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Protein Overview: UBA1

General Information:
Name(s) found: UBA1 / YKL210W [SGD]
Description(s) found:
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  • gi|6322639|ref|NP_012712.1| Ubiquitin activating enzyme (E1), involved in ubiquitin-mediated protein degradation and essential for viability; Uba1p [Saccharomyces cerevisiae] [NCBI NR]
  • gi|549145|sp|P22515.2|UBA1_YEAST RecName: Full=Ubiquitin-activating enzyme E1 1 [NCBI NR]
  • pir||S38048 ubiquitin-protein ligase (EC 6.3.2.19) - yeast (Saccharomyces cerevisiae) [NCBI NR]
  • gi|486375|emb|CAA82055.1| UBA1 [Saccharomyces cerevisiae] [NCBI NR]
  • Ubiquitin-activating enzyme E1 1 OS=Saccharomyces cerevisiae GN=UBA1 PE=1 SV=2 [Swiss-Prot]
  • UBA1 E1-like (ubiquitin-activating) enzyme [mips]
  • Ubiquitin activating enzyme (E1), involved in ubiquitin-mediated protein degradation and essential for viability [SGD]
  • UBA1, Chr XI from 39164-42238 [yeast_orfs2]
  • Chr XI from 39164-42238 [yeastorf3.fasta]
  • (P22515) Ubiquitin-activating enzyme E1 1 [4932.FASTACCERV.txt]
  • UBA1 SGDID:S0001693, Chr XI from 39164-42238, Verified ORF [yeastflysequest.fasta]
  • Uba1p [Saccharomyces cerevisiae]gi|486375|emb|CAA82055.1| UBA1 [Saccharomyces cerevisiae]gi|538616|pir||S38048 ubiquitin-protein ligase (EC 6.3.2.19) - yeast (Saccharomyces cerevisiae)gi|549145|sp|P22515|UBA1_YEAST Ubiquitin-activating enzyme E1 1 [nrdb_11152004_Chlamydomonas]
  • UBA1 SGDID:S000001693, Chr XI from 39164-42238, Verified ORF, "Ubiquitin activating enzyme, involved in ubiquitin-mediated protein degradation and essential for viability" [SGD_S-cerevisiae_na_12-16-2005_con_reversed.fasta]
  • UBA1 SGDID:S000001693, Chr XI from 39164-42238, Verified ORF, "Ubiquitin activating enzyme (E1), involved in ubiquitin-mediated protein degradation and essential for viability" [SGD_S-cerevisiae_na_08-19-2008_con_reversed.fasta]
  • UBA1 [Saccharomyces cerevisiae] [nr-271106-contam.fasta]
  • Ubiquitin activating enzyme, involved in ubiquitin-mediated protein degradation and essential for viability; Uba1p [Saccharomyces cerevisiae] [nr-271106-contam.fasta]
  • Ubiquitin-activating enzyme E1 1 [nr-271106-contam.fasta]
  • [chemostatdb.fasta]
  • Ubiquitin-activating enzyme E1 1 OS=Saccharomyces cerevisiae (strain ATCC 204508 / S288c) GN=UBA1 PE=1 SV=2 [UniProt_S_cerevisiae_20120516_05-16-2012_reversed.fasta]
  • UBA1 SGDID:S000001693, Chr XI from 39163-42237, Genome Release 64-1-1, Verified ORF, "Ubiquitin activating enzyme (E1), involved in ubiquitin-mediated protein degradation and essential for viability" [yeast-030211-contam.fasta]
  • UBA1 SGDID:S000001693, Chr XI from 39163-42237, Genome Release 64-2-1, Verified ORF, "Ubiquitin activating enzyme (E1); involved in ubiquitin-mediated protein degradation and essential for viability; protein abundance increases in response to DNA replication stress" [20141208_orf_trans.fasta]
  • YKL210W SGDID:S000001693, Chr XI from 39163-42237, Genome Release 64-1-1, Verified ORF, "Ubiquitin activating enzyme (E1), involved in ubiquitin-mediated protein degradation and essential for viability" [2016-01-SGD_Yeast_Contam_Riffle_20140507-Ska-Hec-110-tubulin.fasta]
    • Organism: Saccharomyces cerevisiae
    Length: 1024 amino acids

    Gene Ontology:
    Cellular Component: nucleus [IDALink to PubMed article]
    cytoplasm [IDALink to PubMed article]
    Biological Process: ubiquitin cycle [TASLink to PubMed article]
    Molecular Function: ubiquitin activating enzyme activity [TASLink to PubMed article]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MSSNNSGLSA AGEIDESLYS RQLYVLGKEA MLKMQTSNVL ILGLKGLGVE IAKNVVLAGV  60
   61 KSMTVFDPEP VQLADLSTQF FLTEKDIGQK RGDVTRAKLA ELNAYVPVNV LDSLDDVTQL 120
  121 SQFQVVVATD TVSLEDKVKI NEFCHSSGIR FISSETRGLF GNTFVDLGDE FTVLDPTGEE 180
  181 PRTGMVSDIE PDGTVTMLDD NRHGLEDGNF VRFSEVEGLD KLNDGTLFKV EVLGPFAFRI 240
  241 GSVKEYGEYK KGGIFTEVKV PRKISFKSLK QQLSNPEFVF SDFAKFDRAA QLHLGFQALH 300
  301 QFAVRHNGEL PRTMNDEDAN ELIKLVTDLS VQQPEVLGEG VDVNEDLIKE LSYQARGDIP 360
  361 GVVAFFGGLV AQEVLKACSG KFTPLKQFMY FDSLESLPDP KNFPRNEKTT QPVNSRYDNQ 420
  421 IAVFGLDFQK KIANSKVFLV GSGAIGCEML KNWALLGLGS GSDGYIVVTD NDSIEKSNLN 480
  481 RQFLFRPKDV GKNKSEVAAE AVCAMNPDLK GKINAKIDKV GPETEEIFND SFWESLDFVT 540
  541 NALDNVDART YVDRRCVFYR KPLLESGTLG TKGNTQVIIP RLTESYSSSR DPPEKSIPLC 600
  601 TLRSFPNKID HTIAWAKSLF QGYFTDSAEN VNMYLTQPNF VEQTLKQSGD VKGVLESISD 660
  661 SLSSKPHNFE DCIKWARLEF EKKFNHDIKQ LLFNFPKDAK TSNGEPFWSG AKRAPTPLEF 720
  721 DIYNNDHFHF VVAGASLRAY NYGIKSDDSN SKPNVDEYKS VIDHMIIPEF TPNANLKIQV 780
  781 NDDDPDPNAN AANGSDEIDQ LVSSLPDPST LAGFKLEPVD FEKDDDTNHH IEFITACSNC 840
  841 RAQNYFIETA DRQKTKFIAG RIIPAIATTT SLVTGLVNLE LYKLIDNKTD IEQYKNGFVN 900
  901 LALPFFGFSE PIASPKGEYN NKKYDKIWDR FDIKGDIKLS DLIEHFEKDE GLEITMLSYG 960
  961 VSLLYASFFP PKKLKERLNL PITQLVKLVT KKDIPAHVST MILEICADDK EGEDVEVPFI1020
 1021 TIHL

    Protein Complex Data

      PUBLICATION TOPOLOGY COCOMPLEXED PROTEINS
    View Details Riffle et al. (2010) (Unpublished Data) UBA1 YDR415C
    View Details Krogan NJ, et al. (2006) CYS3 IPL1 RAX2 SER1 UBA1 YDR415C YER156C
    View Details Ho Y, et al. (2002) AAC3 AAT2 ACH1 ACO1 ACS2 ADE3 ADE6 ADO1 AFR1 AHA1 AHP1 ALA1 APE2 ARA1 ARC1 ARF1 ARO9 ATP3 ATP4 BAT1 BEM2 BUD14 CAR2 CDC10 CDC33 CLU1 CMD1 CMK2 CMP2 COF1 COR1 CPR1 CTK3 CYR1 CYS3 CYS4 DED81 DOG1 DPS1 ECM10 EDE1 EGD1 ERG10 ERG13 ERG20 ERG6 FOL2 FPR1 FRS2 GCD11 GCN1 GCY1 GIS4 GND1 GND2 GPH1 GRS1 GRX1 GUS1 HCH1 HEF3 HHF1, HHF2 HOM2 HOM3 HOR2 HSP104 HYP2 ILS1 ILV2 IMD3 IPP1 KEL1 KEL2 KIN2 KRE6 KRS1 LOS1 LRO1 LSP1 MDH3 MET6 MMS2 MYO2 MYO4 MYO5 NTF2 OLA1 OYE2 PAB1 PFK1 PFK2 PGM2 PIL1 PMI40 POL5 POP2 PRB1 PRM2 PRP6 PST2 PTC3 RAD18 RAD52 RAD59 RAD6 REX2 RHR2 RNR2 RSN1 RVB1 SAC6 SAH1 SCP160 SEC27 SEC53 SEC7 SEN15 SER1 SES1 SHE3 SNU13 SOD1 SSZ1 STB3 STI1 TEF4 TFC4 THR4 THS1 TIF1, TIF2 TMA19 TRR1 TSA2 UBA1 UBC13 UBC6 UTP20 VAS1 VMA4 VMA5 VMA8 VPS13 WTM1 YCK1 YDL124W YER138C YNK1 YPT1 YPT31

    Mass Spectrometry Data

    The following runs contain data for this protein:

      BAIT COMMENTS PUBLICATION
    View Run CAB4 No Comments Hazbun TR, et al. (2003)
    View Run RBA50 No Comments Hazbun TR, et al. (2003)
    View Run MLP2 #25 Asynchronous Prep3-TiO2 Flowthrough Keck JM, et al. (2011)
    View Run MLP2 #34 Asynchronous SPB prep Keck JM, et al. (2011)
    View Run MLP2 #12 Mitotic Prep1-TiO2 Flowthrough Keck JM, et al. (2011)

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    NOT SHOWING SINGLE HITS. [ Show Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

    No yeast two-hybrid interactions found for this protein.

    Microscopy / Localization Data

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      PROTEIN(S) PUBLICATION
    View Data UBA1 Huh WK, et al. (2003)

    Protein Structure Data


    [What does the above image mean?]
    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..306] PSI-BLAST 176.529817 Molybdenum cofactor biosynthesis protein MoeB
    2 View Details [307..408] deduced N/A No confident structure predictions are available.
    3 View Details [409..620] ORFEUS 7.43 ADP-L-glycero-D-mannoheptose 6-epimerase
    4 View Details [621..750] MSA 2.071965 View MSA. No confident structure predictions are available.
    5 View Details [751..813] deduced N/A No confident structure predictions are available.
    6 View Details [814..1024] MSA 4.038957 View MSA. No confident structure predictions are available.


    Reference: Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076


    Philius Transmembrane Prediction:

    Protein predicted to be: GLOBULAR (No transmembrane regions or signal peptide)
    Confidence of classification: 0.94

    Source: Reynolds et al. (2008)

    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle