL1 MRPL10 MRPL13 MRPL15 MRPL16 MRPL17 MRPL20 MRPL23 MRPL24 MRPL27 MRPL28 MRPL3 MRPL35 MRPL36 MRPL4 MRPL7 MRPL8 YML6
    View Details (MIPS) Mewes HW, et al. (2004) IMG1 IMG2 MNP1 MRP20 MRP49 MRP7 MRPL1 MRPL10 MRPL11 MRPL13 MRPL15 MRPL16 MRPL17 MRPL19 MRPL20 MRPL22 MRPL23 MRPL24 MRPL25 MRPL27 MRPL28 MRPL3 MRPL31 MRPL32 MRPL33 MRPL35 MRPL36 MRPL37 MRPL38 MRPL39 MRPL4 MRPL40 MRPL44 MRPL49 MRPL50 MRPL51 MRPL6 MRPL7 MRPL8 MRPL9 RML2 RTC6 YDR115W YML6
    View Details Krogan NJ, et al. (2006) IMG2 MRP20 MRPL1 MRPL10 MRPL15 MRPL25 MRPL3 MRPL4 MRPL40 MRPL9
    View Details Gavin AC, et al. (2002) AAR2 ACC1 ATG26 AVT4 BEM2 BRR1 BUD3 BUD31 CCT2 CCT8 CDC25 CDC33 CEF1 CLF1 CLU1 COP1 CPA2 CSN12 CUS1 CWC2 CWC22 CWC23 CYR1 DHH1 DIB1 ECM2 FAB1 FDH1 GCN2 GCN20 GFA1 GUS1 HRK1 HRR25 HSH155 HTA1 ILV1 IMG1 IMG2 IML1 KAP123 LEA1 LIN1 LSM1 LSM2 LSM4 LSM5 LSM6 LSM7 LUC7 LYS12 MDS3 MHR1 MIA40 MRH4 MRM1 MRP20 MRP49 MRP7 MRPL1 MRPL10 MRPL13 MRPL15 MRPL16 MRPL17 MRPL19 MRPL20 MRPL23 MRPL24 MRPL25 MRPL27 MRPL28 MRPL3 MRPL35 MRPL36 MRPL38 MRPL39 MRPL4 MRPL44 MRPL51 MRPL6 MRPL7 MRPL8 MRPS5 MSL1 MUD1 NIC96 NSP1 NUG1 NUP116 NUP159 NUP82 PAT1 PRP11 PRP18 PRP19 PRP21 PRP24 PRP28 PRP3 PRP31 PRP38 PRP39 PRP4 PRP40 PRP42 PRP43 PRP46 PRP6 PRP8 PRP9 PSA1 RET2 ROM2 RPA135 RPB2 RPN10 RPN11 RPN12 RPN8 RPT3 RPT5 RPT6 RSE1 RTC6 RVB2 SAM1 SAP155 SAP185 SAP190 SEC1 SEC26 SEC27 SIN4 SIT4 SLU7 SMB1 SMC3 SMD1 SMD2 SMD3 SME1 SMX2 SMX3 SNF2 SNP1 SNT309 SNU114 SNU23 SNU56 SNU66 SNU71 SPP381 SPP382 SRB2 STO1 SWI3 SWT21 SYF1 SYP1 TAF5 TCB1 TIF1, TIF2 TOS4 TSA1 TUB3 URA7 UTP20 UTP21 VAS1 YDR115W YML6 YOL098C
    View Details Qiu et al. (2008) IMG1 IMG2 MHR1 MNP1 MRP1 MRP10 MRP2 MRP20 MRP21 MRP4 MRP49 MRP51 MRP7 MRPL1 MRPL10 MRPL11 MRPL13 MRPL15 MRPL16 MRPL17 MRPL19 MRPL20 MRPL22 MRPL23 MRPL24 MRPL25 MRPL27 MRPL28 MRPL3 MRPL31 MRPL32 MRPL33 MRPL35 MRPL36 MRPL37 MRPL38 MRPL39 MRPL4 MRPL40 MRPL44 MRPL49 MRPL50 MRPL51 MRPL6 MRPL7 MRPL8 MRPL9 MRPS12 MRPS16 MRPS17 MRPS18 MRPS28 MRPS35 MRPS8 MRPS9 NAM9 PET123 RML2 RSM10 RSM18 RSM19 RSM22 RSM23 RSM24 RSM25 RSM26 RSM27 RSM7 RTC6 SWS2 VAR1 YDR115W YML6

    Mass Spectrometry Data

    The following runs contain data for this protein:

      BAIT COMMENTS PUBLICATION
    View Run ZDS1 Sample 2- cpn2 from june 2005 McCusker D, et al (2007)
    View Run MLP2 #33 Asynchronous SPB prep Keck JM, et al. (2011)
    View Run MLP2 #35 Asynchronous SPB prep Keck JM, et al. (2011)
    View Run MLP2 #12 Mitotic Prep1-TiO2 Flowthrough Keck JM, et al. (2011)
    View Run MLP2 #02 Alpha Factor Prep1-TiO2 enriched, new search criteria Keck JM, et al. (2011)
    View Run MLP2 #11 Mitotic Prep1-TiO2 enriched, new search criteria Keck JM, et al. (2011)

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    SHOWING SINGLE HITS. [ Hide Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

    No yeast two-hybrid interactions found for this protein.

    Microscopy / Localization Data

    New Feature: Upload Your Own Microscopy Data

      PROTEIN(S) PUBLICATION
    View Data MRPL3 Huh WK, et al. (2003)

    Protein Structure Data


    [What does the above image mean?]
    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..106] MSA 1.037993 View MSA. No confident structure predictions are available.
    2 View Details [107..299] PSI-BLAST 22.221849 RNase III endonuclease catalytic domain
    3 View Details [300..390] PSI-BLAST 12.39794 Double-stranded RNA-binding protein A, second dsRBD

    Functions predicted (by domain):

    # Gene Ontology predictions
    1 No functions predicted.
    2
    Term Confidence Notes
  • structural constituent of ribosome
    		•  6.7575603459566 bayes_pls_golite062009
  • structural molecule activity
    		•  6.24187874355454 bayes_pls_golite062009
  • RNA binding
    		•  5.07736605479017 bayes_pls_golite062009
  • binding
    		•  2.71832019206733 bayes_pls_golite062009
  • nucleic acid binding
    		•  2.45216687077957 bayes_pls_golite062009
  • protein binding
    		•  1.64057905923545 bayes_pls_golite062009
  • endoribonuclease activity
    		•  1.62086478301433 bayes_pls_golite062009
  • double-stranded RNA binding
    		•  1.46317494664076 bayes_pls_golite062009
  • DNA binding
    		•  0.770826702436345 bayes_pls_golite062009
  • transcription regulator activity
    		•  0.661231648959158 bayes_pls_golite062009
  • mRNA binding
    		•  0.404665180963566 bayes_pls_golite062009
  • cytoskeletal protein binding
    		•  0.403469167264307 bayes_pls_golite062009
  • single-stranded RNA binding
    		•  0.35650576095599 bayes_pls_golite062009
  • RNA helicase activity
    		•  0.0112094156505713 bayes_pls_golite062009
    3 No functions predicted.


    Reference: Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076


    Philius Transmembrane Prediction:

    Protein predicted to be: GLOBULAR (No transmembrane regions or signal peptide)
    Confidence of classification: 0.95

    Source: Reynolds et al. (2008)

    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle