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Protein Overview: PML39

General Information:
Name(s) found: PML39 / YML107C [SGD]
Description(s) found:
Found 20 descriptions.
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  • Protein required for nuclear retention of unspliced pre-mRNAs along with Mlp1p and Pml1p; anchored to nuclear pore complex via Mlp1p and Mlp2p; found with the subset of nuclear pores farthest from the nucleolus; may interact with ribosomes [SGD]
    • Organism: Saccharomyces cerevisiae
    Length: 334 amino acids

    Gene Ontology:
    Cellular Component: ribosome [IDALink to PubMed article]
    nuclear pore [IDALink to PubMed article]
    Biological Process: mRNA export from nucleus [IGILink to PubMed article][IMPLink to PubMed article]
    Molecular Function: molecular_function [ND]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MEKDALEVRL KSIRHSLDKN TKLLPGKYRN TLGERLITKW RYKKKSHNGS SMLPEKCKSH  60
   61 VQLYDDLVQE SSKHFVGFRL HDLRALLKRI CSIQNYTRHV LIEWDVRWVN PLTLASKGWE 120
  121 PYQSASQSQV PFKCCCCHAI MTIPLLKNGD DVADYTMKLN EKIWNSNIIG NHLQKCPWRE 180
  181 NQVDLNKEYY LSSQNLIREI ERIHTEIDRI VSGSNEFSLK RNSSRIFHYL SEKEIQKLAF 240
  241 FFDCKDYSLV GLLLLGYTKF QKDDLVQCTA CFHRASLKKL EYTEFNGHAL WCRYYNKELL 300
  301 PTMLLELIGK EDKLITKLGV GERLNKLEAV LQTL

    Protein Complex Data

      PUBLICATION TOPOLOGY COCOMPLEXED PROTEINS
    View Details Krogan NJ, et al. (2006) ARA2 AYT1 BRO1 CDC73 CTR9 GLO4 HHT1, HHT2 LEO1 PAF1 PML39 POB3 PSH1 RTF1 SEN1 SPT16 YHR035W
    View Details Qiu et al. (2008) PML39 SUS1

    Mass Spectrometry Data

    No mass spectrometry results found for this protein.

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    NOT SHOWING SINGLE HITS. [ Show Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

    No yeast two-hybrid interactions found for this protein.

    Microscopy / Localization Data

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      PROTEIN(S) PUBLICATION
    View Data PML39 Huh WK, et al. (2003)
    View Data PML39 and NIC96 Huh WK, et al. (2003)

    Protein Structure Data


    [What does the above image mean?]
    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..129] deduced N/A Confident ab initio structure predictions are available.
    2 View Details [130..334] FFAS03 0.977 Structure and Function Analysis of Peptide Antagonists of Melanoma Inhibitor of Apoptosis (ML-IAP)


    Reference: Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076


    Philius Transmembrane Prediction:

    Protein predicted to be: GLOBULAR (No transmembrane regions or signal peptide)
    Confidence of classification: 0.99

    Source: Reynolds et al. (2008)

    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle