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Protein Overview: HDA1

General Information:
Name(s) found: HDA1 / YNL021W [SGD]
Description(s) found:
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  • gi|6324307|ref|NP_014377.1| Putative catalytic subunit of a class II histone deacetylase complex that also contains Hda2p and Hda3p; Hda1p interacts with the Hda2p-Hda3p subcomplex to form an active tetramer; deletion increases histone H2B, H3 and H4 acet [NCBI NR]
  • pir||S62933 hypothetical protein YNL021w - yeast (Saccharomyces cerevisiae) [NCBI NR]
  • gi|1730711|sp|P53973.1|HDA1_YEAST RecName: Full=Histone deacetylase HDA1 [NCBI NR]
  • gi|1301851|emb|CAA95883.1| HDA1 [Saccharomyces cerevisiae] [NCBI NR]
  • Histone deacetylase HDA1 OS=Saccharomyces cerevisiae GN=HDA1 PE=1 SV=1 [Swiss-Prot]
  • HDA1 Histone deacetylase A [mips]
  • Putative catalytic subunit of a class II histone deacetylase complex that also contains Hda2p and Hda3p; Hda1p interacts with the Hda2p-Hda3p subcomplex to form an active tetramer; deletion increases histone H2B, H3 and H4 acetylation [SGD]
  • HDA1, Chr XIV from 593223-595343 [yeast_orfs2]
  • Chr XIV from 593223-595343 [yeastorf3.fasta]
  • (P53973) Histone deacetylase HDA1 [4932.FASTACCERV.txt]
  • HDA1 SGDID:S0004966, Chr XIV from 593225-595345, Verified ORF [yeastflysequest.fasta]
  • HDA1 SGDID:S0004966, Chr XIV from 593226-595346, Verified ORF [10112005cervSGD.fasta]
  • Hda1p [Saccharomyces cerevisiae]gi|1301851|emb|CAA95883.1| HDA1 [Saccharomyces cerevisiae]gi|1730711|sp|P53973|HDA1_YEAST Histone deacetylase HDA1gi|2131864|pir||S62933 hypothetical protein YNL021w - yeast (Saccharomyces cerevisiae) [nrdb_11152004_Chlamydomonas]
  • HDA1 SGDID:S000004966, Chr XIV from 593228-595348, Verified ORF, "Putative catalytic subunit of a class II histone deacetylase complex that also contains Hda2p and Hda3p; Hda1p interacts with the Hda2p-Hda3p subcomplex to form an active tetramer; deletion [SGD_S-cerevisiae_na_12-16-2005_con_reversed.fasta]
  • Histone deacetylase HDA1 [nr-271106-contam.fasta]
  • HDA1 [Saccharomyces cerevisiae] [nr-271106-contam.fasta]
  • Putative catalytic subunit of a class II histone deacetylase complex that also contains Hda2p and Hda3p; Hda1p interacts with the Hda2p-Hda3p subcomplex to form an active tetramer; deletion increases histone H2B, H3 and H4 acetylation; Hda1p [Saccharomyce [nr-271106-contam.fasta]
  • HDA1 SGDID:S000004966, Chr XIV from 593229-595349, Verified ORF, "Putative catalytic subunit of a class II histone deacetylase complex that also contains Hda2p and Hda3p; Hda1p interacts with the Hda2p-Hda3p subcomplex to form an active tetramer; deletion [SGD_S-cerevisiae_na_01-05-2010_reversed.fasta]
  • HDA1 SGDID:S000004966, Chr XIV from 593228-595348, Verified ORF, "Putative catalytic subunit of a class II histone deacetylase complex that also contains Hda2p and Hda3p; Hda1p interacts with the Hda2p-Hda3p subcomplex to form an active tetramer; deletion increases histone H2B, H3 and H4 acetylation" [yeast-bovrabprots.fasta]
  • [chemostatdb.fasta]
  • HDA1 SGDID:S000004966, Chr XIV from 593229-595349, Verified ORF, "Putative catalytic subunit of a class II histone deacetylase complex that also contains Hda2p and Hda3p; Hda1p interacts with the Hda2p-Hda3p subcomplex to form an active tetramer; deletion increases histone H2B, H3 and H4 acetylation" [SGDyeast.20101221.fasta]
  • Histone deacetylase HDA1 OS=Saccharomyces cerevisiae (strain ATCC 204508 / S288c) GN=HDA1 PE=1 SV=1 [UniProt_S_cerevisiae_20120516_05-16-2012_reversed.fasta]
  • HDA1 SGDID:S000004966, Chr XIV from 593227-595347, Genome Release 64-1-1, Verified ORF, "Putative catalytic subunit of a class II histone deacetylase complex that also contains Hda2p and Hda3p; Hda1p interacts with the Hda2p-Hda3p subcomplex to form an active tetramer; deletion increases histone H2B, H3 and H4 acetylation" [yeast-030211-contam.fasta]
  • HDA1 SGDID:S000004966, Chr XIV from 593227-595347, Genome Release 64-2-1, Verified ORF, "Putative catalytic subunit of a class II histone deacetylase complex; role in azole resistance via Hsp90p, and in the heat shock response; Hda1p interacts with the Hda2p-Hda3p subcomplex to form an active tetramer; deletion increases histone H2B, H3 and H4 acetylation; other members of the HDA1 histone deacetylase complex are Hda2p and Hda3p" [20141208_orf_trans.fasta]
  • TR7039|c0_g1_i1|g.4881 ORF TR7039|c0_g1_i1|g.4881 TR7039|c0_g1_i1|m.4881 type:complete len:707 (+) TR7039|c0_g1_i1:143-2263(+) [Y12_S_cerevisiae-Sep2015-contam.fasta]
  • TR6423|c0_g1_i1|g.4600 ORF TR6423|c0_g1_i1|g.4600 TR6423|c0_g1_i1|m.4600 type:complete len:707 (+) TR6423|c0_g1_i1:168-2288(+) [DBVPG6044_S_cerevisiae-Sep2015-contam.fasta]
  • YNL021W SGDID:S000004966, Chr XIV from 593227-595347, Genome Release 64-1-1, Verified ORF, "Putative catalytic subunit of a class II histone deacetylase complex that also contains Hda2p and Hda3p; Hda1p interacts with the Hda2p-Hda3p subcomplex to form an active tetramer; deletion increases histone H2B, H3 and H4 acetylation" [2016-01-SGD_Yeast_Contam_Riffle_20140507-Ska-Hec-110-tubulin.fasta]
  • asmbl_5267|g.4004 ORF asmbl_5267|g.4004 asmbl_5267|m.4004 type:complete len:707 (+) asmbl_5267:167-2287(+) [DBVPG6044_Trinity_v2_2_0_PASA_6May2016-contam.fasta]
  • ID=asmbl_5266|g.3326 ORF ID=asmbl_5266|g.3326 ID=asmbl_5266|m.3326 type:complete len:707 (+) ID=asmbl_5266:167-2287(+) [DBVPG6044_quiverGenomes_Trinity_v2_2_0_PASA_2June2016-contam.fasta]
  • ID=asmbl_5983|g.3806 ORF ID=asmbl_5983|g.3806 ID=asmbl_5983|m.3806 type:complete len:707 (+) ID=asmbl_5983:163-2283(+) [Y12_quiver_Trinity_v2_2_0_PASA_2June2016-contam.fasta]
    • Organism: Saccharomyces cerevisiae
    Length: 706 amino acids

    Gene Ontology:
    Cellular Component: histone deacetylase complex [IDALink to PubMed article]
    Biological Process: loss of chromatin silencing involved in replicative cell aging [IMPLink to PubMed article]
    regulation of transcription, DNA-dependent [TASLink to PubMed articleLink to PubMed article]
    protein amino acid deacetylation [IDALink to PubMed articleLink to PubMed article]
    chromatin organization [TASLink to PubMed articleLink to PubMed article]
    Molecular Function: histone deacetylase activity [IDALink to PubMed article][IMPLink to PubMed article][TASLink to PubMed article]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MDSVMVKKEV LENPDHDLKR KLEENKEEEN SLSTTSKSKR QVIVPVCMPK IHYSPLKTGL  60
   61 CYDVRMRYHA KIFTSYFEYI DPHPEDPRRI YRIYKILAEN GLINDPTLSG VDDLGDLMLK 120
  121 IPVRAATSEE ILEVHTKEHL EFIESTEKMS REELLKETEK GDSVYFNNDS YASARLPCGG 180
  181 AIEACKAVVE GRVKNSLAVV RPPGHHAEPQ AAGGFCLFSN VAVAAKNILK NYPESVRRIM 240
  241 ILDWDIHHGN GTQKSFYQDD QVLYVSLHRF EMGKYYPGTI QGQYDQTGEG KGEGFNCNIT 300
  301 WPVGGVGDAE YMWAFEQVVM PMGREFKPDL VIISSGFDAA DGDTIGQCHV TPSCYGHMTH 360
  361 MLKSLARGNL CVVLEGGYNL DAIARSALSV AKVLIGEPPD ELPDPLSDPK PEVIEMIDKV 420
  421 IRLQSKYWNC FRRRHANSGC NFNEPINDSI ISKNFPLQKA IRQQQQHYLS DEFNFVTLPL 480
  481 VSMDLPDNTV LCTPNISESN TIIIVVHDTS DIWAKRNVIS GTIDLSSSVI IDNSLDFIKW 540
  541 GLDRKYGIID VNIPLTLFEP DNYSGMITSQ EVLIYLWDNY IKYFPSVAKI AFIGIGDSYS 600
  601 GIVHLLGHRD TRAVTKTVIN FLGDKQLKPL VPLVDETLSE WYFKNSLIFS NNSHQCWKEN 660
  661 ESRKPRKKFG RVLRCDTDGL NNIIEERFEE ATDFILDSFE EWSDEE

    Protein Complex Data

      PUBLICATION TOPOLOGY COCOMPLEXED PROTEINS
    View Details Riffle et al. (2010) (Unpublished Data) HDA1 HDA2 HDA3
    View Details Krogan NJ, et al. (2006) HDA1 HDA2 HDA3
    View Details Gavin AC, et al. (2006) HDA1 HDA2 HDA3 PRO2
    View Details Gavin AC, et al. (2002) ARX1 BEM2 BMS1 BRX1 BUD20 CIC1 CLU1 CMR1 CYR1 CYS4 DBP10 DBP9 DCP2 DNA2 DRS1 EBP2 ERB1 FPR4 GCN1 HAS1 HDA1 HDA2 HDA3 HER1 HIS3 HSC82 INP2 IPI1 IPI3 KAP95 KRE33 LCD1 LHP1 LOC1 LSG1 MAK21 MAK5 MDN1 MEC1 MGM101 MIS1 MLH1 MPH1 MRT4 MSH2 MSH3 MSH6 NAP1 NIP1 NIP7 NMD3 NOC2 NOC3 NOG1 NOG2 NOP1 NOP12 NOP15 NOP16 NOP2 NOP4 NOP56 NOP7 NSA1 NSA2 NUG1 OLA1 PGK1 PMS1 PRO2 PRT1 PUF6 RAD16 RAD52 REI1 RFA1 RFA2 RFA3 RIM1 RIX1 RIX7 RLP24 RLP7 RNH1 RPA135 RPA190 RPF1 RPF2 RPG1 RPP2B RPT6 RRP1 RRP12 RSA3 RSA4 RSC8 RTR1 RVB2 SDA1 SEC7 SGS1 SHS1 SKI2 SNU13 SPB1 SPB4 SSF1 TIF1, TIF2 TIF6 TOP3 TUB3 URB1 UTP10 UTP20 UTP22 VAS1 VPS1 YGL036W YHR122W YTM1
    View Details Qiu et al. (2008) HDA1 HDA2 HDA3 HOS1 HOS4 HST1 PHO23 RPD3 SAP30 SDS3 SET3 SIN3 SNT1

    Mass Spectrometry Data

    The following runs contain data for this protein:

      BAIT COMMENTS PUBLICATION
    View Run MLP2 #31 Asynchronous Prep (Protease cleavage) Keck JM, et al. (2011)

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    NOT SHOWING SINGLE HITS. [ Show Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

    No yeast two-hybrid interactions found for this protein.

    Microscopy / Localization Data

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      PROTEIN(S) PUBLICATION
    View Data HDA1 Huh WK, et al. (2003)

    Protein Structure Data


    [What does the above image mean?]
    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..236] PSI-BLAST 288.522879 HDAC homologue
    2 View Details [237..436] PSI-BLAST 288.522879 HDAC homologue
    3 View Details [437..706] deduced N/A No confident structure predictions are available.


    Reference: Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076


    Philius Transmembrane Prediction:

    Protein predicted to be: GLOBULAR (No transmembrane regions or signal peptide)
    Confidence of classification: 0.99

    Source: Reynolds et al. (2008)

    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle