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Any process that stops, prevents or reduces the frequency, rate or extent of cell growth. Any process that decreases the rate of the directed movement of calcium ions into the cytosol of a cell. The cytosol is that part of the cytoplasm that does not contain membranous or particulate subcellular components. Any process that decreases the frequency, rate or extent of disassembly of the SNARE complex. The SNARE complex is a protein complex involved in membrane fusion; a stable ternary complex consisting of a four-helix bundle, usually formed from one R-SNARE and three Q-SNAREs with an ionic layer sandwiched between hydrophobic layers. Any process that stops, prevents or reduces the frequency, rate or extent of the transport of proteins from the Golgi to the plasma membrane. Any process that stops, prevents or reduces the frequency, rate or extent of the process by which bicoid mRNA is transported to, or maintained in, a specific location. Any process that decreases the frequency, rate or extent of transposition. Transposition results in the movement of discrete segments of DNA between nonhomologous sites. Any process that stops, prevents or reduces the frequency, rate or extent of a process by which oskar mRNA is transported to, or maintained in, the oocyte pole plasm. Any process that stops, prevents or reduces the frequency, rate or extent of the regulated release of a hormone from a cell or group of cells. Any process that stops, prevents or reduces the frequency, rate or extent of exocytosis. Any process that stops, prevents or reduces the frequency, rate or extent of synapse structural plasticity. Any process that decreases the rate, frequency or extent of a cellular process that is involved in the progression of biochemical and morphological phases and events that occur in a cell during successive cell replication or nuclear replication events. Any process that modulates the frequency, rate or extent of a biological process. Biological processes are regulated by many means; examples include the control of gene expression, protein modification or interaction with a protein or substrate molecule. Any process that decreases the rate or frequency of cell death. Cell death is the specific activation or halting of processes within a cell so that its vital functions markedly cease, rather than simply deteriorating gradually over time, which culminates in cell death. Any process that stops, prevents or reduces the frequency, rate or extent of cell division. Any process that decreases the rate, frequency, or extent of dendritic spine morphogenesis, the process by which the anatomical structures of a dendritic spine are generated and organized. A dendritic spine is a protrusion from a dendrite and a specialized subcellular compartment involved in synaptic transmission. Any process that stops, prevents or reduces the frequency, rate or extent of synaptogenesis, the formation of a synapse. Any process that is carried out at the cellular level, but not necessarily restricted to a single cell. For example, cell communication occurs among more than one cell, but occurs at the cellular level. Any process that decreases the rate, frequency, or extent of gene silencing, the transcriptional or post-transcriptional process carried out at the cellular level that results in long-term gene inactivation. Any process that stops, prevents or reduces the rate or extent of progression through the cell cycle. Any process that stops, prevents or reduces the frequency, rate or extent of the regulated release of a neurotransmitter. Any process that stops, prevents or reduces the frequency, rate or extent of the regulated release of serotonin. Any process that decreases the rate, frequency, or extent of the aggregation, arrangement and bonding together of proteins and RNA molecules to form a cytoplasmic mRNA processing body. Any process that stops, prevents or reduces the frequency, rate or extent of a process involved in the formation, arrangement of constituent parts, or disassembly of cell projections. Any process that decreases the frequency, rate or extent of synaptic vesicle priming. Synaptic vesicle priming is the formation of SNARE-containing complexes, bringing synaptic vesicle membrane and plasma membranes into close proximity and thereby facilitating membrane fusion. Any process that stops, prevents or reduces the frequency, rate or extent of the process of creating protein polymers. Any process that stops, prevents or reduces the frequency, rate or extent of the controlled release of a protein from a cell or group of cells. Any process that stops, prevents or reduces the frequency, rate or extent of cell differentiation. Any process that stops, prevents or reduces the rate or extent of cell proliferation. Any process that decreases the rate, frequency, or extent of a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a growth factor stimulus. Any process that stops, prevents or reduces the frequency, rate or extent of the controlled release of glutamate. Any process that stops, prevents or reduces the frequency, rate or extent of the regulated release of gamma-aminobutyric acid. Any process that stops, prevents or reduces the frequency, rate or extent of a biological process. Biological processes are regulated by many means; examples include the control of gene expression, protein modification or interaction with a protein or substrate molecule. Any process that decreases the rate, frequency, or extent the controlled release of molecules that form the extracellular matrix, including carbohydrates and glycoproteins by a cell or a group of cells. Any process that decreases the rate, frequency or extent of extracellular matrix disassembly. Extracellular matrix disassembly is a process that results in the breakdown of the extracellular matrix. Any process that stops, prevents or reduces the frequency, rate or extent of symbiont cell wall strengthening during entry into host. The host is defined as the larger of the organisms involved in a symbiotic interaction. Any process that stops, prevents or reduces the rate or extent of exocyst assembly. Any process that decreases the frequency, rate or extent of cell communication. Cell communication is the process that mediates interactions between a cell and its surroundings. Encompasses interactions such as signaling or attachment between one cell and another cell, between a cell and an extracellular matrix, or between a cell and any other aspect of its environment. Any process that decreases the rate, frequency or extent of cell adhesion molecule production. Cell adhesion molecule production is the appearance of a cell adhesion molecule as a result of its biosynthesis or a decrease in its catabolism. Any process that stops, prevents or reduces the frequency, rate or extent of the change in the membrane potential of the mitochondria from negative to positive. Any process that stops, prevents or reduces the frequency, rate or extent of endocytosis. Any process that stops, prevents or reduces the frequency, rate or extent of the directed movement of a solute from one side of a membrane to the other. Any process that decreases the frequency, rate or extent of the formation of a syncytium, a mass of cytoplasm containing several nuclei enclosed within a single plasma membrane, by the fusion of the plasma membranes of two or more individual cells. Any process that stops, prevents or reduces the frequency, rate or extent of the formation of a myelin sheath around nerve axons. Any process that stops, prevents or reduces the frequency, rate or extent of cell activation. Any process that decreases the rate, frequency or extent of ribosome biogenesis. Ribosome biogenesis is the process of the formation of the constituents of the ribosome subunits, their assembly, and their transport to the sites of protein synthesis. Any process that stops, prevents or reduces the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of integrins. Any process that stops, prevents or reduces the frequency, rate or extent of chromosome segregation, the process by which genetic material, in the form of chromosomes, is organized and then physically separated and apportioned to two or more sets. Any process that stops or prevents the binding and fusion of a sperm to the oocyte plasma membrane. Any process that stops, prevents or reduces the frequency, rate or extent of a cellular process, any of those that are carried out at the cellular level, but are not necessarily restricted to a single cell. For example, cell communication occurs among more than one cell, but occurs at the cellular level. Any process that stops, prevents or reduces the frequency, rate or extent of neuron maturation. Any process that stops, prevents, or reduces the frequency, rate, or extent of a process that reduces the internal pH of a cell. Any process that stops, prevents or reduces the frequency, rate or extent of the chemical reactions and pathways by which individual cells transform chemical substances. Any process that stops, prevents or reduces the frequency, rate or extent of the regulated release of a catecholamine. Any process that decreases the frequency, rate or extent of a process involved in the formation, arrangement of constituent parts, or disassembly of an organelle. Any process that decreases the frequency, rate or extent of assembly of the SNARE complex. The SNARE complex is a protein complex involved in membrane fusion; a stable ternary complex consisting of a four-helix bundle, usually formed from one R-SNARE and three Q-SNAREs with an ionic layer sandwiched between hydrophobic layers. Any process specifically pertinent to the functioning of integrated living units: cells, tissues, organs, and organisms. A process is a collection of molecular events with a defined beginning and end. Any process that stops, prevents or reduces the frequency, rate or extent of cell adhesion. Any process that modulates the frequency, rate or extent of a cellular process, any of those that are carried out at the cellular level, but are not necessarily restricted to a single cell. For example, cell communication occurs among more than one cell, but occurs at the cellular level. Any process that decreases the frequency, rate or extent of the directed movement of a protein to a specific location in the plasma membrane. Any process that decreases the frequency, rate or extent of the translocation, or flipping, of phospholipid molecules from one monolayer of a membrane bilayer to the opposite monolayer. Any process that stops, prevents or reduces the frequency, rate or extent of the movement of a cellular component.

View Gene Ontology (GO) Term

GO TERM SUMMARY
Name: negative regulation of cellular process
Acc: GO:0048523
Aspect: Biological Process
Desc: Any process that stops, prevents or reduces the frequency, rate or extent of a cellular process, any of those that are carried out at the cellular level, but are not necessarily restricted to a single cell. For example, cell communication occurs among more than one cell, but occurs at the cellular level.
Synonyms:
  • down-regulation of cellular process
  • GO:0051243
  • downregulation of cellular process
  • negative regulation of cellular physiological process
  • down regulation of cellular process
  • inhibition of cellular process
Proteins in PDR annotated with:
   This term: 1 [Search]
   Term or descendants: 5081 [Refine Search]


[geneontology.org]
INTERACTIVE GO GRAPH

GO:0048523 - negative regulation of cellular process (interactive image map)
YRC Informatics Platform - Version 3.0
Created and Maintained by: Michael Riffle