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View Structure Prediction Details

Protein: TSA2
Organism: Saccharomyces cerevisiae
Length: 196 amino acids
Reference: Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076



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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for TSA2.

Description E-value Query
Range
Subject
Range
gi|51980440 - gb|AAH82149.1| Unknown (protein for MGC:98395) [Xenopus laevis]
PRDX2_MOUSE - Peroxiredoxin-2 OS=Mus musculus GN=Prdx2 PE=1 SV=3
1.0E-79 [3..195] [6..198]
gi|7507776 - gi|7507776|pir||T16867 probable cytochrome P450 T13C5.1 [similarity] - Caenorhabditis elegans
2.0E-79 [3..195] [6..198]
gi|632720 - gi|632720|gb|AAB32034.1| TSA=thiol-specific antioxidant [rats, brain, Peptide, 198 aa]
PRDX2_RAT - Peroxiredoxin-2 OS=Rattus norvegicus GN=Prdx2 PE=1 SV=3
2.0E-79 [3..195] [6..198]
PRDX2_BOVIN - Peroxiredoxin-2 OS=Bos taurus GN=PRDX2 PE=2 SV=1
4.0E-79 [3..195] [7..199]
gi|9955015, gi|9... - gi|9955016|pdb|1QMV|J Chain J, Thioredoxin Peroxidase B From Red Blood Cells, gi|9955015|pdb|1QMV|I ...
5.0E-79 [3..195] [5..197]
gi|19698783 - gi|19698783|gb|AAL91102.1| thiredoxin peroxidase [Acanthocheilonema viteae]
4.0E-77 [5..196] [10..201]
gi|3193232 - gi|3193232|gb|AAC77922.1| peroxidoxin-2 [Onchocerca ochengi]
6.0E-77 [5..194] [10..199]

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Predicted Domain #1
Region A:
Residues: [1-196]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MVAEVQKQAP PFKKTAVVDG IFEEISLEKY KGKYVVLAFV PLAFSFVCPT EIVAFSDAAK  60
   61 KFEDQGAQVL FASTDSEYSL LAWTNLPRKD GGLGPVKVPL LADKNHSLSR DYGVLIEKEG 120
  121 IALRGLFIID PKGIIRHITI NDLSVGRNVN EALRLVEGFQ WTDKNGTVLP CNWTPGAATI 180
  181 KPDVKDSKEY FKNANN

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 733.67837
Match: 1qmvA_
Description: Thioredoxin peroxidase 2 (thioredoxin peroxidase B, 2-cys peroxiredoxin)
Matching Structure (courtesy of the PDB):

Predicted functions:

Term Confidence Notes
alkyl hydroperoxide reductase activity 4.29610283853788 bayes_pls_golite062009
antioxidant activity 3.8464796631544 bayes_pls_golite062009
peroxidase activity 3.43831566988273 bayes_pls_golite062009
oxidoreductase activity, acting on peroxide as acceptor 3.43831566988273 bayes_pls_golite062009
selenium binding 2.92496040718744 bayes_pls_golite062009
glutathione peroxidase activity 2.56524997297011 bayes_pls_golite062009
transcription regulator activity 2.30799114442278 bayes_pls_golite062009
oxidoreductase activity, acting on sulfur group of donors 2.23310780102446 bayes_pls_golite062009
peroxiredoxin activity 2.12777217096121 bayes_pls_golite062009
thioredoxin peroxidase activity 1.96134566495756 bayes_pls_golite062009
protein disulfide oxidoreductase activity 1.47769936616412 bayes_pls_golite062009
disulfide oxidoreductase activity 1.32811008894503 bayes_pls_golite062009
transferase activity 1.26687471229876 bayes_pls_golite062009
binding 1.25802922431343 bayes_pls_golite062009
protein binding 1.18479617596618 bayes_pls_golite062009
molecular transducer activity 1.11518182894524 bayes_pls_golite062009
signal transducer activity 1.11518182894524 bayes_pls_golite062009
catalytic activity 0.672192331361968 bayes_pls_golite062009
peptide binding 0.374493676068876 bayes_pls_golite062009
0.359224524631956 bayes_pls_golite062009
NADH dehydrogenase activity 0.23291471505999 bayes_pls_golite062009
copper ion binding 0.178842772364502 bayes_pls_golite062009
NADH dehydrogenase (ubiquinone) activity 0.16328723676608 bayes_pls_golite062009
NADH dehydrogenase (quinone) activity 0.0434052164026002 bayes_pls_golite062009

YRC Informatics Platform - Version 3.0
Created and Maintained by: Michael Riffle