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Protein Overview: TPS3

General Information:
Name(s) found: TPS3 / YMR261C [SGD]
Description(s) found:
Found 25 descriptions.
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  • Regulatory subunit of trehalose-6-phosphate synthase/phosphatase complex, which synthesizes the storage carbohydrate trehalose; expression is induced by stress conditions and repressed by the Ras-cAMP pathway [SGD]
    • Organism: Saccharomyces cerevisiae
    Length: 1054 amino acids

    Gene Ontology:
    Cellular Component: alpha,alpha-trehalose-phosphate synthase complex (UDP-forming) [IGILink to PubMed article][IMPLink to PubMed article][IPILink to PubMed article]
    Biological Process: trehalose biosynthetic process [IGILink to PubMed article][IMPLink to PubMed article][IPILink to PubMed article]
    response to stress [IMPLink to PubMed article]
    Molecular Function: alpha,alpha-trehalose-phosphate synthase (UDP-forming) activity [IMPLink to PubMed article][ISSLink to PubMed article]
    trehalose-phosphatase activity [IGILink to PubMed article]
    enzyme regulator activity [IMPLink to PubMed article][ISSLink to PubMed article]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MTIIVASLFL PYTPQFEADV TNSDTAKLVE SSMIKVDCNN QELSNNKQER SSSVTSASSH  60
   61 YIGLPQEAQI NGEPLQRANV GSPATGVNYH NEMEMLSSEQ FLEELTANAT HAANSGIPPA 120
  121 NNPVSSGSTA QRPSVEEFFS APSARVCSPS QEASASSISA SRSSAHHNDL SSSLMKNPNL 180
  181 SFDSHPPRVR SSSKSAVITP VSKSVPDVDP AVVDVAKVRE EFQQQASLPS MKRVSGSTAG 240
  241 DSSIASSSSN LRYSQQFQDN FIEDTDSEDD IDSDLETDAT KKYNVPKFGG YSNNAKLRAS 300
  301 LMRNSYELFK HLPWTIVDSD KGNGSLKNAV NIAVAEKTVK EPVSWVGTMG IPTDELPHEV 360
  361 CHKISKKLEQ DFSSFPVVTD DITFKGAYKN YAKQILWPTL HYQIPDNPNS KAFEDHSWDY 420
  421 YQKVNQKFSD RIVSVYKPGD TIWIHDYHLM LVPQMVREKL PKAKIGFFLH VSFPSSEVFR 480
  481 CLANRERILE GIIGANFVGF QTKEYKRHFL QTCNRLLAAD VSNDEVKYHC NIVSVMYAPI 540
  541 GIDYYHLTSQ LRNGSVLEWR QLIKERWRNK KLIVCRDQFD RIRGLQKKML AYERFLIENP 600
  601 EYIEKVVLIQ ICIGKSSDPE YERQIMVVVD RINSLSSNIS ISQPVVFLHQ DLDFAQYLAL 660
  661 NCEADVFLVD ALREGMNLTC HEFIVSSFEK NAPLLLSEFT GSSSVLKEGA ILINPWDINH 720
  721 VAQSIKRSLE MSPEEKRRRW KKLFKSVIEH DSDNWITKCF EYINNAWESN QETSTVFNLA 780
  781 PEKFCADYKA SKKHLFIFKI SEPPTSRMLS LLSELSSNNI VYVLSSFTKN TFESLYNGVL 840
  841 NIGLIAENGA YVRVNGSWYN IVEELDWMKE VAKIFDEKVE RLPGSYYKIA DSMIRFHTEN 900
  901 ADDQDRVPTV IGEAITHINT LFDDRDIHAY VHKDIVFVQQ TGLALAAAEF LMKFYNSGVS 960
  961 PTDNSRISLS RTSSSMSVGN NKKHFQNQVD FVCVSGSTSP IIEPLFKLVK QEVEKNNLKF1020
 1021 GYTILYGSSR STYAKEHING VNELFTILHD LTAA

    Protein Complex Data

      PUBLICATION TOPOLOGY COCOMPLEXED PROTEINS
    View Details Riffle et al. (2010) (Unpublished Data) TPS1 TPS2 TPS3 TSL1
    View Details Krogan NJ, et al. (2006) TPS1 TPS2 TPS3 TSL1
    View Details Gavin AC, et al. (2002) CTR3 DAL3 GLN1 GTO3 IML1 MCM2 MKS1 REG1 TIF1, TIF2 TPS1 TPS2 TPS3 TSC10 TSL1 YIL177C
    View Details Qiu et al. (2008) GIP2 REG1 TPS1 TPS2 TPS3

    Mass Spectrometry Data

    The following runs contain data for this protein:

      BAIT COMMENTS PUBLICATION
    View Run RPA135 No Comments Schneider, DA, et al. (2006)
    View Run RLF2 phosphorylation data - cascade search Green EM, et al (2005)
    View Run MLP2 #24 Asynchronous Prep3-TiO2 Phosphopeptide enrichment Keck JM, et al. (2011)

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    NOT SHOWING SINGLE HITS. [ Show Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

    No yeast two-hybrid interactions found for this protein.

    Microscopy / Localization Data

    New Feature: Upload Your Own Microscopy Data

      PROTEIN(S) PUBLICATION
    View Data TPS3 Huh WK, et al. (2003)

    Protein Structure Data


    [What does the above image mean?]
    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..250] MSA 48.290997 View MSA. No confident structure predictions are available.
    2 View Details [251..775] Pfam 254.356547 Glycosyltransferase family 20 No confident structure predictions are available.
    3 View Details [776..1054] Pfam 71.920819 Trehalose-phosphatase No confident structure predictions are available.
    4 View Details [779..1054] PSI-BLAST 11.09691 Crystal structure of trehalose-6-phosphate phosphatase related protein

    Functions predicted (by domain):

    # Gene Ontology predictions
    1 No functions predicted.
    2 No functions predicted.
    3
    Term Confidence Notes
  • alpha,alpha-trehalose-phosphate synthase (UDP-forming) activity
    		•  11.2045941324603 bayes_pls_golite062009
  • glucosyltransferase activity
    		•  8.25064561355471 bayes_pls_golite062009
  • UDP-glucosyltransferase activity
    		•  8.0463972704113 bayes_pls_golite062009
  • trehalose-phosphatase activity
    		•  7.58500038184065 bayes_pls_golite062009
  • transferase activity, transferring hexosyl groups
    		•  3.70184884300914 bayes_pls_golite062009
  • catalytic activity
    		•  2.65148466065976 bayes_pls_golite062009
  • transferase activity, transferring glycosyl groups
    		•  2.62403914335522 bayes_pls_golite062009
  • transferase activity
    		•  2.18054407163329 bayes_pls_golite062009
  • UDP-glycosyltransferase activity
    		•  2.13085705769565 bayes_pls_golite062009
  • carbohydrate phosphatase activity
    		•  0.78952375993773 bayes_pls_golite062009
  • UDP-N-acetylglucosamine 2-epimerase activity
    		•  0.690032302126686 bayes_pls_golite062009
  • glycogen phosphorylase activity
    		•  0.607220464589157 bayes_pls_golite062009
  • binding
    		•  0.345236672370351 bayes_pls_golite062009
  • phosphorylase activity
    		•  0.296436712681472 bayes_pls_golite062009
  • mannosyltransferase activity
    		•  0.253888301381021 bayes_pls_golite062009
  • protein binding
    		•  0.198267161626932 bayes_pls_golite062009
    4
    Term Confidence Notes
  • trehalose-phosphatase activity
    		•  3.78859922218487 bayes_pls_golite062009
  • transporter activity
    		•  2.28749015584769 bayes_pls_golite062009
  • hydrolase activity
    		•  2.23636068759523 bayes_pls_golite062009
  • transmembrane transporter activity
    		•  2.17051010073814 bayes_pls_golite062009
  • substrate-specific transporter activity
    		•  2.14633664297706 bayes_pls_golite062009
  • substrate-specific transmembrane transporter activity
    		•  2.05684652641195 bayes_pls_golite062009
  • ion transmembrane transporter activity
    		•  2.05060633349756 bayes_pls_golite062009
  • cation transmembrane transporter activity
    		•  1.84740904871745 bayes_pls_golite062009
  • catalytic activity
    		•  1.55296860681783 bayes_pls_golite062009
  • ATPase activity, coupled to transmembrane movement of ions
    		•  1.53201151596704 bayes_pls_golite062009
  • inorganic cation transmembrane transporter activity
    		•  1.45647470429539 bayes_pls_golite062009
  • ATPase activity, coupled
    		•  1.44542004757594 bayes_pls_golite062009
  • nucleoside-triphosphatase activity
    		•  1.42792997211574 bayes_pls_golite062009
  • ATPase activity
    		•  1.40341876769691 bayes_pls_golite062009
  • pyrophosphatase activity
    		•  1.352553895791 bayes_pls_golite062009
  • ATPase activity, coupled to transmembrane movement of ions, phosphorylative mechanism
    		•  1.33388154652051 bayes_pls_golite062009
  • hydrolase activity, acting on acid anhydrides
    		•  1.33292469269496 bayes_pls_golite062009
  • hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides
    		•  1.33065047107664 bayes_pls_golite062009
  • metal ion transmembrane transporter activity
    		•  1.31602086166435 bayes_pls_golite062009
  • di-, tri-valent inorganic cation transmembrane transporter activity
    		•  0.28050944646617 bayes_pls_golite062009
  • active transmembrane transporter activity
    		•  0.194344891491143 bayes_pls_golite062009
  • phosphatase activity
    		•  0.159899259988948 bayes_pls_golite062009
  • cation-transporting ATPase activity
    		•  0.15490458026932 bayes_pls_golite062009
  • phosphoric ester hydrolase activity
    		•  0.103902756538853 bayes_pls_golite062009
  • primary active transmembrane transporter activity
    		•  0.053543166906854 bayes_pls_golite062009
  • P-P-bond-hydrolysis-driven transmembrane transporter activity
    		•  0.041293091790546 bayes_pls_golite062009
  • binding
    		•  0.0209333912048011 bayes_pls_golite062009


    Reference: Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076


    Philius Transmembrane Prediction:

    Protein predicted to be: GLOBULAR (No transmembrane regions or signal peptide)
    Confidence of classification: 0.56

    Source: Reynolds et al. (2008)

    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle