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A large multisubunit complex which catalyzes protein degradation. This complex consists of the barrel shaped proteasome core complex and one or two associated proteins or complexes that act in regulating entry into or exit from the core. A multisubunit complex, which caps one or both ends of the proteasome core complex. This complex recognizes and unfolds ubiquitinated proteins, and translocates them to the proteasome core complex. The regulatory subcomplex of a proteasome located in the endoplasmic reticulum of a cell. The regulatory subcomplex of a proteasome located in the nucleus of a cell. The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm. Any macromolecular complex composed of two or more polypeptide subunits, which may or may not be identical. Protein complexes may have other associated non-protein prosthetic groups, such as nucleotides, metal ions or other small molecules. A multisubunit complex located in the cytosol of a cell, which caps one or both ends of the proteasome core complex. This complex recognizes, unfolds ubiquitinated proteins and translocates them to the proteasome core complex. A stable assembly of two or more macromolecules, i.e. proteins, nucleic acids, carbohydrates or lipids, in which the constituent parts function together. Any constituent part of a cell, the basic structural and functional unit of all organisms. The subcomplex of the proteasome regulatory particle that forms the peripheral lid, which is added on top of the base subcomplex. The subcomplex of the proteasome regulatory particle that directly associates with the proteasome core complex. Any constituent part of the living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm. A protein complex, that caps one or both ends of the proteasome core complex and regulates entry into, or exit from, the proteasome core complex.

View Gene Ontology (GO) Term

GO TERM SUMMARY
Name: proteasome regulatory particle
Acc: GO:0005838
Aspect: Cellular Component
Desc: A multisubunit complex, which caps one or both ends of the proteasome core complex. This complex recognizes and unfolds ubiquitinated proteins, and translocates them to the proteasome core complex.
Synonyms:
  • PA700 proteasome activator
  • PA700-dependent proteasome activator
  • modulator complex
  • 19S regulatory particle
Proteins in PDR annotated with:
   This term: 58 [Search]
   Term or descendants: 145 [Search]


[geneontology.org]
INTERACTIVE GO GRAPH

GO:0005838 - proteasome regulatory particle (interactive image map)
YRC Informatics Platform - Version 3.0
Created and Maintained by: Michael Riffle