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Protein Overview: TSA2

General Information:
Name(s) found: TSA2 / YDR453C [SGD]
Description(s) found:
Found 27 descriptions.
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  • Stress inducible cytoplasmic thioredoxin peroxidase; cooperates with Tsa1p in the removal of reactive oxygen, nitrogen and sulfur species using thioredoxin as hydrogen donor; deletion enhances the mutator phenotype of tsa1 mutants [SGD]
    • Organism: Saccharomyces cerevisiae
    Length: 196 amino acids

    Gene Ontology:
    Cellular Component: cytoplasm [IDALink to PubMed article]
    Biological Process: response to oxidative stress [IGILink to PubMed article]
    Molecular Function: thioredoxin peroxidase activity [IDALink to PubMed article][IMPLink to PubMed article][ISSLink to PubMed article]
    peroxiredoxin activity [IDALink to PubMed article]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MVAEVQKQAP PFKKTAVVDG IFEEISLEKY KGKYVVLAFV PLAFSFVCPT EIVAFSDAAK  60
   61 KFEDQGAQVL FASTDSEYSL LAWTNLPRKD GGLGPVKVPL LADKNHSLSR DYGVLIEKEG 120
  121 IALRGLFIID PKGIIRHITI NDLSVGRNVN EALRLVEGFQ WTDKNGTVLP CNWTPGAATI 180
  181 KPDVKDSKEY FKNANN

    Protein Complex Data

      PUBLICATION TOPOLOGY COCOMPLEXED PROTEINS
    View Details Krogan NJ, et al. (2006) TSA1 TSA2
    View Details Ho Y, et al. (2002) AAT2 ACC1 ACH1 ACO1 ADH2 ADK1 ADR1 AFR1 AHP1 APT1 ARC1 ARF1 ARO1 ATP3 ATP5 ATP7 CAR2 CDC14 CDC33 CDC39 CLU1 COF1 COR1 CPR1 CYR1 CYS4 DCS1 DCS2 DPM1 DSS1 ECM10 EGD1 ERG13 ERG6 FPR1 FRS2 FUR1 GCD11 GDB1 GFA1 GLC7 GND1 GND2 GRX1 GUS1 HEF3 HHF1, HHF2 HMS1 HTB2 HTZ1 IDH2 ISA2 LRO1 LSP1 MCR1 MDH1 MET18 MET6 MTC5 NGL2 NTF2 OLA1 OYE2 PFK1 PIL1 PRE1 PRM2 PST2 PUP3 PYC1 PYC2 RAD16 RAD50 RAD7 RET1 RNR2 RPA135 RPA190 RPA49 RPB5 RPC19 RPC25 RPC34 RPC40 RPC82 RPN3 RPO26 RPO31 RSN1 RVS167 SAH1 SCP160 SEC27 SEC53 SEN15 SES1 SHP1 SNF4 SNU13 SOD1 SOD2 SPE3 SSZ1 TBS1 TEF4 TFP1 THS1 TIF1, TIF2 TMA19 TMA29 TPS1 TSA2 UBA1 UBP15 UBR1 VAS1 VMA4 VMA5 VPS1 WTM1 YAK1 YFL042C YHR033W YHR112C YKU80 YLR241W YNK1 YPL247C

    Mass Spectrometry Data

    The following runs contain data for this protein:

      BAIT COMMENTS PUBLICATION
    View Run MLP2 #25 Asynchronous Prep3-TiO2 Flowthrough Keck JM, et al. (2011)

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    SHOWING SINGLE HITS. [ Hide Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

      BAIT PREY HITS PUBLICATION
    View Screen HNT1 TSA2 2 Unpublished Fields Lab Data
    View Screen TWF1 TSA2 1 Unpublished Fields Lab Data
    View Screen LOS1 TSA2 1 Unpublished Fields Lab Data
    View Screen YKU80 TSA2 1 Unpublished Fields Lab Data
    View Screen SPO1 TSA2 1 Unpublished Fields Lab Data

    Microscopy / Localization Data

    New Feature: Upload Your Own Microscopy Data

      PROTEIN(S) PUBLICATION
    View Data TSA2 Huh WK, et al. (2003)

    Protein Structure Data


    [What does the above image mean?]
    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..196] PSI-BLAST 733.67837 Thioredoxin peroxidase 2 (thioredoxin peroxidase B, 2-cys peroxiredoxin)

    Functions predicted (by domain):

    # Gene Ontology predictions
    1
    Term Confidence Notes
  • alkyl hydroperoxide reductase activity
    		•  4.29610283853788 bayes_pls_golite062009
  • antioxidant activity
    		•  3.8464796631544 bayes_pls_golite062009
  • peroxidase activity
    		•  3.43831566988273 bayes_pls_golite062009
  • oxidoreductase activity, acting on peroxide as acceptor
    		•  3.43831566988273 bayes_pls_golite062009
  • selenium binding
    		•  2.92496040718744 bayes_pls_golite062009
  • glutathione peroxidase activity
    		•  2.56524997297011 bayes_pls_golite062009
  • transcription regulator activity
    		•  2.30799114442278 bayes_pls_golite062009
  • oxidoreductase activity, acting on sulfur group of donors
    		•  2.23310780102446 bayes_pls_golite062009
  • peroxiredoxin activity
    		•  2.12777217096121 bayes_pls_golite062009
  • thioredoxin peroxidase activity
    		•  1.96134566495756 bayes_pls_golite062009
  • protein disulfide oxidoreductase activity
    		•  1.47769936616412 bayes_pls_golite062009
  • disulfide oxidoreductase activity
    		•  1.32811008894503 bayes_pls_golite062009
  • transferase activity
    		•  1.26687471229876 bayes_pls_golite062009
  • binding
    		•  1.25802922431343 bayes_pls_golite062009
  • protein binding
    		•  1.18479617596618 bayes_pls_golite062009
  • molecular transducer activity
    		•  1.11518182894524 bayes_pls_golite062009
  • signal transducer activity
    		•  1.11518182894524 bayes_pls_golite062009
  • catalytic activity
    		•  0.672192331361968 bayes_pls_golite062009
  • peptide binding
    		•  0.374493676068876 bayes_pls_golite062009
    		• 0.359224524631956 bayes_pls_golite062009
  • NADH dehydrogenase activity
    		•  0.23291471505999 bayes_pls_golite062009
  • copper ion binding
    		•  0.178842772364502 bayes_pls_golite062009
  • NADH dehydrogenase (ubiquinone) activity
    		•  0.16328723676608 bayes_pls_golite062009
  • NADH dehydrogenase (quinone) activity
    		•  0.0434052164026002 bayes_pls_golite062009


    Reference: Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076


    Philius Transmembrane Prediction:

    Protein predicted to be: GLOBULAR (No transmembrane regions or signal peptide)
    Confidence of classification: 0.80

    Source: Reynolds et al. (2008)

    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle