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View Protein Complex Details

Complex Overview

Complex Member Proteins

Protein

GO Cellular Component GO Biological Process GO Molecular Function
DNA2
  • nucleus
  • nuclear chromosome, telomeric region
  • DNA repair
  • lagging strand elongation
  • DNA-dependent DNA replication
  • telomere maintenance
  • replicative cell aging
  • 5'-flap endonuclease activity
  • ATP-dependent DNA helicase activity
  • single-stranded DNA specific endodeoxyribonuclease activity
  • ECM29
  • nucleus
  • cytoplasm
  • proteasome complex
  • protein catabolic process
  • protein binding
  • KAP95
  • cytoplasm
  • nuclear pore
  • protein import into nucleus
  • nuclear pore complex assembly
  • protein transmembrane transporter activity
  • MEC1
  • nucleus
  • mitochondrion
  • DNA damage checkpoint
  • DNA replication checkpoint
  • reciprocal meiotic recombination
  • DNA recombination
  • telomere maintenance
  • telomere maintenance via recombination
  • nucleobase, nucleoside, nucleotide and nucleic acid metabolic process
  • protein kinase activity
  • MPH1
  • nucleus
  • DNA repair
  • RNA helicase activity
  • 3'-5' DNA helicase activity
  • MRPS28
  • mitochondrion
  • mitochondrial small ribosomal subunit
  • ribosomal small subunit assembly
  • translation
  • RNA binding
  • structural constituent of ribosome
  • MSH2
  • nucleus
  • nuclear chromosome
  • removal of nonhomologous ends
  • DNA recombination
  • meiotic gene conversion
  • meiotic mismatch repair
  • mismatch repair
  • chromatin silencing at silent mating-type cassette
  • mitotic recombination
  • ATPase activity
  • ATP binding
  • double-strand/single-strand DNA junction binding
  • DNA insertion or deletion binding
  • loop DNA binding
  • Y-form DNA binding
  • four-way junction DNA binding
  • guanine/thymine mispair binding
  • single base insertion or deletion binding
  • MSH6
  • nucleus
  • meiotic mismatch repair
  • mismatch repair
  • ATPase activity
  • ATP binding
  • four-way junction DNA binding
  • guanine/thymine mispair binding
  • single base insertion or deletion binding
  • PGK1
  • cytoplasm
  • mitochondrion
  • gluconeogenesis
  • glycolysis
  • phosphoglycerate kinase activity
  • RAD23
  • nucleotide-excision repair factor 2 complex
  • mitochondrion
  • repairosome
  • proteasome complex
  • nucleotide-excision repair, DNA damage recognition
  • negative regulation of protein catabolic process
  • ER-associated protein catabolic process
  • damaged DNA binding
  • protein binding, bridging
  • RAD34
  • nucleus
  • nucleotide-excision repair
  • molecular_function
  • RAD4
  • nucleotide-excision repair factor 2 complex
  • repairosome
  • nucleotide-excision repair, DNA damage recognition
  • damaged DNA binding
  • RAD52
  • nucleus
  • nuclear chromosome
  • meiotic DNA recombinase assembly
  • double-strand break repair via break-induced replication
  • double-strand break repair via single-strand annealing
  • telomere maintenance via recombination
  • double-strand break repair via synthesis-dependent strand annealing
  • DNA recombinase assembly
  • postreplication repair
  • DNA strand annealing activity
  • recombinase activity
  • RFA1
  • chromosome, telomeric region
  • nucleus
  • cytoplasm
  • DNA replication factor A complex
  • DNA strand elongation involved in DNA replication
  • double-strand break repair via homologous recombination
  • DNA recombination
  • nucleotide-excision repair
  • telomere maintenance via recombination
  • DNA unwinding involved in replication
  • postreplication repair
  • DNA replication, synthesis of RNA primer
  • damaged DNA binding
  • single-stranded DNA binding
  • RFA2
  • chromosome, telomeric region
  • DNA replication factor A complex
  • DNA strand elongation involved in DNA replication
  • double-strand break repair via homologous recombination
  • DNA recombination
  • nucleotide-excision repair
  • DNA unwinding involved in replication
  • postreplication repair
  • DNA replication, synthesis of RNA primer
  • DNA binding
  • RPN10
  • proteasome regulatory particle, base subcomplex
  • proteasome complex
  • ubiquitin-dependent protein catabolic process
  • endopeptidase activity
  • RPN12
  • proteasome regulatory particle, lid subcomplex
  • ubiquitin-dependent protein catabolic process
  • endopeptidase activity
  • RPN3
  • proteasome regulatory particle, lid subcomplex
  • ubiquitin-dependent protein catabolic process
  • molecular_function
  • RPN6
  • proteasome regulatory particle, lid subcomplex
  • ubiquitin-dependent protein catabolic process
  • structural molecule activity
  • RPN8
  • proteasome regulatory particle, lid subcomplex
  • ubiquitin-dependent protein catabolic process
  • molecular_function
  • RPN9
  • proteasome regulatory particle, lid subcomplex
  • ubiquitin-dependent protein catabolic process
  • structural molecule activity
  • RPT2
  • nucleus
  • proteasome regulatory particle, base subcomplex
  • ubiquitin-dependent protein catabolic process
  • ATPase activity
  • endopeptidase activity
  • RPT3
  • proteasome regulatory particle, base subcomplex
  • ubiquitin-dependent protein catabolic process
  • ATPase activity
  • endopeptidase activity
  • RPT6
  • nucleus
  • proteasome regulatory particle, base subcomplex
  • ubiquitin-dependent protein catabolic process
  • ATPase activity
  • endopeptidase activity
  • SRO7
  • cytosol
  • plasma membrane
  • small GTPase mediated signal transduction
  • Golgi to plasma membrane transport
  • exocytosis
  • SNARE binding
  • Rab GTPase binding
  • SSL1
  • holo TFIIH complex
  • nucleotide-excision repair factor 3 complex
  • negative regulation of transcription from RNA polymerase II promoter, mitotic
  • nucleotide-excision repair, DNA duplex unwinding
  • nucleotide-excision repair
  • transcription initiation from RNA polymerase II promoter
  • general RNA polymerase II transcription factor activity
  • TFA1
  • mitochondrion
  • transcription factor TFIIE complex
  • transcription initiation from RNA polymerase II promoter
  • general RNA polymerase II transcription factor activity
  • TFB1
  • holo TFIIH complex
  • nucleotide-excision repair factor 3 complex
  • negative regulation of transcription from RNA polymerase II promoter, mitotic
  • nucleotide-excision repair, DNA duplex unwinding
  • nucleotide-excision repair
  • transcription initiation from RNA polymerase II promoter
  • general RNA polymerase II transcription factor activity
  • TFB4
  • holo TFIIH complex
  • negative regulation of transcription from RNA polymerase II promoter, mitotic
  • transcription initiation from RNA polymerase II promoter
  • general RNA polymerase II transcription factor activity
  • Cellular Component Analysis

    Given the number of proteins in the complex (A), total proteins annotated with a given GO term (B), and the total number of annotated proteins (T); the p-value represents the chances of randomly having the number of proteins in the complex annotated with a specific GO term (I).

    Only showing terms with a p-value less than or equal to 0.01.

    GO Term

    P-value

    A

    B

    I

    T

    proteasome complex 4.6663E-17 29 48 11 6292
    proteasome regulatory particle 1.8564E-16 29 23 9 6292
    proteasome accessory complex 1.8564E-16 29 23 9 6292
    proteasome regulatory particle, lid subcomplex 3.5897E-10 29 10 5 6292
    protein complex 2.1193E-8 29 1137 19 6292
    proteasome regulatory particle, base subcomplex 4.5145E-8 29 9 4 6292
    macromolecular complex 1.4496E-6 29 1635 20 6292
    nucleotide-excision repair complex 2.0639E-6 29 21 4 6292
    holo TFIIH complex 1.034E-5 29 10 3 6292
    nucleotide-excision repair factor 2 complex 2.0514E-5 29 2 2 6292
    DNA replication factor A complex 6.1366E-5 29 3 2 6292
    DNA-directed RNA polymerase II, holoenzyme 1.133E-4 29 56 4 6292
    repairosome 1.2238E-4 29 4 2 6292
    chromosome, telomeric region 2.3908E-4 29 27 3 6292
    nucleus 2.562E-4 29 2041 19 6292
    transcription factor complex 2.8574E-4 29 71 4 6292
    nucleotide-excision repair factor 3 complex 4.2467E-4 29 7 2 6292
    intracellular part 8.7176E-4 29 4938 29 6292
    intracellular 1.0831E-3 29 4975 29 6292
    nuclear part 2.1952E-3 29 1103 12 6292
    replisome 2.9982E-3 29 18 2 6292
    nuclear replisome 2.9982E-3 29 18 2 6292
    nuclear chromosome 3.4834E-3 29 228 5 6292
    nuclear replication fork 3.7021E-3 29 20 2 6292
    chromosome 7.5884E-3 29 274 5 6292
    transcription factor TFIIE complex 9.1975E-3 29 2 1 6292

    Biological Process Analysis

    Given the number of proteins in the complex (A), total proteins annotated with a given GO term (B), and the total number of annotated proteins (T); the p-value represents the chances of randomly having the number of proteins in the complex annotated with a specific GO term (I).

    Only showing terms with a p-value less than or equal to 0.01.

    GO Term

    P-value

    A

    B

    I

    T

    response to DNA damage stimulus 8.3468E-12 29 236 13 6292
    DNA repair 1.526E-11 29 192 12 6292
    cellular response to stress 1.1349E-10 29 290 13 6292
    nucleotide-excision repair 2.3196E-10 29 38 7 6292
    protein catabolic process 2.9025E-10 29 189 11 6292
    modification-dependent protein catabolic process 8.7922E-10 29 156 10 6292
    ubiquitin-dependent protein catabolic process 8.7922E-10 29 156 10 6292
    proteolysis involved in cellular protein catabolic process 1.0608E-9 29 159 10 6292
    modification-dependent macromolecule catabolic process 1.4385E-9 29 164 10 6292
    cellular protein catabolic process 2.1676E-9 29 171 10 6292
    macromolecule catabolic process 2.2047E-9 29 294 12 6292
    cellular response to stimulus 3.1514E-9 29 379 13 6292
    proteolysis 5.4645E-9 29 188 10 6292
    macromolecule metabolic process 6.6751E-9 29 2349 26 6292
    cellular macromolecule catabolic process 1.0606E-8 29 265 11 6292
    cellular macromolecule metabolic process 4.0073E-8 29 2285 25 6292
    catabolic process 8.152E-8 29 496 13 6292
    response to stress 8.3498E-8 29 497 13 6292
    primary metabolic process 9.4507E-8 29 2896 27 6292
    DNA metabolic process 5.6888E-7 29 585 13 6292
    metabolic process 8.4522E-7 29 3157 27 6292
    cellular catabolic process 1.0541E-6 29 415 11 6292
    DNA geometric change 1.6761E-6 29 20 4 6292
    DNA duplex unwinding 1.6761E-6 29 20 4 6292
    cellular metabolic process 3.1044E-6 29 3033 26 6292
    regulation of transcription from RNA polymerase II promoter, mitotic 4.8552E-6 29 8 3 6292
    negative regulation of transcription from RNA polymerase II promoter, mitotic 4.8552E-6 29 8 3 6292
    regulation of transcription, mitotic 7.2602E-6 29 9 3 6292
    negative regulation of transcription, mitotic 7.2602E-6 29 9 3 6292
    response to stimulus 1.2203E-5 29 766 13 6292
    mitotic recombination 1.3582E-5 29 33 4 6292
    telomere maintenance via recombination 4.7361E-5 29 16 3 6292
    transcription initiation from RNA polymerase II promoter 5.662E-5 29 47 4 6292
    postreplication repair 6.8585E-5 29 18 3 6292
    double-strand break repair via homologous recombination 1.2784E-4 29 22 3 6292
    DNA conformation change 1.3004E-4 29 58 4 6292
    transcription initiation 1.3004E-4 29 58 4 6292
    DNA recombination 1.5002E-4 29 114 5 6292
    negative regulation of macromolecule metabolic process 1.9732E-4 29 192 6 6292
    DNA replication, synthesis of RNA primer 2.0338E-4 29 5 2 6292
    recombinational repair 2.1318E-4 29 26 3 6292
    macromolecular complex assembly 2.1977E-4 29 281 7 6292
    nucleotide-excision repair, DNA duplex unwinding 3.042E-4 29 6 2 6292
    negative regulation of metabolic process 3.2119E-4 29 210 6 6292
    DNA strand elongation 3.6289E-4 29 31 3 6292
    DNA strand elongation involved in DNA replication 3.6289E-4 29 31 3 6292
    nucleotide-excision repair, DNA damage recognition 4.2467E-4 29 7 2 6292
    meiosis I 4.3074E-4 29 79 4 6292
    cellular process 4.8039E-4 29 4426 28 6292
    DNA-dependent DNA replication 4.9666E-4 29 82 4 6292
    nucleic acid metabolic process 5.3506E-4 29 1415 15 6292
    protein complex biogenesis 6.2599E-4 29 155 5 6292
    protein complex assembly 6.2599E-4 29 155 5 6292
    meiotic mismatch repair 7.2384E-4 29 9 2 6292
    negative regulation of biological process 8.6691E-4 29 253 6 6292
    macromolecular complex subunit organization 9.3905E-4 29 357 7 6292
    negative regulation of macromolecule biosynthetic process 1.0852E-3 29 175 5 6292
    negative regulation of nitrogen compound metabolic process 1.2315E-3 29 180 5 6292
    negative regulation of nucleobase, nucleoside, nucleotide and nucleic acid metabolic process 1.2315E-3 29 180 5 6292
    cellular component assembly 1.4643E-3 29 385 7 6292
    negative regulation of biosynthetic process 1.5311E-3 29 189 5 6292
    negative regulation of cellular biosynthetic process 1.5311E-3 29 189 5 6292
    nucleobase, nucleoside, nucleotide and nucleic acid metabolic process 1.659E-3 29 1566 15 6292
    DNA unwinding involved in replication 1.8037E-3 29 14 2 6292
    double-strand break repair 2.1796E-3 29 57 3 6292
    DNA replication 2.2625E-3 29 123 4 6292
    negative regulation of cellular metabolic process 2.3867E-3 29 209 5 6292
    negative regulation of transcription from RNA polymerase II promoter 2.5255E-3 29 60 3 6292
    protein metabolic process 2.8456E-3 29 1136 12 6292
    pore complex assembly 4.609E-3 29 1 1 6292
    nuclear pore complex assembly 4.609E-3 29 1 1 6292
    meiotic gene conversion 4.609E-3 29 1 1 6292
    negative regulation of cellular process 5.1647E-3 29 250 5 6292
    negative regulation of transcription, DNA-dependent 5.4484E-3 29 157 4 6292
    negative regulation of RNA metabolic process 5.5722E-3 29 158 4 6292
    meiosis 5.8254E-3 29 160 4 6292
    M phase of meiotic cell cycle 5.8254E-3 29 160 4 6292
    cellular protein metabolic process 5.9318E-3 29 1074 11 6292
    cellular nitrogen compound metabolic process 6.0446E-3 29 1770 15 6292
    negative regulation of transcription 6.3547E-3 29 164 4 6292
    meiotic cell cycle 6.3547E-3 29 164 4 6292
    negative regulation of gene expression 6.3547E-3 29 164 4 6292
    mismatch repair 6.7039E-3 29 27 2 6292
    nitrogen compound metabolic process 6.8136E-3 29 1791 15 6292
    RNA biosynthetic process 6.9861E-3 29 508 7 6292
    negative regulation of catabolic process 9.1975E-3 29 2 1 6292
    negative regulation of protein catabolic process 9.1975E-3 29 2 1 6292

    Molecular Function Analysis

    Given the number of proteins in the complex (A), total proteins annotated with a given GO term (B), and the total number of annotated proteins (T); the p-value represents the chances of randomly having the number of proteins in the complex annotated with a specific GO term (I).

    Only showing terms with a p-value less than or equal to 0.01.

    GO Term

    P-value

    A

    B

    I

    T

    endopeptidase activity 3.915E-6 29 54 5 6292
    damaged DNA binding 1.4173E-5 29 11 3 6292
    single base insertion or deletion binding 2.0514E-5 29 2 2 6292
    structure-specific DNA binding 4.3507E-5 29 44 4 6292
    guanine/thymine mispair binding 6.1366E-5 29 3 2 6292
    peptidase activity, acting on L-amino acid peptides 6.292E-5 29 95 5 6292
    four-way junction DNA binding 1.2238E-4 29 4 2 6292
    DNA binding 1.2291E-4 29 256 7 6292
    double-stranded DNA binding 1.4656E-4 29 23 3 6292
    general RNA polymerase II transcription factor activity 1.9106E-4 29 64 4 6292
    mismatched DNA binding 2.0338E-4 29 5 2 6292
    DNA insertion or deletion binding 2.0338E-4 29 5 2 6292
    ATPase activity 3.2954E-4 29 211 6 6292
    nucleoside-triphosphatase activity 5.7621E-4 29 329 7 6292
    DNA secondary structure binding 7.2384E-4 29 9 2 6292
    hydrolase activity, acting on acid anhydrides 8.7828E-4 29 353 7 6292
    hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides 8.7828E-4 29 353 7 6292
    pyrophosphatase activity 8.7828E-4 29 353 7 6292
    peptidase activity 1.6421E-3 29 192 5 6292
    single-stranded DNA binding 2.365E-3 29 16 2 6292
    RNA polymerase II transcription factor activity 2.7684E-3 29 130 4 6292
    ATP binding 5.3167E-3 29 24 2 6292
    adenyl ribonucleotide binding 5.7626E-3 29 25 2 6292
    adenyl nucleotide binding 8.2376E-3 29 30 2 6292
    nucleic acid binding 8.6063E-3 29 666 8 6292
    purine nucleoside binding 8.7807E-3 29 31 2 6292
    phosphoglycerate kinase activity 9.1975E-3 29 2 1 6292
    3'-5' DNA helicase activity 9.1975E-3 29 2 1 6292
    nucleoside binding 9.3395E-3 29 32 2 6292

    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle