Protein Overview: SLT2

General Information:
Name(s) found:	SLT2 / YHR030C [SGD]
Description(s) found: Found 25 descriptions. SHOW ALL	Serine/threonine MAP kinase involved in regulating the maintenance of cell wall integrity and progression through the cell cycle; regulated by the PKC1-mediated signaling pathway [SGD]
Organism:	Saccharomyces cerevisiae
Length:	484 amino acids
Gene Ontology:
Cellular Component:	nucleus [IDA][IGI] cellular bud tip [IDA] cytoplasm [IDA]
Biological Process:	response to acid [IMP] signal transduction [IMP] endoplasmic reticulum unfolded protein response [IDA][IMP] regulation of cell size [IMP] cellular cell wall organization [TAS] protein amino acid phosphorylation [ISS]
Molecular Function:	MAP kinase activity [ISS]

Sequence:

Sequence:
[PDR BLAST]
[ProtParam]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MADKIERHTF KVFNQDFSVD KRFQLIKEIG HGAYGIVCSA RFAEAAEDTT VAIKKVTNVF  60
   61 SKTLLCKRSL RELKLLRHFR GHKNITCLYD MDIVFYPDGS INGLYLYEEL MECDMHQIIK 120
  121 SGQPLTDAHY QSFTYQILCG LKYIHSADVL HRDLKPGNLL VNADCQLKIC DFGLARGYSE 180
  181 NPVENSQFLT EYVATRWYRA PEIMLSYQGY TKAIDVWSAG CILAEFLGGK PIFKGKDYVN 240
  241 QLNQILQVLG TPPDETLRRI GSKNVQDYIH QLGFIPKVPF VNLYPNANSQ ALDLLEQMLA 300
  301 FDPQKRITVD EALEHPYLSI WHDPADEPVC SEKFEFSFES VNDMEDLKQM VIQEVQDFRL 360
  361 FVRQPLLEEQ RQLQLQQQQQ QQQQQQQQQQ QPSDVDNGNA AASEENYPKQ MATSNSVAPQ 420
  421 QESFGIHSQN LPRHDADFPP RPQESMMEMR PATGNTADIP PQNDNGTLLD LEKELEFGLD 480
  481 RKYF

Protein Complex Data

	PUBLICATION	TOPOLOGY	COCOMPLEXED PROTEINS
View Details	Ho Y, et al. (2002)		AHA1 ARP2 BCK1 BMS1 BUD7 CDC53 CIC1 COF1 COR1 CPR6 CTF4 DBP10 DED81 DIA2 EGD2 ENP1 FOL2 FPR3 FUS3 GAL7 GND1 IDH1 ILS1 ILV5 IPP1 KIC1 KIN2 KRE33 KRI1 LHS1 LST4 LYS12 MCM2 MCM3 MCM5 MKK2 MKT1 MSG5 NIP7 NMD3 NOP12 OYE2 PDC6 PIL1 PMA1 PRE3 QCR2 RCN2 RPN6 RPT3 RRP12 SDP1 SEH1 SIS1 SKG3 SKP1 SLT2 SMK1 SPB1 SRV2 SSF1 SSF2 SSZ1 STI1 TAL1 TIF1, TIF2 TIF6 URB1 UTP10 YAK1 YBL104C

Mass Spectrometry Data

The following runs contain data for this protein:

	BAIT	COMMENTS	PUBLICATION
View Run	VAM3	Sample: HX14 - mixture in detergent (control).	Hao Xu, et al. (2010)

Yeast Two-Hybrid Data

The following interactions contain this protein:

SHOWING SINGLE HITS. [ Hide Single Hits ]

[View our yeast two-hybrid interpretation guidelines.]

	BAIT	PREY	HITS	PUBLICATION
View Screen	SDP1	SLT2	2	Uetz P, et al. (2000)
View Screen	ATG12	SLT2	1	Unpublished Fields Lab Data
View Screen	YDR131C	SLT2	1	Unpublished Fields Lab Data
View Screen	PRP42	SLT2	1	Unpublished Fields Lab Data
View Screen	RPT3	SLT2	1	Unpublished Fields Lab Data
View Screen	SPT23	SLT2	1	Unpublished Fields Lab Data
View Screen	TEM1	SLT2	1	Unpublished Fields Lab Data
View Screen	PAU21, PAU22	SLT2	1	Unpublished Fields Lab Data

Microscopy / Localization Data

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	PROTEIN(S)	PUBLICATION
View Data	SLT2	Huh WK, et al. (2003)

Protein Structure Data

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[View Top Sequence Alignments] [Show Ginzu Version Information]

Domains predicted:

#		Region(s)	Method	Confidence	Match Description
1	View Details	[1..75] [88..110] [338..411]	PSI-BLAST	1008.54902	MAP kinase Erk2
2	View Details	[76..87] [111..337]	PSI-BLAST	1008.54902	MAP kinase Erk2
3	View Details	[412..484]	deduced	N/A	No confident structure predictions are available.

Functions predicted (by domain):

Gene Ontology predictions

Term	Confidence	Notes
acetylcholine receptor activator activity	5.9159846946654	bayes_pls_golite062009
general RNA polymerase II transcription factor activity	5.68265749805481	bayes_pls_golite062009
phosphotransferase activity, alcohol group as acceptor	5.49988294224815	bayes_pls_golite062009
protein kinase activity	5.4586557943719	bayes_pls_golite062009
kinase activity	5.3287080791198	bayes_pls_golite062009
transferase activity, transferring phosphorus-containing groups	4.96052051118534	bayes_pls_golite062009
cyclin-dependent protein kinase activity	4.62392503670521	bayes_pls_golite062009
protein serine/threonine kinase activity	4.46381887831481	bayes_pls_golite062009
transferase activity	3.97138602499442	bayes_pls_golite062009
structural molecule activity	3.82327979736517	bayes_pls_golite062009
transmembrane receptor protein tyrosine kinase activity	3.41480681854114	bayes_pls_golite062009
transmembrane receptor protein kinase activity	3.40140621607334	bayes_pls_golite062009
MAP kinase 2 activity	3.27009208121248	bayes_pls_golite062009
protein tyrosine kinase activity	2.8153155526437	bayes_pls_golite062009
phosphoinositide 3-kinase binding	2.79505438761262	bayes_pls_golite062009
binding	2.74863538127007	bayes_pls_golite062009
transmembrane receptor activity	2.59526003830791	bayes_pls_golite062009
ion transmembrane transporter activity	2.52531786618214	bayes_pls_golite062009
RNA binding	2.47233810641059	bayes_pls_golite062009
cation transmembrane transporter activity	2.46424348876434	bayes_pls_golite062009
signal transducer activity	2.40586892801446	bayes_pls_golite062009
molecular transducer activity	2.40586892801446	bayes_pls_golite062009
receptor activity	2.39311927684508	bayes_pls_golite062009
substrate-specific transmembrane transporter activity	2.37122853419919	bayes_pls_golite062009
transmembrane receptor protein serine/threonine kinase activity	2.30873410607588	bayes_pls_golite062009
transforming growth factor beta receptor activity	2.30873410607588	bayes_pls_golite062009
histone kinase activity (H3-S10 specific)	2.30449166929476	bayes_pls_golite062009
protein binding	2.276111749106	bayes_pls_golite062009
tubulin binding	2.18641675163967	bayes_pls_golite062009
cytoskeletal protein binding	2.12615078788254	bayes_pls_golite062009
receptor signaling protein activity	2.10379226653669	bayes_pls_golite062009
ATP binding	1.97600611746091	bayes_pls_golite062009
ubiquitin-protein ligase activity	1.94085498993561	bayes_pls_golite062009
adenyl ribonucleotide binding	1.93596671856664	bayes_pls_golite062009
adenyl nucleotide binding	1.90928021591891	bayes_pls_golite062009
metal ion transmembrane transporter activity	1.9016235206634	bayes_pls_golite062009
microtubule binding	1.88110801192607	bayes_pls_golite062009
actin binding	1.87817875565699	bayes_pls_golite062009
receptor signaling protein serine/threonine kinase activity	1.81249386965144	bayes_pls_golite062009
telethonin binding	1.75733591474207	bayes_pls_golite062009
transforming growth factor beta receptor activity, type I	1.74645334586495	bayes_pls_golite062009
small conjugating protein ligase activity	1.74206248731815	bayes_pls_golite062009
activin binding	1.69795678545106	bayes_pls_golite062009
fibroblast growth factor 1 binding	1.66976264488423	bayes_pls_golite062009
purine ribonucleotide binding	1.65732943334212	bayes_pls_golite062009
ribonucleotide binding	1.65726906484847	bayes_pls_golite062009
activin receptor activity	1.64506335968643	bayes_pls_golite062009
purine nucleotide binding	1.63763394711025	bayes_pls_golite062009
nucleotide binding	1.63195828048121	bayes_pls_golite062009
insulin receptor substrate binding	1.62657794525303	bayes_pls_golite062009
JUN kinase kinase kinase activity	1.60259443694567	bayes_pls_golite062009
transcription regulator activity	1.56748951434625	bayes_pls_golite062009
growth factor binding	1.53863828216563	bayes_pls_golite062009
nucleic acid binding	1.46547714006072	bayes_pls_golite062009
MAP kinase kinase activity	1.42275431028856	bayes_pls_golite062009
DNA binding	1.35333135345112	bayes_pls_golite062009
ErbB-3 class receptor binding	1.34841233233438	bayes_pls_golite062009
ErbB-2 class receptor binding	1.33825339298024	bayes_pls_golite062009
kinase binding	1.26086833316556	bayes_pls_golite062009
acid-amino acid ligase activity	1.2266791546014	bayes_pls_golite062009
catalytic activity	1.21655087018101	bayes_pls_golite062009
transcription elongation regulator activity	1.16995153203536	bayes_pls_golite062009
transcription repressor activity	1.14496167267281	bayes_pls_golite062009
transporter activity	1.11833481501707	bayes_pls_golite062009
non-membrane spanning protein tyrosine kinase activity	1.11664317075762	bayes_pls_golite062009
transcription factor activity	1.10928254946881	bayes_pls_golite062009
protein kinase binding	1.06030596516506	bayes_pls_golite062009
cation channel activity	1.04999722123563	bayes_pls_golite062009
type II transforming growth factor beta receptor binding	1.03605423743048	bayes_pls_golite062009
SMAD binding	1.02108562119195	bayes_pls_golite062009
transcription activator activity	0.997272622653026	bayes_pls_golite062009
PTB domain binding	0.9900774724568	bayes_pls_golite062009
transmembrane transporter activity	0.97575992765505	bayes_pls_golite062009
alpha-actinin binding	0.877087652539674	bayes_pls_golite062009
insulin-like growth factor receptor binding	0.872782211382796	bayes_pls_golite062009
fibroblast growth factor binding	0.870666814073948	bayes_pls_golite062009
activin receptor activity, type I	0.82317428935631	bayes_pls_golite062009
MAP kinase activity	0.81943579965027	bayes_pls_golite062009
actin filament binding	0.794152600084	bayes_pls_golite062009
fibroblast growth factor receptor activity	0.75189004129952	bayes_pls_golite062009
receptor serine/threonine kinase binding	0.728917900114111	bayes_pls_golite062009
substrate-specific transporter activity	0.705905455086486	bayes_pls_golite062009
transforming growth factor beta receptor binding	0.705634826374884	bayes_pls_golite062009
transmembrane receptor protein serine/threonine kinase binding	0.705634826374884	bayes_pls_golite062009
hormone receptor binding	0.705067960165986	bayes_pls_golite062009
beta-catenin binding	0.693246095477001	bayes_pls_golite062009
structural constituent of cytoskeleton	0.612883428421652	bayes_pls_golite062009
JUN kinase kinase kinase kinase activity	0.546647574638943	bayes_pls_golite062009
cyclin-dependent protein kinase activating kinase activity	0.529121666062889	bayes_pls_golite062009
steroid hormone receptor binding	0.505233004492768	bayes_pls_golite062009
protein serine/threonine/tyrosine kinase activity	0.48345772948903	bayes_pls_golite062009
enzyme binding	0.46284745266176	bayes_pls_golite062009
transforming growth factor beta binding	0.435457844706269	bayes_pls_golite062009
protein kinase C activity	0.41587987561486	bayes_pls_golite062009
cyclin-dependent protein kinase regulator activity	0.406297251827056	bayes_pls_golite062009
RNA polymerase II transcription factor activity	0.401250804041384	bayes_pls_golite062009
structural constituent of muscle	0.399773397398032	bayes_pls_golite062009
magnesium ion binding	0.393328812780268	bayes_pls_golite062009
MAP kinase kinase kinase activity	0.37115026509016	bayes_pls_golite062009
JUN kinase kinase activity	0.332372116912461	bayes_pls_golite062009
structure-specific DNA binding	0.318153468064373	bayes_pls_golite062009
channel activity	0.287189255116606	bayes_pls_golite062009
passive transmembrane transporter activity	0.287189255116606	bayes_pls_golite062009
insulin receptor binding	0.266450215230107	bayes_pls_golite062009
substrate-specific channel activity	0.261869836686301	bayes_pls_golite062009
ion channel activity	0.241519346930618	bayes_pls_golite062009
nuclear hormone receptor binding	0.240883589532225	bayes_pls_golite062009
protein complex binding	0.239339759110451	bayes_pls_golite062009
insulin receptor activity	0.237134032032089	bayes_pls_golite062009
SH2 domain binding	0.226760162354251	bayes_pls_golite062009
ligase activity, forming carbon-oxygen bonds	0.149958560815481	bayes_pls_golite062009
ligase activity, forming aminoacyl-tRNA and related compounds	0.149958560815481	bayes_pls_golite062009
aminoacyl-tRNA ligase activity	0.14842991990838	bayes_pls_golite062009
peptide binding	0.118578378753757	bayes_pls_golite062009
brain-derived neurotrophic factor binding	0.0794053647730006	bayes_pls_golite062009
nitric-oxide synthase regulator activity	0.00407218246327123	bayes_pls_golite062009
nucleoside-triphosphatase activity	0.0040394359628233	bayes_pls_golite062009

No functions predicted.

Reference: Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076

Philius Transmembrane Prediction:

Protein predicted to be:	GLOBULAR (No transmembrane regions or signal peptide)
Confidence of classification:	0.99

Source: Reynolds et al. (2008)

TMHMM	2.0c	PSIPRED	v2.61
SignalP	3.0	COILS	1999
DISOPRED	v0.1	NCBI nr	06/2007
PSI-BLAST	2.2.18	FFAS	ffas03
PDB	06/2007	Pfam	22
HMMER	2.3.2