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Protein Overview: RTG2

General Information:
Name(s) found: RTG2 / YGL252C [SGD]
Description(s) found:
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  • gi|6321185|ref|NP_011262.1| Sensor of mitochondrial dysfunction; regulates the subcellular location of Rtg1p and Rtg3p, transcriptional activators of the retrograde (RTG) and TOR pathways; Rtg2p is inhibited by the phosphorylated form of Mks1p; Rtg2p [Sac [NCBI NR]
  • gi|51013069|gb|AAT92828.1| YGL252C [Saccharomyces cerevisiae] [NCBI NR]
  • pir||S61609 RTG2 protein - yeast (Saccharomyces cerevisiae) [NCBI NR]
  • gi|1710803|sp|P32608.2|RTG2_YEAST RecName: Full=Retrograde regulation protein 2 [NCBI NR]
  • gi|1322929|emb|CAA96972.1| RTG2 [Saccharomyces cerevisiae] [NCBI NR]
  • gi|1262162|gb|AAA96809.1| Rtg2p [Saccharomyces cerevisiae] [NCBI NR]
  • gi|1150587|emb|CAA64135.1| RTG2 [Saccharomyces cerevisiae] [NCBI NR]
  • Retrograde regulation protein 2 OS=Saccharomyces cerevisiae GN=RTG2 PE=1 SV=2 [Swiss-Prot]
  • RTG2 Retrograde regulation protein [mips]
  • Sensor of mitochondrial dysfunction; regulates the subcellular location of Rtg1p and Rtg3p, transcriptional activators of the retrograde (RTG) and TOR pathways; Rtg2p is inhibited by the phosphorylated form of Mks1p [SGD]
  • RTG2, Chr VII from 25718-27484, reverse complement [yeast_orfs2]
  • Chr VII from 25718-27484, reverse complement [yeastorf3.fasta]
  • Chr VII from 27484-25718, reverse complement [yeastorf5.fasta]
  • (P32608) Retrograde regulation protein 2 [4932.FASTACCERV.txt]
  • RTG2 SGDID:S0003221, Chr VII from 27484-25718, reverse complement, Verified ORF [yeastflysequest.fasta]
  • Rtg2p [Saccharomyces cerevisiae]gi|51013069|gb|AAT92828.1| YGL252C [Saccharomyces cerevisiae]gi|1322929|emb|CAA96972.1| RTG2 [Saccharomyces cerevisiae]gi|1150587|emb|CAA64135.1| RTG2 [Saccharomyces cerevisiae]gi|1710803|sp|P32608|RTG2_YEAST Retrograde [nrdb_11152004_Chlamydomonas]
  • RTG2 SGDID:S000003221, Chr VII from 27484-25718, reverse complement, Verified ORF, "Sensor of mitochondrial dysfunction; regulates the subcellular location of Rtg1p and Rtg3p, transcriptional activators of the retrograde (RTG) and TOR pathways; Rtg2p is i [SGD_S-cerevisiae_na_12-16-2005_con_reversed.fasta]
  • Sensor of mitochondrial dysfunction; regulates the subcellular location of Rtg1p and Rtg3p, transcriptional activators of the retrograde (RTG) and TOR pathways; Rtg2p is inhibited by the phosphorylated form of Mks1p; Rtg2p [Saccharomyces cerevisiae] [nr-271106-contam.fasta]
  • Rtg2p [nr-271106-contam.fasta]
  • RTG2 [Saccharomyces cerevisiae] [nr-271106-contam.fasta]
  • YGL252C [Saccharomyces cerevisiae] [nr-271106-contam.fasta]
  • Retrograde regulation protein 2 [nr-271106-contam.fasta]
  • RTG2 SGDID:S000003221, Chr VII from 27484-25718, reverse complement, Verified ORF, "Sensor of mitochondrial dysfunction; regulates the subcellular location of Rtg1p and Rtg3p, transcriptional activators of the retrograde (RTG) and TOR pathways; Rtg2p is inhibited by the phosphorylated form of Mks1p" [yeast-bovrabprots.fasta]
  • [chemostatdb.fasta]
  • Retrograde regulation protein 2 OS=Saccharomyces cerevisiae (strain ATCC 204508 / S288c) GN=RTG2 PE=1 SV=2 [UniProt_S_cerevisiae_20120516_05-16-2012_reversed.fasta]
  • RTG2 SGDID:S000003221, Chr VII from 27484-25718, Genome Release 64-1-1, reverse complement, Verified ORF, "Sensor of mitochondrial dysfunction; regulates the subcellular location of Rtg1p and Rtg3p, transcriptional activators of the retrograde (RTG) and TOR pathways; Rtg2p is inhibited by the phosphorylated form of Mks1p" [yeast-030211-contam.fasta]
  • RTG2 SGDID:S000003221, Chr VII from 27484-25718, Genome Release 64-2-1, reverse complement, Verified ORF, "Sensor of mitochondrial dysfunction; regulates the subcellular location of Rtg1p and Rtg3p, transcriptional activators of the retrograde (RTG) and TOR pathways; Rtg2p is inhibited by the phosphorylated form of Mks1p" [20141208_orf_trans.fasta]
  • TR5835|c0_g1_i1|g.4042 ORF TR5835|c0_g1_i1|g.4042 TR5835|c0_g1_i1|m.4042 type:complete len:589 (+) TR5835|c0_g1_i1:63-1829(+) [Y12_S_cerevisiae-Sep2015-contam.fasta]
  • TR5813|c0_g1_i1|g.4098 ORF TR5813|c0_g1_i1|g.4098 TR5813|c0_g1_i1|m.4098 type:complete len:589 (+) TR5813|c0_g1_i1:68-1834(+) [DBVPG6044_S_cerevisiae-Sep2015-contam.fasta]
  • YGL252C SGDID:S000003221, Chr VII from 27484-25718, Genome Release 64-1-1, reverse complement, Verified ORF, "Sensor of mitochondrial dysfunction; regulates the subcellular location of Rtg1p and Rtg3p, transcriptional activators of the retrograde (RTG) and TOR pathways; Rtg2p is inhibited by the phosphorylated form of Mks1p" [2016-01-SGD_Yeast_Contam_Riffle_20140507-Ska-Hec-110-tubulin.fasta]
  • asmbl_2071|g.970 ORF asmbl_2071|g.970 asmbl_2071|m.970 type:complete len:589 (+) asmbl_2071:61-1827(+) [DBVPG6044_Trinity_v2_2_0_PASA_6May2016-contam.fasta]
  • asmbl_2154|g.1475 ORF asmbl_2154|g.1475 asmbl_2154|m.1475 type:complete len:589 (+) asmbl_2154:61-1827(+) [Y12_Trinity_v2_2_0_PASA_6May2016-contam.fasta]
  • ID=asmbl_2074|g.1330 ORF ID=asmbl_2074|g.1330 ID=asmbl_2074|m.1330 type:complete len:589 (+) ID=asmbl_2074:61-1827(+) [DBVPG6044_quiverGenomes_Trinity_v2_2_0_PASA_2June2016-contam.fasta]
  • ID=asmbl_2158|g.1312 ORF ID=asmbl_2158|g.1312 ID=asmbl_2158|m.1312 type:complete len:589 (+) ID=asmbl_2158:61-1827(+) [Y12_quiver_Trinity_v2_2_0_PASA_2June2016-contam.fasta]
    • Organism: Saccharomyces cerevisiae
    Length: 588 amino acids

    Gene Ontology:
    Cellular Component: SLIK (SAGA-like) complex [IPILink to PubMed article]
    cytoplasm [IDALink to PubMed article][TASLink to PubMed article]
    Biological Process: extrachromosomal rDNA circle accumulation involved in replicative cell aging [IMPLink to PubMed article]
    mitochondria-nucleus signaling pathway [IMPLink to PubMed articleLink to PubMed article]
    Molecular Function: transcription regulator activity [IDALink to PubMed article][TASLink to PubMed article]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MSTLSDSDTE TEVVSRNLCG IVDIGSNGIR FSISSKAAHH ARIMPCVFKD RVGLSLYEVQ  60
   61 YNTHTNAKCP IPRDIIKEVC SAMKRFKLIC DDFGVPETSV RVIATEATRD AINADEFVNA 120
  121 VYGSTGWKVE ILGQEDETRV GIYGVVSSFN TVRGLYLDVA GGSTQLSWVI SSHGEVKQSS 180
  181 KPVSLPYGAG TLLRRMRTDD NRALFYEIKE AYKDAIEKIG IPQEMIDDAK KEGGFDLWTR 240
  241 GGGLRGMGHL LLYQSEGYPI QTIINGYACT YEEFSSMSDY LFLKQKIPGS SKEHKIFKVS 300
  301 DRRALQLPAV GLFMSAVFEA IPQIKAVHFS EGGVREGSLY SLLPKEIRAQ DPLLIASRPY 360
  361 APLLTEKYLY LLRTSIPQED IPEIVNERIA PALCNLAFVH ASYPKELQPT AALHVATRGI 420
  421 IAGCHGLSHR ARALIGIALC SRWGGNIPES EEKYSQELEQ VVLREGDKAE ALRIVWWTKY 480
  481 IGTIMYVICG VHPGGNIRDN VFDFHVSKRS EVETSLKELI IDDANTTKVK EESTRKNRGY 540
  541 EVVVRISKDD LKTSASVRSR IITLQKKVRK LSRGSVERVK IGVQFYEE

    Protein Complex Data

      PUBLICATION TOPOLOGY COCOMPLEXED PROTEINS
    View Details Riffle et al. (2010) (Unpublished Data) CDC34 CDC53 RTG2 RTT101
    View Details Krogan NJ, et al. (2006) MKS1 RTG2 YNL208W
    View Details Gavin AC, et al. (2006) MKS1 RTG2
    View Details Gavin AC, et al. (2002) ADE4 ASC1 BFR2 BMH1 BMH2 BMS1 BRX1 BUD21 CBF5 CFT2 CKA1 CKA2 CKB1 CKB2 CMS1 DBP8 DIA4 DIM1 DIP2 DIS3 ECM16 ECM29 EMG1 ENP1 ENP2 ERO1 ESF1 ESF2 FAP7 FIP1 GCN1 GLC7 HAS1 HCA4 HHF1, HHF2 HSL1 HTA2 IMP3 IMP4 KRE33 KRR1 LCP5 LTV1 MPP10 MRD1 MVD1 NAN1 NOB1 NOC2 NOC4 NOP1 NOP12 NOP14 NOP56 NOP58 NOP6 NTH1 NTH2 PAP1 PFS2 PIK1 PNO1 PRE6 PRE9 PRP43 PSK1 PTA1 PTI1 PWP2 RCL1 REF2 RML2 RNA14 ROK1 RPP2B RRP12 RRP7 RRP9 RTG2 SAM1 SCL1 SEC21 SLX9 SOF1 SRO9 TIF1, TIF2 TSR1 UTP10 UTP11 UTP13 UTP15 UTP18 UTP20 UTP21 UTP22 UTP30 UTP4 UTP6 UTP7 UTP8 UTP9 YOR059C YSH1

    Mass Spectrometry Data

    The following runs contain data for this protein:

      BAIT COMMENTS PUBLICATION
    View Run CEP3 sample cbf3 from feb 2005 Sandall S, et all (2006)
    View Run VAM3 Sample: HX11 - both fusion and trans-SNARE complex formation take place. Hao Xu, et al. (2010)
    View Run MLP2 #22 Asynchronous Prep2-IMAC Phosphopeptide enrichment B1-2 Keck JM, et al. (2011)

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    SHOWING SINGLE HITS. [ Hide Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

    No yeast two-hybrid interactions found for this protein.

    Microscopy / Localization Data

    New Feature: Upload Your Own Microscopy Data

      PROTEIN(S) PUBLICATION
    View Data RTG2 Huh WK, et al. (2003)

    Protein Structure Data


    [What does the above image mean?]
    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..134] ORFEUS 10.23 Prokaryotic actin homolog MreB
    2 View Details [135..351] ORFEUS 10.23 Prokaryotic actin homolog MreB
    3 View Details [352..524] MSA 1.040981 View MSA. No confident structure predictions are available.
    4 View Details [525..588] deduced N/A No confident structure predictions are available.

    Functions predicted (by domain):

    # Gene Ontology predictions
    1
    Term Confidence Notes
  • histone acetyltransferase activity
    		•  4.28232216932019 bayes_pls_golite062009
  • lysine N-acetyltransferase activity
    		•  4.28232216932019 bayes_pls_golite062009
  • N-acetyltransferase activity
    		•  2.69348633032984 bayes_pls_golite062009
  • N-acyltransferase activity
    		•  2.44825347420194 bayes_pls_golite062009
  • binding
    		•  2.11855816699924 bayes_pls_golite062009
  • acetyltransferase activity
    		•  2.07817518361957 bayes_pls_golite062009
  • protein binding
    		•  0.956664772028256 bayes_pls_golite062009
  • phosphoric ester hydrolase activity
    		•  0.746442016896597 bayes_pls_golite062009
  • kinase activity
    		•  0.745749848855807 bayes_pls_golite062009
  • phosphotransferase activity, alcohol group as acceptor
    		•  0.712286564783673 bayes_pls_golite062009
  • transferase activity, transferring phosphorus-containing groups
    		•  0.63007037584851 bayes_pls_golite062009
  • phosphoric diester hydrolase activity
    		•  0.620856934459228 bayes_pls_golite062009
  • cytoskeletal protein binding
    		•  0.368147081469877 bayes_pls_golite062009
  • transcription regulator activity
    		•  0.309839091488096 bayes_pls_golite062009
  • catalytic activity
    		•  0.296484721581333 bayes_pls_golite062009
  • structural constituent of cytoskeleton
    		•  0.28741807440215 bayes_pls_golite062009
  • cyclic-nucleotide phosphodiesterase activity
    		•  0.177818098644499 bayes_pls_golite062009
  • nucleic acid binding
    		•  0.103902068310965 bayes_pls_golite062009
  • DNA binding
    		•  0.0569764181525874 bayes_pls_golite062009
  • 3',5'-cyclic-nucleotide phosphodiesterase activity
    		•  0.0539674522232084 bayes_pls_golite062009
  • chromatin binding
    		•  0.0424425838189793 bayes_pls_golite062009
    2 No functions predicted.
    3 No functions predicted.
    4 No functions predicted.


    Reference: Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076


    Philius Transmembrane Prediction:

    Protein predicted to be: GLOBULAR (No transmembrane regions or signal peptide)
    Confidence of classification: 0.94

    Source: Reynolds et al. (2008)

    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle