YRC Public Data Repository - Protein Structure Prediction

Protein:	TSC10
Organism:	Saccharomyces cerevisiae
Length:	320 amino acids
Reference:	Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076

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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for TSC10.

Description	E-value	Query Range	Subject Range
gi\|25283158 - pir\|\|C83961 3-oxoacyl-(acyl-carrier protein) reductase fabG [imported] - Bacillus halodurans (strain... gi\|10175111, gi\|... - gi\|15615054\|ref\|NP_243357.1\| 3-oxoacyl-(acyl-carrier protein) reductase [Bacillus halodurans C-125],...	2.0E-77	[5..274]	[2..246]
FABG_THEMA - 3-oxoacyl-[acyl-carrier-protein] reductase FabG OS=Thermotoga maritima GN=fabG PE=3 SV=1 FABG_THEMA - 3-oxoacyl-[acyl-carrier-protein] reductase FabG OS=Thermotoga maritima (strain ATCC 43589 / MSB8 / D...	6.0E-76	[4..271]	[2..243]
gi\|1502421 - gi\|1502421\|gb\|AAC44307.1\| 3-ketoacyl-acyl carrier protein reductase gi\|1502421\|gb\|AA... - 3-ketoacyl-acyl carrier protein reductase	2.0E-74	[5..274]	[2..246]
gi\|221313791 - gi\|221313791\|ref\|ZP_03595596.1\| beta-ketoacyl-acyl carrier protein reductase [Bacillus subtilis subs... gi\|221318715 - gi\|221318715\|ref\|ZP_03600009.1\| beta-ketoacyl-acyl carrier protein reductase [Bacillus subtilis subs... gi\|221322986 - gi\|221322986\|ref\|ZP_03604280.1\| beta-ketoacyl-acyl carrier protein reductase [Bacillus subtilis subs... FABG_BACSU - 3-oxoacyl-[acyl-carrier-protein] reductase FabG OS=Bacillus subtilis GN=fabG PE=3 SV=3 FABG_BACSU - 3-oxoacyl-[acyl-carrier-protein] reductase FabG OS=Bacillus subtilis (strain 168) GN=fabG PE=3 SV=3	3.0E-74	[5..274]	[2..246]
gi\|18310052, gi\|... - gi\|18310052\|ref\|NP_561986.1\| 3-ketoacyl-(acyl-carrier-protein) reductase [Clostridium perfringens st...	3.0E-74	[5..274]	[2..246]
gi\|90429999, gi\|... - gi\|90586379\|ref\|ZP_01242077.1\| 3-oxoacyl-(acyl-carrier-protein) reductase [Staphylococcus aureus sub... gi\|82750835, gi\|... - gi\|82750835\|ref\|YP_416576.1\| 3-oxoacyl-(acyl-carrier protein) reductase [Staphylococcus aureus RF122... gi\|90426550, gi\|... - gi\|90584394\|ref\|ZP_01240127.1\| 3-oxoacyl-(acyl-carrier-protein) reductase [Staphylococcus aureus sub... FABG_STAAC - 3-oxoacyl-[acyl-carrier-protein] reductase FabG OS=Staphylococcus aureus (strain COL) GN=fabG PE=3 S... gi\|227558554, gi... - gi\|227558554\|ref\|ZP_03988601.1\| 3-oxoacyl-(acyl-carrier protein) reductase [Staphylococcus aureus su... gi\|227900345, gi... - gi\|227900345\|ref\|ZP_04018150.1\| 3-oxoacyl-(acyl-carrier protein) reductase [Staphylococcus aureus su... gi\|251814140, gi... - gi\|251814140\|ref\|ZP_04828613.1\| 3-oxoacyl-(acyl-carrier protein) reductase [Staphylococcus aureus su... gi\|253728585, gi... - gi\|253733531\|ref\|ZP_04867696.1\| 3-oxoacyl-(acyl-carrier protein) reductase [Staphylococcus aureus su... gi\|161509402, gi... - gi\|161509402\|ref\|YP_001575061.1\| 3-oxoacyl-[acyl-carrier-protein] reductase [Staphylococcus aureus s... FABG_STAAN - 3-oxoacyl-[acyl-carrier-protein] reductase FabG OS=Staphylococcus aureus (strain N315) GN=fabG PE=1 ... FABG_STAAR - 3-oxoacyl-[acyl-carrier-protein] reductase FabG OS=Staphylococcus aureus (strain MRSA252) GN=fabG PE... FABG_STAAS - 3-oxoacyl-[acyl-carrier-protein] reductase FabG OS=Staphylococcus aureus (strain MSSA476) GN=fabG PE... gi\|156721687, gi... - gi\|156979552\|ref\|YP_001441811.1\| 3-oxoacyl-#acyl-carrier protein reductase [Staphylococcus aureus su... gi\|25283236, gi\|... - pir\|\|B89896 3-oxoacyl-(acyl-carrier protein) reductase [imported] - Staphylococcus aureus (strain N3... FABG_STAAW - 3-oxoacyl-[acyl-carrier-protein] reductase FabG OS=Staphylococcus aureus (strain MW2) GN=fabG PE=3 S... FABG_STAAM - 3-oxoacyl-[acyl-carrier-protein] reductase FabG OS=Staphylococcus aureus (strain Mu50 / ATCC 700699)...	5.0E-73	[8..274]	[5..246]
gi\|16800987 - gi\|16800987\|ref\|NP_471255.1\| hypothetical protein lin1921 [Listeria innocua Clip11262] gi\|25283285, gi\|... - pir\|\|AG1672 3-ketoacyl-acyl carrier protein reductase homolog fabG [imported] - Listeria innocua (st...	4.0E-72	[5..274]	[3..247]
gi\|16803847 - gi\|16803847\|ref\|NP_465332.1\| hypothetical protein lmo1807 [Listeria monocytogenes EGD-e] gi\|25283283, gi\|... - pir\|\|AG1300 3-ketoacyl-acyl carrier protein reductase homolog fabG [imported] - Listeria monocytogen... gi\|224501391 - gi\|224501391\|ref\|ZP_03669698.1\| hypothetical protein LmonFR_02530 [Listeria monocytogenes FSL R2-561... gi\|254831591, gi... - gi\|254831591\|ref\|ZP_05236246.1\| hypothetical protein Lmon1_09568 [Listeria monocytogenes 10403S], gi...	6.0E-72	[5..274]	[3..247]
FABG_AQUAE - 3-oxoacyl-[acyl-carrier-protein] reductase FabG OS=Aquifex aeolicus (strain VF5) GN=fabG PE=1 SV=1 FABG_AQUAE - 3-oxoacyl-[acyl-carrier-protein] reductase FabG OS=Aquifex aeolicus GN=fabG PE=1 SV=1	2.0E-71	[1..273]	[1..248]
TRNHF_ARATH - Tropinone reductase homolog At5g06060 OS=Arabidopsis thaliana GN=At5g06060 PE=2 SV=1	5.0E-71	[3..281]	[7..261]

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Predicted Domain #1

Region A:
Residues: [1-320]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MKFTLEDQVV LITGGSQGLG KEFAKKYYNE AENTKIIIVS RSEARLLDTC NEIRIEAHLR  60
   61 RETTDEGQVQ HKLAAPLDLE QRLFYYPCDL SCYESVECLF NALRDLDLLP TQTLCCAGGA 120
  121 VPKLFRGLSG HELNLGMDIN YKTTLNVAHQ IALAEQTKEH HLIIFSSATA LYPFVGYSQY 180
  181 APAKAAIKSL VAILRQELTN FRISCVYPGN FESEGFTVEQ LTKPEITKLI EGPSDAIPCK 240
  241 QACDIIAKSL ARGDEDVFTD FVGWMIMGMD LGLTAKKSRF VPLQWIFGVL SNILVVPFYM 300
  301 VGCSWYIRKW FRENDGKKAN

[Run NCBI BLAST on this sequence.]

Detection Method:	PSI-BLAST
Confidence:	68.522879
Match:	1gcoA_
Description:	Glucose dehydrogenase
Matching Structure (courtesy of the PDB):

Predicted functions:

Term	Confidence	Notes
oxidoreductase activity	2.27962497742937	bayes_pls_golite062009
oxidoreductase activity, acting on CH-OH group of donors	2.05948871511302	bayes_pls_golite062009
oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor	1.97774592602866	bayes_pls_golite062009
catalytic activity	1.79741889688267	bayes_pls_golite062009

TMHMM	2.0c	PSIPRED	v2.61
SignalP	3.0	COILS	1999
DISOPRED	v0.1	NCBI nr	06/2007
PSI-BLAST	2.2.18	FFAS	ffas03
PDB	06/2007	Pfam	22
HMMER	2.3.2

View Structure Prediction Details

Top Sequence Alignment Hits

Predicted functions: