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Protein Overview: MMS2

General Information:
Name(s) found: MMS2 / YGL087C [SGD]
Description(s) found:
Found 32 descriptions.
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  • Ubiquitin-conjugating enzyme variant involved in error-free postreplication repair; forms a heteromeric complex with Ubc13p, an active ubiquitin-conjugating enzyme; cooperates with chromatin-associated RING finger proteins, Rad18p and Rad5p [SGD]
    • Organism: Saccharomyces cerevisiae
    Length: 137 amino acids

    Gene Ontology:
    Cellular Component: nucleus [IDALink to PubMed article]
    cytoplasm [IDALink to PubMed article]
    ubiquitin conjugating enzyme complex [IPILink to PubMed article]
    Biological Process: protein polyubiquitination [IDALink to PubMed article][IPILink to PubMed article]
    response to DNA damage stimulus [IMPLink to PubMed article]
    postreplication repair [IGILink to PubMed articleLink to PubMed article][IMPLink to PubMed articleLink to PubMed article]
    Molecular Function: ubiquitin-protein ligase activity [IDALink to PubMed article][ISSLink to PubMed articleLink to PubMed article]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MSKVPRNFRL LEELEKGEKG FGPESCSYGL ADSDDITMTK WNGTILGPPH SNHENRIYSL  60
   61 SIDCGPNYPD SPPKVTFISK INLPCVNPTT GEVQTDFHTL RDWKRAYTME TLLLDLRKEM 120
  121 ATPANKKLRQ PKEGETF

    Protein Complex Data

      PUBLICATION TOPOLOGY COCOMPLEXED PROTEINS
    View Details Riffle et al. (2010) (Unpublished Data) MMS2 SIP5 UBC13
    View Details Krogan NJ, et al. (2006) MMS2 SIP5 UBC13
    View Details Ho Y, et al. (2002) ARO9 IRA2 MMS2 RAD18 RCN2 REX2 RSP5 UBA1 UBC13
    View Details Qiu et al. (2008) MMS2 UBC13

    Mass Spectrometry Data

    No mass spectrometry results found for this protein.

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    NOT SHOWING SINGLE HITS. [ Show Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

    No yeast two-hybrid interactions found for this protein.

    Microscopy / Localization Data

    New Feature: Upload Your Own Microscopy Data

      PROTEIN(S) PUBLICATION
    View Data MMS2 Huh WK, et al. (2003)

    Protein Structure Data


    [What does the above image mean?]
    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..137] PSI-BLAST 785.529817 Ubiquitin conjugating enzyme, UBC

    Functions predicted (by domain):

    # Gene Ontology predictions
    1
    Term Confidence Notes
  • ubiquitin-protein ligase activity
    		•  7.07009148420636 bayes_pls_golite062009
  • small conjugating protein ligase activity
    		•  7.03976510657099 bayes_pls_golite062009
  • acid-amino acid ligase activity
    		•  6.00007452476109 bayes_pls_golite062009
  • ligase activity, forming carbon-nitrogen bonds
    		•  5.06177413452771 bayes_pls_golite062009
  • transcription regulator activity
    		•  1.9559492182519 bayes_pls_golite062009
  • ligase activity
    		•  1.88059319399119 bayes_pls_golite062009
  • nucleic acid binding
    		•  1.83472092683523 bayes_pls_golite062009
  • DNA binding
    		•  1.77393825735008 bayes_pls_golite062009
  • binding
    		•  1.75350658654805 bayes_pls_golite062009
  • catalytic activity
    		•  0.891402822028799 bayes_pls_golite062009
  • SUMO ligase activity
    		•  0.843488104298821 bayes_pls_golite062009
  • protein binding
    		•  0.726328463755484 bayes_pls_golite062009
  • NEDD8 ligase activity
    		•  0.715654744941217 bayes_pls_golite062009
  • phosphotransferase activity, alcohol group as acceptor
    		•  0.58835335751383 bayes_pls_golite062009
  • kinase activity
    		•  0.519703305315987 bayes_pls_golite062009
  • protein kinase activity
    		•  0.443948654247666 bayes_pls_golite062009
  • transferase activity, transferring phosphorus-containing groups
    		•  0.373779304908933 bayes_pls_golite062009
  • protein serine/threonine kinase activity
    		•  0.182854082413338 bayes_pls_golite062009
  • transferase activity
    		•  0.0984525836903841 bayes_pls_golite062009


    Reference: Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076


    Philius Transmembrane Prediction:

    Protein predicted to be: GLOBULAR (No transmembrane regions or signal peptide)
    Confidence of classification: 0.99

    Source: Reynolds et al. (2008)

    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle