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Protein Overview: SEN1

General Information:
Name(s) found: SEN1 / YLR430W [SGD]
Description(s) found:
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  • gi|664872|gb|AAB67502.1| Sen1p [Saccharomyces cerevisiae] [NCBI NR]
  • gi|6323462|ref|NP_013534.1| Presumed helicase required for RNA polymerase II transcription termination and processing of RNAs; homolog of Senataxin which causes Ataxia-Oculomotor Apraxia 2 and a dominant form of amyotrophic lateral sclerosis; Sen1p [Sacch [NCBI NR]
  • gi|3123282|sp|Q00416.2|SEN1_YEAST RecName: Full=Helicase SEN1; AltName: Full=tRNA-splicing endonuclease positive effector [NCBI NR]
  • pir||S53416 SEN1 protein - yeast (Saccharomyces cerevisiae) [NCBI NR]
  • Helicase SEN1 OS=Saccharomyces cerevisiae GN=SEN1 PE=1 SV=2 [Swiss-Prot]
  • SEN1 Positive effector of tRNA-splicing endonuclease [mips]
  • Presumed helicase required for RNA polymerase II transcription termination and processing of RNAs; homolog of Senataxin which causes Ataxia-Oculomotor Apraxia 2 and a dominant form of amyotrophic lateral sclerosis [SGD]
  • SEN1, Chr XII from 993429-1000124 [yeast_orfs2]
  • Chr XII from 993429-1000124 [yeastorf3.fasta]
  • (Q00416) tRNA-splicing endonuclease positive effector [4932.FASTACCERV.txt]
  • SEN1 SGDID:S0004422, Chr XII from 993430-1000125, Verified ORF [yeastflysequest.fasta]
  • Nuclear protein, putative helicase required for processing of tRNAs, rRNAs, and small nuclear RNAs; potential Cdc28p substrate [Saccharomyces cerevisiae]gi|3123282|sp|Q00416|SEN1_YEAST Helicase SEN1 (tRNA-splicing endonuclease positive effector)gi|10783 [nrdb_11152004_Chlamydomonas]
  • (Q00416) Helicase SEN1 (EC 3.6.1.-) (tRNA-splicing endonuclease positive effector) [cerv4932.FASTAC]
  • SEN1 SGDID:S000004422, Chr XII from 993430-1000125, Verified ORF, "Nuclear protein, putative helicase required for processing of tRNAs, rRNAs, and small nuclear RNAs; potential Cdc28p substrate" [SGD_S-cerevisiae_na_12-16-2005_con_reversed.fasta]
  • SEN1 SGDID:S000004422, Chr XII from 993431-1000126, Verified ORF, "Nuclear protein, putative helicase required for processing of tRNAs, rRNAs, and small nuclear RNAs; potential Cdc28p substrate" [yeast-contam.fasta]
  • SEN1 SGDID:S000004422, Chr XII from 993431-1000126, Verified ORF, "Presumed helicase required for RNA polymerase II transcription termination and processing of RNAs; homolog of Senataxin which causes Ataxia-Oculomotor Apraxia 2 and a dominant form of amyo [SGD_S-cerevisiae_na_08-19-2008_con_reversed.fasta]
  • Helicase SEN1 (tRNA-splicing endonuclease positive effector) [nr-271106-contam.fasta]
  • Nuclear protein, putative helicase required for processing of tRNAs, rRNAs, and small nuclear RNAs; potential Cdc28p substrate; Sen1p [Saccharomyces cerevisiae] [nr-271106-contam.fasta]
  • Sen1p [Saccharomyces cerevisiae] [nr-271106-contam.fasta]
  • SEN1 SGDID:S000004422, Chr XII from 993431-1000126, Verified ORF, "Presumed helicase required for RNA polymerase II transcription termination and processing of RNAs; homolog of Senataxin which causes Ataxia-Oculomotor Apraxia 2 and a dominant form of amyotrophic lateral sclerosis" [yeast-bovrabprots.fasta]
  • [chemostatdb.fasta]
  • Helicase SEN1 OS=Saccharomyces cerevisiae (strain ATCC 204508 / S288c) GN=SEN1 PE=1 SV=2 [UniProt_S_cerevisiae_20120516_05-16-2012_reversed.fasta]
  • SEN1 SGDID:S000004422, Chr XII from 993434-1000129, Genome Release 64-1-1, Verified ORF, "Presumed helicase required for RNA polymerase II transcription termination and processing of RNAs; homolog of Senataxin which causes Ataxia-Oculomotor Apraxia 2 and a dominant form of amyotrophic lateral sclerosis" [yeast-030211-contam.fasta]
  • SEN1 SGDID:S000004422, Chr XII from 993434-1000129, Genome Release 64-2-1, Verified ORF, "Presumed helicase and subunit of the Nrd1 complex (Nrd1p-Nab3p-Sen1p); complex interacts with the exosome to mediate 3' end formation of some mRNAs, snRNAs, snoRNAs, and CUTs; has a separate role in coordinating DNA replication with transcription, by associating with moving replication forks and preventing errors that occur when forks encounter transcribed regions; homolog of Senataxin, which is implicated in Ataxia-Oculomotor Apraxia 2 and a dominant form of ALS" [20141208_orf_trans.fasta]
  • YLR430W SGDID:S000004422, Chr XII from 993434-1000129, Genome Release 64-1-1, Verified ORF, "Presumed helicase required for RNA polymerase II transcription termination and processing of RNAs; homolog of Senataxin which causes Ataxia-Oculomotor Apraxia 2 and a dominant form of amyotrophic lateral sclerosis" [2016-01-SGD_Yeast_Contam_Riffle_20140507-Ska-Hec-110-tubulin.fasta]
    • Organism: Saccharomyces cerevisiae
    Length: 2231 amino acids

    Gene Ontology:
    Cellular Component: nucleus [IDALink to PubMed article]
    nuclear outer membrane [IMPLink to PubMed article]
    Biological Process: snRNA processing [IMPLink to PubMed article]
    tRNA processing [IMPLink to PubMed article]
    snoRNA processing [IMPLink to PubMed article]
    transcription termination [IMPLink to PubMed article]
    termination of RNA polymerase II transcription [IMPLink to PubMed article]
    Molecular Function: DNA-dependent ATPase activity [ISSLink to PubMed article]
    RNA helicase activity [ISSLink to PubMed article]
    RNA-dependent ATPase activity [ISSLink to PubMed article]
    RNA polymerase II transcription termination factor activity [IMPLink to PubMed article]
    5'-3' DNA helicase activity [ISSLink to PubMed article]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MNSNNPDNNN SNNINNNNKD KDIAPNSDVQ LATVYTKAKS YIPQIEQVYQ GTNPNIQEAK  60
   61 LLGELLQVLA EVPKGTHLFC DPILEPISIF SLTIFSFNEE ATATWLKNHF NPILSVCDKC 120
  121 ILNFARGKCK MLQHFAIQRH VPHEHVAKFN DIVCQWRVEA VFPILRNISV NDNTGINITN 180
  181 EIETAMYECL CNPHMLRLNK QLKATFEAIF KFFYDTKHRL LDVTNPLSIK TFISGVIFCW 240
  241 CEGSKEENEW SRAFLKDLYS RNFHINLSNL TPDIIEEVYI HILFLQNPAN WTEIVVSQFW 300
  301 SRLLPVFNLF DKDVFIEYFQ VPKNVESLKK TFKFPLEPIF KMWYNHLSKS YHDKPLDFLL 360
  361 RGLTMFLNKF GSEFWSKIEP FTFHSILDII FNRDSFPIKL IKIQDNPIVE HQTEVYFQLT 420
  421 GSVTDLLSWT LPFYHALSPS KRIQMVRKVS MAFLRIIANY PSLKSIPKAC LMNSATALLR 480
  481 AVLTIKENER AMLYKNDEFE TVLLTKTDSR ALLNNPLIQD IIIRSASNPN DFYPGLGAAS 540
  541 ASVATSTMMV LAECIDFDIL LLCHRTFKLY SGKPISEIPI STNVLENVTN KIDLRSFHDG 600
  601 PLLAKQLLVS LKNINGLLIV PSNTAVAEAH NALNQKFLLL STRLMEKFAD ILPGQLSKIL 660
  661 ADEDASQGFW SCIFSSDKHL YQAATNILYN TFDVEGRLEG ILAILNSNLT VNLKNINVML 720
  721 QRLINCEFYE PCPRAVRVLM DVVSAFVDPI SGVFANFQTL KSQNTEKEFL KFWESCWLFL 780
  781 DTIYKFTLKW ASKYDYSELE NFTKDTLDLS RSLVDSFREF SDILHDQTKN LLLNVLETFK 840
  841 NMLYWLRLSD EVLLESCVRL IISTSDLAHE KHVKVDDSLV EMMAKYASKA KRFSNKLTEQ 900
  901 QASEILQKAK IFNKALTEEV ATEAENYRKE KELSRLGKVI DLTDSVPASP SLSPSLSSTI 960
  961 ASSSAESRAD YLQRKALSSS ITGRPRVAQP KITSFGTFQS SANAKLHRTK PVKPLSKMEL1020
 1021 ARMQLLNNRV VHPPSAPAFH TKSRGLSNKN DDSSSEESDN DIESARELFA IAKAKGKGIQ1080
 1081 TVDINGKVVK RQTAAELAKQ ELEHMRKRLN VDMNPLYEII LQWDYTRNSE YPDDEPIGNY1140
 1141 SDVKDFFNSP ADYQKVMKPL LLLESWQGLC SSRDREDYKP FSIIVGNRTA VSDFYDVYAS1200
 1201 VAKQVIQDCG ISESDLIVMA YLPDFRPDKR LSSDDFKKAQ HTCLAKVRTL KNTKGGNVDV1260
 1261 TLRIHRNHSF SKFLTLRSEI YCVKVMQMTT IEREYSTLEG LEYYDLVGQI LQAKPSPPVN1320
 1321 VDAAEIETVK KSYKLNTSQA EAIVNSVSKE GFSLIQGPPG TGKTKTILGI IGYFLSTKNA1380
 1381 SSSNVIKVPL EKNSSNTEQL LKKQKILICA PSNAAVDEIC LRLKSGVYDK QGHQFKPQLV1440
 1441 RVGRSDVVNV AIKDLTLEEL VDKRIGERNY EIRTDPELER KFNNAVTKRR ELRGKLDSES1500
 1501 GNPESPMSTE DISKLQLKIR ELSKIINELG RDRDEMREKN SVNYRNRDLD RRNAQAHILA1560
 1561 VSDIICSTLS GSAHDVLATM GIKFDTVIID EACQCTELSS IIPLRYGGKR CIMVGDPNQL1620
 1621 PPTVLSGAAS NFKYNQSLFV RMEKNSSPYL LDVQYRMHPS ISKFPSSEFY QGRLKDGPGM1680
 1681 DILNKRPWHQ LEPLAPYKFF DIISGRQEQN AKTMSYTNME EIRVAIELVD YLFRKFDNKI1740
 1741 DFTGKIGIIS PYREQMQKMR KEFARYFGGM INKSIDFNTI DGFQGQEKEI ILISCVRADD1800
 1801 TKSSVGFLKD FRRMNVALTR AKTSIWVLGH QRSLAKSKLW RDLIEDAKDR SCLAYACSGF1860
 1861 LDPRNNRAQS ILRKFNVPVP SEQEDDYKLP MEYITQGPDE VKSNKDTKKR RVVDEGEEAD1920
 1921 KAVKKKKKEK KKEKKKSKAD DKKKNNKKAE SPSTSSGTKK KSSIFGGMSV PSAVVPKTFP1980
 1981 DVDSNKKAAA VVGKKKNNKH VCFSDDVSFI PRNDEPEIKV TRSLSSVLKE KQLGLKETRT2040
 2041 ISPPEISNNE DDDDEDDYTP SISDSSLMKS EANGRNNRVA SHNQNFSASI YDDPQVSQAK2100
 2101 QTQVPAAITK HRSSNSVLSG GSSRILTASD YGEPNQNGQN GANRTLSQHV GNANQYSTAP2160
 2161 VGTGELHETL PAHPQDSYPA EAEDPYDLNP HPQPQSSAFK GPGSGPTGTR NSSRRNASSS2220
 2221 PFIPKKRKPR S

    Protein Complex Data

      PUBLICATION TOPOLOGY COCOMPLEXED PROTEINS
    View Details Riffle et al. (2010) (Unpublished Data) AIR2 KEL2 NRD1 SEN1 SSE2 YPS7
    View Details Krogan NJ, et al. (2006) ARA2 AYT1 BRO1 CDC73 CTR9 GLO4 HHT1, HHT2 LEO1 PAF1 PML39 POB3 PSH1 RTF1 SEN1 SPT16 YHR035W
    View Details Gavin AC, et al. (2006) MTR4 NAB3 NRD1 SEN1 STO1
    View Details Gavin AC, et al. (2002) AIR2 BRR1 BUR2 CBC2 HTA1 KAP95 LUC7 MSH4 MUD1 NAB3 NAB6 NAM8 NPL3 NRD1 NUP60 PRP39 PRP40 PRP42 RSE1 SCP160 SEN1 SGV1 SMD1 SMD2 SMD3 SNP1 SNU56 SNU71 SRO9 SRP1 STO1 THO2 TIF4631 TIF4632 YRA2
    View Details Ho Y, et al. (2002) ARP7 CAR2 CFT1 CIC1 CLU1 DIG1 DIG2 DMA2 DUN1 ERB1 FAR1 FET4 FIN1 FIP1 FPR3 FPR4 GFA1 GLC7 GLC8 GPD1 GPD2 GPH1 GUS1 HAS1 HER1 HXT6 KEL1 KSS1 LSP1 MDM30 MHP1 MKT1 MSE1 NAP1 NSA1 PDC6 PHO84 PIL1 PIM1 PMA1 PYC1 RAD1 REG1 RGC1 RPA135 RPN10 RRP17 SAW1 SCD5 SDS22 SEC6 SEN1 SPB1 STE12 STE20 STE7 SUI2 SUI3 TEC1 UBI4 YDR239C YHR033W YTM1

    Mass Spectrometry Data

    The following runs contain data for this protein:

      BAIT COMMENTS PUBLICATION
    View Run PAN1 No Comments Toshima J, et al (2006)
    View Run CEP3 sample cbf3 from feb 2005 Sandall S, et all (2006)
    View Run RPA135 No Comments Schneider, DA, et al. (2006)
    View Run ZDS1 Sample 2- cpn2 from june 2005 McCusker D, et al (2007)
    View Run MLP2 #32 Asynchronous Prep-No Phosphopeptide enrichment Keck JM, et al. (2011)
    View Run MLP2 #29 Asynchronous Prep5-TiO2 Flowthrough Keck JM, et al. (2011)

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    NOT SHOWING SINGLE HITS. [ Show Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

      BAIT PREY HITS PUBLICATION
    View Screen RGD2 SEN1 2 Unpublished Fields Lab Data

    Microscopy / Localization Data

    New Feature: Upload Your Own Microscopy Data

      PROTEIN(S) PUBLICATION
    View Data SEN1 Huh WK, et al. (2003)

    Protein Structure Data


    [What does the above image mean?]
    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..1122] deduced N/A No confident structure predictions are available.
    2 View Details [1123..1320] MSA 1.115993 View MSA. No confident structure predictions are available.
    3 View Details [1321..1655] PSI-BLAST 97.154902 DEXX box DNA helicase
    4 View Details [1656..2033] PSI-BLAST 97.154902 DEXX box DNA helicase
    5 View Details [2034..2231] deduced N/A No confident structure predictions are available.
    6 View Details [841..1128] FFAS03 1.16 THE BLUETONGUE VIRUS (BTV) CORE BINDS DSRNA
    7 View Details [1129..1859] PSI-BLAST 138.0 No description for 2gjkA was found.
    8 View Details [1860..1966] PSI-BLAST 106.0 STRUCTURE OF DNA HELICASE
    9 View Details [1967..2231] deduced N/A No confident structure predictions are available.


    Reference: Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076


    Philius Transmembrane Prediction:

    Protein predicted to be: GLOBULAR (No transmembrane regions or signal peptide)
    Confidence of classification: 0.98

    Source: Reynolds et al. (2008)

    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle