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Protein Overview: TSC10

General Information:
Name(s) found: TSC10 / YBR265W [SGD]
Description(s) found:
Found 22 descriptions.
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  • 3-ketosphinganine reductase, catalyzes the second step in phytosphingosine synthesis, essential for growth in the absence of exogenous dihydrosphingosine or phytosphingosine, member of short chain dehydrogenase/reductase protein family [SGD]
    • Organism: Saccharomyces cerevisiae
    Length: 320 amino acids

    Gene Ontology:
    Cellular Component: cytoplasm [IDALink to PubMed article]
    endoplasmic reticulum [IDALink to PubMed articleLink to PubMed article]
    mitochondrial outer membrane [IDALink to PubMed article]
    Biological Process: 3-keto-sphinganine metabolic process [IDALink to PubMed article]
    sphingolipid biosynthetic process [IDALink to PubMed article][IMPLink to PubMed article][ISSLink to PubMed article]
    Molecular Function: oxidoreductase activity, acting on NADH or NADPH [IDALink to PubMed article]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MKFTLEDQVV LITGGSQGLG KEFAKKYYNE AENTKIIIVS RSEARLLDTC NEIRIEAHLR  60
   61 RETTDEGQVQ HKLAAPLDLE QRLFYYPCDL SCYESVECLF NALRDLDLLP TQTLCCAGGA 120
  121 VPKLFRGLSG HELNLGMDIN YKTTLNVAHQ IALAEQTKEH HLIIFSSATA LYPFVGYSQY 180
  181 APAKAAIKSL VAILRQELTN FRISCVYPGN FESEGFTVEQ LTKPEITKLI EGPSDAIPCK 240
  241 QACDIIAKSL ARGDEDVFTD FVGWMIMGMD LGLTAKKSRF VPLQWIFGVL SNILVVPFYM 300
  301 VGCSWYIRKW FRENDGKKAN

    Protein Complex Data

      PUBLICATION TOPOLOGY COCOMPLEXED PROTEINS
    View Details Gavin AC, et al. (2006) GLN1 MCM2 MKS1 TSC10
    View Details Gavin AC, et al. (2002) CTR3 DAL3 GLN1 GTO3 IML1 MCM2 MKS1 REG1 TIF1, TIF2 TPS1 TPS2 TPS3 TSC10 TSL1 YIL177C

    Mass Spectrometry Data

    No mass spectrometry results found for this protein.

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    NOT SHOWING SINGLE HITS. [ Show Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

    No yeast two-hybrid interactions found for this protein.

    Microscopy / Localization Data

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      PROTEIN(S) PUBLICATION
    View Data TSC10 Huh WK, et al. (2003)

    Protein Structure Data


    [What does the above image mean?]
    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..320] PSI-BLAST 68.522879 Glucose dehydrogenase

    Functions predicted (by domain):

    # Gene Ontology predictions
    1
    Term Confidence Notes
  • oxidoreductase activity
    		•  2.27962497742937 bayes_pls_golite062009
  • oxidoreductase activity, acting on CH-OH group of donors
    		•  2.05948871511302 bayes_pls_golite062009
  • oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor
    		•  1.97774592602866 bayes_pls_golite062009
  • catalytic activity
    		•  1.79741889688267 bayes_pls_golite062009


    Reference: Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076


    Philius Transmembrane Prediction:

    [View Details]
    Source: Reynolds et al. 2008. Manuscript submitted Philius confidence legend
    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle