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Catalysis of the reaction: RPO-R' + H2O = RPOOH + R'H. This reaction is the hydrolysis of any phosphoric ester bond, any ester formed from orthophosphoric acid, O=P(OH)3. Catalysis of the hydrolysis of a phosphodiester to give a phosphomonoester and a free hydroxyl group. Catalysis of the reaction: nucleoside 3',5'-cyclic phosphate + H2O = nucleoside 5'-phosphate. Catalysis of the reaction: nucleoside 2',3'-cyclic phosphate + H2O = nucleoside 2'-phosphate. Catalysis of the reaction: a nucleoside cyclic phosphate + H2O = a nucleoside phosphate. Catalysis of the reaction: nucleoside 2',3'-cyclic phosphate + H2O = nucleoside 3'-phosphate.

View Gene Ontology (GO) Term

GO TERM SUMMARY
Name: cyclic-nucleotide phosphodiesterase activity
Acc: GO:0004112
Aspect: Molecular Function
Desc: Catalysis of the reaction: a nucleoside cyclic phosphate + H2O = a nucleoside phosphate.
Proteins in PDR annotated with:
   This term: 25 [Search]
   Term or descendants: 138 [Search]


[geneontology.org]
INTERACTIVE GO GRAPH

GO:0004112 - cyclic-nucleotide phosphodiesterase activity (interactive image map)
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