Protein Overview: GTO3

General Information:
Name(s) found:	GTO3 / YMR251W [SGD]
Description(s) found: Found 26 descriptions. SHOW ALL	Omega class glutathione transferase; putative cytosolic localization [SGD]
Organism:	Saccharomyces cerevisiae
Length:	366 amino acids
Gene Ontology:
Cellular Component:	cytoplasm [IDA]
Biological Process:	glutathione metabolic process [ISS]
Molecular Function:	glutathione transferase activity [IDA][ISS]

Sequence:

Sequence:
[PDR BLAST]
[ProtParam]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MSEKSASNNK AEFKRQSSPF REIISADHPI YKPAKGRYWL YVALPCPWAQ RTLITRALKG  60
   61 LAPIIGCSVA HWHLDDKGWR FLEEGDGKTN ERHWFDIAGG ISSVNLNTST PVANIPNNAH 120
  121 RLLVDGTDEP HYGYKRLSDF YFKTKPDYKG RFTVPVLWDL ETCTIVNNES SDIIGIMNSA 180
  181 AFDEFVGEEY RQVRLVPRSL EAQITEFNSW VYDKINNGVY KAGFAECAEV YEREVTSLFQ 240
  241 YLDKLENLLD KKYTDLEAEY GKNNKDKILD RYFAIGDTLT EADVRLYPTI VRFDVVYHQH 300
  301 FKCNLATIRD DYSRIHTWLK NIYWRHEAFQ RTTDFTHIKL GYTRSQPRVN PIGITPLGPK 360
  361 PDIRPP

Protein Complex Data

	PUBLICATION	TOPOLOGY	COCOMPLEXED PROTEINS
View Details	Gavin AC, et al. (2002)		CTR3 DAL3 GLN1 GTO3 IML1 MCM2 MKS1 REG1 TIF1, TIF2 TPS1 TPS2 TPS3 TSC10 TSL1 YIL177C

Mass Spectrometry Data

No mass spectrometry results found for this protein.

Yeast Two-Hybrid Data

The following interactions contain this protein:

NOT SHOWING SINGLE HITS. [ Show Single Hits ]

[View our yeast two-hybrid interpretation guidelines.]

No yeast two-hybrid interactions found for this protein.

Microscopy / Localization Data

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No microscopy data found in the PDR for this protein.

Protein Structure Data

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[View Top Sequence Alignments] [Show Ginzu Version Information]

Domains predicted:

#		Region(s)	Method	Confidence	Match Description
1	View Details	[1..190]	PSI-BLAST	24.0	Class omega GST
2	View Details	[191..366]	deduced	N/A	No confident structure predictions are available.

Functions predicted (by domain):

#

Gene Ontology predictions

1

Term	Confidence	Notes
glutathione binding	2.07086805531749	bayes_pls_golite062009
glutathione transferase activity	1.85683051472829	bayes_pls_golite062009
antioxidant activity	1.78836688224506	bayes_pls_golite062009
peroxidase activity	1.62851025934188	bayes_pls_golite062009
oxidoreductase activity, acting on peroxide as acceptor	1.62851025934188	bayes_pls_golite062009
binding	1.1101496519064	bayes_pls_golite062009
glutathione peroxidase activity	1.08052084417939	bayes_pls_golite062009
oxidoreductase activity, acting on sulfur group of donors	1.0279404567142	bayes_pls_golite062009
catalytic activity	0.672192331361968	bayes_pls_golite062009
peroxiredoxin activity	0.366096607480921	bayes_pls_golite062009
protein binding	0.341730456502484	bayes_pls_golite062009
selenium binding	0.237008126838281	bayes_pls_golite062009
thioredoxin peroxidase activity	0.163136748643487	bayes_pls_golite062009

2

Term	Confidence	Notes
glutathione binding	1.77211489459567	bayes_pls_golite062009
glutathione transferase activity	1.4787810404032	bayes_pls_golite062009
antioxidant activity	1.3961148524753	bayes_pls_golite062009
peroxidase activity	1.2460437903417	bayes_pls_golite062009
oxidoreductase activity, acting on peroxide as acceptor	1.2460437903417	bayes_pls_golite062009
binding	1.18507788580647	bayes_pls_golite062009
oxidoreductase activity, acting on sulfur group of donors	0.699008336089393	bayes_pls_golite062009
glutathione peroxidase activity	0.651680638869122	bayes_pls_golite062009
catalytic activity	0.646676412582618	bayes_pls_golite062009
protein binding	0.376412693567268	bayes_pls_golite062009

Reference: Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076

Philius Transmembrane Prediction:

Protein predicted to be:	GLOBULAR (No transmembrane regions or signal peptide)
Confidence of classification:	0.93

Source: Reynolds et al. (2008)

YRC Informatics Platform - Version 3.0
Created and Maintained by: Michael Riffle