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Protein Overview: GLN1

General Information:
Name(s) found: GLN1 / YPR035W [SGD]
Description(s) found:
Found 16 descriptions.
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  • Glutamine synthetase (GS), synthesizes glutamine from glutamate and ammonia; with Glt1p, forms the secondary pathway for glutamate biosynthesis from ammonia; expression regulated by nitrogen source and by amino acid limitation [SGD]
    • Organism: Saccharomyces cerevisiae
    Length: 370 amino acids

    Gene Ontology:
    Cellular Component: cytoplasm [IDALink to PubMed articleLink to PubMed article]
    Biological Process: nitrogen compound metabolic process [IEPLink to PubMed article][ISSLink to PubMed article]
    glutamine biosynthetic process [TAS]
    Molecular Function: glutamate-ammonia ligase activity [IMPLink to PubMed article][ISSLink to PubMed article]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MAEASIEKTQ ILQKYLELDQ RGRIIAEYVW IDGTGNLRSK GRTLKKRITS IDQLPEWNFD  60
   61 GSSTNQAPGH DSDIYLKPVA YYPDPFRRGD NIVVLAACYN NDGTPNKFNH RHEAAKLFAA 120
  121 HKDEEIWFGL EQEYTLFDMY DDVYGWPKGG YPAPQGPYYC GVGAGKVYAR DMIEAHYRAC 180
  181 LYAGLEISGI NAEVMPSQWE FQVGPCTGID MGDQLWMARY FLHRVAEEFG IKISFHPKPL 240
  241 KGDWNGAGCH ANVSTKEMRQ PGGTKYIEQA IEKLSKRHAE HIKLYGSDND MRLTGRHETA 300
  301 SMTAFSSGVA NRGSSIRIPR SVAKEGYGYF EDRRPASNID PYLVTGIMCE TVCGAIDNAD 360
  361 MTKEFERESS

    Protein Complex Data

      PUBLICATION TOPOLOGY COCOMPLEXED PROTEINS
    View Details Riffle et al. (2010) (Unpublished Data) GLN1 HSP42
    View Details Krogan NJ, et al. (2006) GLN1 RPS0B
    View Details Gavin AC, et al. (2006) GLN1 HSP42 MCM2 MKS1 TSC10
    View Details Gavin AC, et al. (2002) CTR3 DAL3 GLN1 GTO3 IML1 MCM2 MKS1 REG1 TIF1, TIF2 TPS1 TPS2 TPS3 TSC10 TSL1 YIL177C

    Mass Spectrometry Data

    No mass spectrometry results found for this protein.

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    NOT SHOWING SINGLE HITS. [ Show Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

    No yeast two-hybrid interactions found for this protein.

    Microscopy / Localization Data

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      PROTEIN(S) PUBLICATION
    View Data GLN1 Huh WK, et al. (2003)

    Protein Structure Data


    [What does the above image mean?]
    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..106] PSI-BLAST 237.218487 Glutamine synthetase, N-terminal domain; Glutamine synthetase, C-terminal domain
    2 View Details [107..131]
    [244..370]    		 PSI-BLAST 237.218487 Glutamine synthetase, N-terminal domain; Glutamine synthetase, C-terminal domain
    3 View Details [132..243] PSI-BLAST 237.218487 Glutamine synthetase, N-terminal domain; Glutamine synthetase, C-terminal domain


    Reference: Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076


    Philius Transmembrane Prediction:

    Protein predicted to be: GLOBULAR (No transmembrane regions or signal peptide)
    Confidence of classification: 0.99

    Source: Reynolds et al. (2008)

    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle