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Protein Overview: MKS1

General Information:
Name(s) found: MKS1 / YNL076W [SGD]
Description(s) found:
Found 25 descriptions.
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  • Pleiotropic negative transcriptional regulator involved in Ras-CAMP and lysine biosynthetic pathways and nitrogen regulation; involved in retrograde (RTG) mitochondria-to-nucleus signaling [SGD]
    • Organism: Saccharomyces cerevisiae
    Length: 584 amino acids

    Gene Ontology:
    Cellular Component: intracellular [ICLink to PubMed article]
    Biological Process: regulation of nitrogen utilization [IMPLink to PubMed article]
    mitochondria-nucleus signaling pathway [IPILink to PubMed article]
    Molecular Function: transcription repressor activity [IDALink to PubMed article]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MSREAFDVPN IGTNKFLKVT PNLFTPERLN LFDDVELYLT LIKASKCVEQ GERLHNISWR  60
   61 ILNKAVLKEH NINRSKKRDG VKNIYYVLNP NNKQPIKPKQ AAVKQPPLQK ANLPPTTAKQ 120
  121 NVLTRPMTSP AIAQGAHDRS LDNPNSTNND VKNDVAPNRQ FSKSTTSGLF SNFADKYQKM 180
  181 KNVNHVANKE EPQTIITGFD TSTVITKKPL QSRRSRSPFQ HIGDMNMNCI DNETSKSTSP 240
  241 TLENMGSRKS SFPQKESLFG RPRSYKNDQN GQLSLSKTSS RKGKNKIFFS SEDEDSDWDS 300
  301 VSNDSEFYAD EDDEEYDDYN EEEADQYYRR QWDKLLFAKN QQNLDSTKSS VSSANTINSN 360
  361 TSHDPVRKSL LSGLFLSEAN SNSNNHNTAH SEYASKHVSP TPQSSHSNIG PQPQQNPPSA 420
  421 NGIKQQKPSL KTSNVTALAS LSPPQPSNNE RLSMDIQKDF KTDNESNHLY ESNAPLTAQT 480
  481 ILPTALSTHM FLPNNIHQQR MAIATGSNTR HRFSRRQSMD IPSKNRNTGF LKTRMEISEE 540
  541 EKMVRTISRL DNTSIANSNG NGNDDTSNQR TEALGRKTSN GGRI

    Protein Complex Data

      PUBLICATION TOPOLOGY COCOMPLEXED PROTEINS
    View Details Krogan NJ, et al. (2006) MKS1 RTG2 YNL208W
    View Details Gavin AC, et al. (2006) GLN1 MCM2 MKS1 RTG2 TSC10
    View Details Gavin AC, et al. (2002) CTR3 DAL3 GLN1 GTO3 IML1 MCM2 MKS1 REG1 TIF1, TIF2 TPS1 TPS2 TPS3 TSC10 TSL1 YIL177C

    Mass Spectrometry Data

    The following runs contain data for this protein:

      BAIT COMMENTS PUBLICATION
    View Run CEP3 sample cbf3 from feb 2005 Sandall S, et all (2006)

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    NOT SHOWING SINGLE HITS. [ Show Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

    No yeast two-hybrid interactions found for this protein.

    Microscopy / Localization Data

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      PROTEIN(S) PUBLICATION
    View Data MKS1 Huh WK, et al. (2003)

    Protein Structure Data


    [What does the above image mean?]
    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..584] deduced N/A No confident structure predictions are available.


    Reference: Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076


    Philius Transmembrane Prediction:

    Protein predicted to be: GLOBULAR (No transmembrane regions or signal peptide)
    Confidence of classification: 0.99

    Source: Reynolds et al. (2008)

    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle