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Catalysis of the hydrolysis of a phosphodiester to give a phosphomonoester and a free hydroxyl group. Catalysis of the reaction: nucleoside 3',5'-cyclic phosphate + H2O = nucleoside 5'-phosphate; catalytic activity is decreased in the presence of cGMP. Catalysis of the reaction: adenosine 3',5'-cyclic phosphate + H2O = adenosine 5'-phosphate. Catalysis of the reaction: nucleoside 3',5'-cyclic phosphate + H2O = nucleoside 5'-phosphate; catalytic activity is increased in the presence of cGMP. Catalysis of the reaction: nucleoside 3',5'-cyclic phosphate + H2O = nucleoside 5'-phosphate. Catalysis of the reaction: nucleoside 3',5'-cyclic phosphate + H2O = nucleoside 5'-phosphate; catalytic activity is regulated by calmodulin. Catalysis of the reaction: a nucleoside cyclic phosphate + H2O = a nucleoside phosphate. Catalysis of the reaction: guanosine 3',5'-cyclic phosphate + H2O = guanosine 5'-phosphate. Catalysis of the hydrolysis of bonds in a cyclic nucleotide (nucleoside cyclic phosphate + H2O = nucleoside phosphate).

View Gene Ontology (GO) Term

GO TERM SUMMARY
Name: 3',5'-cyclic-nucleotide phosphodiesterase activity
Acc: GO:0004114
Aspect: Molecular Function
Desc: Catalysis of the reaction: nucleoside 3',5'-cyclic phosphate + H2O = nucleoside 5'-phosphate.
Synonyms:
  • cyclic nucleotide phosphodiesterase activity
  • 3':5'-cyclic nucleotide 5'-nucleotidohydrolase activity
  • 3',5'-cyclic-nucleotide 5'-nucleotidohydrolase activity
  • cyclic 3',5'-nucleotide phosphodiesterase activity
  • nucleoside-3',5-monophosphate phosphodiesterase activity
  • cyclic 3',5'-phosphodiesterase activity
  • PDE
  • cyclic AMP phosphodiesterase activity
  • 3',5'-cyclonucleotide phosphodiesterase activity
  • 3': 5'-monophosphate phosphodiesterase (cyclic CMP) activity
  • 3', 5'-cyclic nucleoside monophosphate phosphodiesterase activity
  • cytidine 3':5'-monophosphate phosphodiesterase (cyclic CMP) activity
  • 3',5' cyclic-nucleotide phosphodiesterase activity
  • cyclic 3',5-nucleotide monophosphate phosphodiesterase activity
  • 3',5'-nucleotide phosphodiesterase activity
  • nucleoside 3',5'-cyclic phosphate diesterase activity
  • cyclic 3',5'-mononucleotide phosphodiesterase activity
Proteins in PDR annotated with:
   This term: 79 [Search]
   Term or descendants: 123 [Search]


[geneontology.org]
INTERACTIVE GO GRAPH

GO:0004114 - 3',5'-cyclic-nucleotide phosphodiesterase activity (interactive image map)
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