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Protein Overview: PGM2

General Information:
Name(s) found: PGM2 / YMR105C [SGD]
Description(s) found:
Found 30 descriptions.
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  • Phosphoglucomutase, catalyzes the conversion from glucose-1-phosphate to glucose-6-phosphate, which is a key step in hexose metabolism; functions as the acceptor for a Glc-phosphotransferase [SGD]
    • Organism: Saccharomyces cerevisiae
    Length: 569 amino acids

    Gene Ontology:
    Cellular Component: cytosol [TAS]
    Biological Process: response to temperature stimulus [RCA]
    energy reserve metabolic process [RCA]
    UDP-glucose metabolic process [IGI]
    trehalose biosynthetic process [IGI]
    alcohol metabolic process [RCA]
    glucose metabolic process [IEA]
    cellular calcium ion homeostasis [IGI][IMP]
    vacuolar protein catabolic process [RCA]
    carbohydrate metabolic process [IEA]
    glycogen biosynthetic process [IGI]
    glucose 6-phosphate metabolic process [ISS]
    cellular carbohydrate metabolic process [RCA]
    galactose catabolic process [IGI][IMP]
    glucose 1-phosphate metabolic process [IGI][IMP][ISS]
    cellular cation homeostasis [IMP]
    Molecular Function: phosphoglucomutase activity [IMPLink to PubMed article][ISSLink to PubMed article]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MSFQIETVPT KPYEDQKPGT SGLRKKTKVF KDEPNYTENF IQSIMEAIPE GSKGATLVVG  60
   61 GDGRYYNDVI LHKIAAIGAA NGIKKLVIGQ HGLLSTPAAS HIMRTYEEKC TGGIILTASH 120
  121 NPGGPENDMG IKYNLSNGGP APESVTNAIW EISKKLTSYK IIKDFPELDL GTIGKNKKYG 180
  181 PLLVDIIDIT KDYVNFLKEI FDFDLIKKFI DNQRSTKNWK LLFDSMNGVT GPYGKAIFVD 240
  241 EFGLPADEVL QNWHPSPDFG GMHPDPNLTY ASSLVKRVDR EKIEFGAASD GDGDRNMIYG 300
  301 YGPSFVSPGD SVAIIAEYAA EIPYFAKQGI YGLARSFPTS GAIDRVAKAH GLNCYEVPTG 360
  361 WKFFCALFDA KKLSICGEES FGTGSNHVRE KDGVWAIMAW LNILAIYNKH HPENEASIKT 420
  421 IQNEFWAKYG RTFFTRYDFE KVETEKANKI VDQLRAYVTK SGVVNSAFPA DESLKVTDCG 480
  481 DFSYTDLDGS VSDHQGLYVK LSNGARFVLR LSGTGSSGAT IRLYIEKYCD DKSQYQKTAE 540
  541 EYLKPIINSV IKFLNFKQVL GTEEPTVRT

    Protein Complex Data

      PUBLICATION TOPOLOGY COCOMPLEXED PROTEINS
    View Details Krogan NJ, et al. (2006) PGM2 PTC5
    View Details Ho Y, et al. (2002) AAC3 ABP1 ACH1 ACS2 ADE17 ADE3 ADE5,7 ADE6 ADH4 ADO1 AGX1 AHA1 ALA1 APE2 APP1 ARA1 ARO1 ARP10 BAT1 BUD13 CAR2 CDC10 CDC15 CDC28 CDC33 CDC53 CKS1 CLN1 CLU1 CMD1 CMK2 CMP2 COF1 CPA2 CPR1 CYS3 CYS4 DBP8 DED81 DIP2 DIP5 DPS1 DUN1 EDE1 ENP1 ERG10 ERG20 FET4 FYV8 GCY1 GPH1 GRS1 GSP1 GSP2 HCH1 HEF3 HOM2 HOM3 HOR2 HRP1 HXT7 HYP2 ILS1 IMD3 INM1 IPP1 IST3 KAP104 KGD1 KRS1 LSP1 MAM33 MDH1 MDH3 MRT4 MTC5 MUM2 MYO2 MYO4 MYO5 NAB2 NTG1 OLA1 OPY1 OYE2 PAB1 PDX3 PFK1 PFK2 PGM1 PGM2 PMI40 POR1 PRB1 PRP6 PST2 RAD59 RFA3 RFC2 RHR2 RNR1 RNR2 RPB3 RPN1 RPT3 SAC6 SAH1 SCP160 SEC26 SEC27 SEC53 SHE3 SOD1 SRP1 SRV2 SSZ1 STE4 STI1 TFP1 THI22 THR4 TIF1, TIF2 TMA29 TPS1 TRR1 UBA1 UTP13 UTP18 VAS1 VMA4 VPS13 YDL063C YDL086W YDL124W YDR306C YDR341C YHR020W YJR141W YNK1 YNL035C YPR015C YRB1
    View Details Qiu et al. (2008) GLK1 GPM1 PGM1 PGM2

    Mass Spectrometry Data

    No mass spectrometry results found for this protein.

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    SHOWING SINGLE HITS. [ Hide Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

      BAIT PREY HITS PUBLICATION
    View Screen YIF1 PGM2 1 Unpublished Fields Lab Data
    View Screen CIT2 PGM2 1 Unpublished Fields Lab Data

    Microscopy / Localization Data

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      PROTEIN(S) PUBLICATION
    View Data PGM2 Huh WK, et al. (2003)

    Protein Structure Data


    [What does the above image mean?]
    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..191] PSI-BLAST 1736.0 Phosphoglucomutase
    2 View Details [192..305]
    [386..420]    		 PSI-BLAST 1736.0 Phosphoglucomutase
    3 View Details [306..385]
    [421..431]
    [483..493]    		 PSI-BLAST 1736.0 Phosphoglucomutase
    4 View Details [432..482]
    [494..569]    		 PSI-BLAST 1736.0 Phosphoglucomutase

    Functions predicted (by domain):

    # Gene Ontology predictions
    1
    Term Confidence Notes
  • phosphoglucomutase activity
    		•  3.58264389178108 bayes_pls_golite062009
  • binding
    		•  1.81828980398861 bayes_pls_golite062009
  • structural molecule activity
    		•  1.71130645303643 bayes_pls_golite062009
  • intramolecular transferase activity, phosphotransferases
    		•  0.9938893438261 bayes_pls_golite062009
  • phosphomannomutase activity
    		•  0.96914970670646 bayes_pls_golite062009
  • catalytic activity
    		•  0.792640318995558 bayes_pls_golite062009
  • protein binding
    		•  0.359358565373414 bayes_pls_golite062009
  • isomerase activity
    		•  0.340395019264179 bayes_pls_golite062009
    2 No functions predicted.
    3 No functions predicted.
    4 No functions predicted.


    Reference: Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076


    Philius Transmembrane Prediction:

    Protein predicted to be: GLOBULAR (No transmembrane regions or signal peptide)
    Confidence of classification: 0.99

    Source: Reynolds et al. (2008)

    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle