Protein Overview: RAD52

General Information:
Name(s) found:	RAD52 / YML032C [SGD]
Description(s) found: SHOW ONLY BEST	gi\|27808713\|ref\|NP_013680.2\| Protein that stimulates strand exchange by facilitating Rad51p binding to single-stranded DNA; anneals complementary single-stranded DNA; involved in the repair of double-strand breaks in DNA during vegetative growth and meios [NCBI NR] gi\|109940131\|sp\|P06778.2\|RAD52_YEAST RecName: Full=DNA repair and recombination protein RAD52 [NCBI NR] DNA repair and recombination protein RAD52 OS=Saccharomyces cerevisiae GN=RAD52 PE=1 SV=2 [Swiss-Prot] RAD52 Recombination and DNA repair protein [mips] Protein that stimulates strand exchange by facilitating Rad51p binding to single-stranded DNA; anneals complementary single-stranded DNA; involved in the repair of double-strand breaks in DNA during vegetative growth and meiosis [SGD] Chr XIII from 212515-213930, reverse complement [yeastorf4.fasta] Chr XIII from 213930-212515, reverse complement [yeastorf5.fasta] RAD52 SGDID:S0004494, Chr XIII from 213930-212515, reverse complement, Verified ORF [yeastflysequest.fasta] Protein that stimulates strand exchange by facilitating Rad51p binding to single-stranded DNA; anneals complementary single-stranded DNA; involved in the repair of double-strand breaks in DNA during vegetative growth and meiosis [Saccharomyces cerevisiae] [nrdb_11152004_Chlamydomonas] RAD52 SGDID:S000004494, Chr XIII from 213930-212515, reverse complement, Verified ORF, "Protein that stimulates strand exchange by facilitating Rad51p binding to single-stranded DNA; anneals complementary single-stranded DNA; involved in the repair of dou [SGD_S-cerevisiae_na_12-16-2005_con_reversed.fasta] DNA repair and recombination protein RAD52 [nr-271106-contam.fasta] Protein that stimulates strand exchange by facilitating Rad51p binding to single-stranded DNA; anneals complementary single-stranded DNA; involved in the repair of double-strand breaks in DNA during vegetative growth and meiosis; Rad52p [Saccharomyces cer [nr-271106-contam.fasta] RAD52 SGDID:S000004494, Chr XIII from 213930-212515, reverse complement, Verified ORF, "Protein that stimulates strand exchange by facilitating Rad51p binding to single-stranded DNA; anneals complementary single-stranded DNA; involved in the repair of double-strand breaks in DNA during vegetative growth and meiosis" [yeast-bovrabprots.fasta] [chemostatdb.fasta] DNA repair and recombination protein RAD52 OS=Saccharomyces cerevisiae (strain ATCC 204508 / S288c) GN=RAD52 PE=1 SV=2 [UniProt_S_cerevisiae_20120516_05-16-2012_reversed.fasta] RAD52 SGDID:S000004494, Chr XIII from 213930-212515, Genome Release 64-1-1, reverse complement, Verified ORF, "Protein that stimulates strand exchange by facilitating Rad51p binding to single-stranded DNA; anneals complementary single-stranded DNA; involved in the repair of double-strand breaks in DNA during vegetative growth and meiosis" [yeast-030211-contam.fasta] RAD52 SGDID:S000004494, Chr XIII from 213930-212515, Genome Release 64-2-1, reverse complement, Verified ORF, "Protein that stimulates strand exchange; stimulates strand exchange by facilitating Rad51p binding to single-stranded DNA; anneals complementary single-stranded DNA; involved in the repair of double-strand breaks in DNA during vegetative growth and meiosis and UV induced sister chromatid recombination" [20141208_orf_trans.fasta] YML032C SGDID:S000004494, Chr XIII from 213930-212515, Genome Release 64-1-1, reverse complement, Verified ORF, "Protein that stimulates strand exchange by facilitating Rad51p binding to single-stranded DNA; anneals complementary single-stranded DNA; involved in the repair of double-strand breaks in DNA during vegetative growth and meiosis" [2016-01-SGD_Yeast_Contam_Riffle_20140507-Ska-Hec-110-tubulin.fasta]
Organism:	Saccharomyces cerevisiae
Length:	471 amino acids
Gene Ontology:
Cellular Component:	nucleus [IDA] nuclear chromosome [IDA]
Biological Process:	meiotic DNA recombinase assembly [TAS] double-strand break repair via break-induced replication [TAS] double-strand break repair via single-strand annealing [IGI] telomere maintenance via recombination [IMP] double-strand break repair via synthesis-dependent strand annealing [TAS] DNA recombinase assembly [IDA][TAS] postreplication repair [IMP]
Molecular Function:	DNA strand annealing activity [IDA] recombinase activity [IDA]

Sequence:

Sequence:
[PDR BLAST]
[ProtParam]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MNEIMDMDEK KPVFGNHSED IQTKLDKKLG PEYISKRVGF GTSRIAYIEG WRVINLANQI  60
   61 FGYNGWSTEV KSVVIDFLDE RQGKFSIGCT AIVRVTLTSG TYREDIGYGT VENERRKPAA 120
  121 FERAKKSAVT DALKRSLRGF GNALGNCLYD KDFLAKIDKV KFDPPDFDEN NLFRPTDEIS 180
  181 ESSRTNTLHE NQEQQQYPNK RRQLTKVTNT NPDSTKNLVK IENTVSRGTP MMAAPAEANS 240
  241 KNSSNKDTDL KSLDASKQDQ DDLLDDSLMF SDDFQDDDLI NMGNTNSNVL TTEKDPVVAK 300
  301 QSPTASSNPE AEQITFVTAK AATSVQNERY IGEESIFDPK YQAQSIRHTV DQTTSKHIPA 360
  361 SVLKDKTMTT ARDSVYEKFA PKGKQLSMKN NDKELGPHML EGAGNQVPRE TTPIKTNATA 420
  421 FPPAAAPRFA PPSKVVHPNG NGAVPAVPQQ RSTRREVGRP KINPLHARKP T

Protein Complex Data

	PUBLICATION	TOPOLOGY	COCOMPLEXED PROTEINS
View Details	Riffle et al. (2010) (Unpublished Data)		MPH1 RAD51 RAD52 RFA1 RFA2 RFA3 RIM1
View Details	(MIPS) Mewes HW, et al. (2004)		RAD51 RAD52 RAD54 RAD55 RAD57
View Details	Krogan NJ, et al. (2006)		RAD51 RAD52
View Details	Gavin AC, et al. (2006)		MPH1 MSH6 RAD52 RFA1
View Details	Gavin AC, et al. (2002)		ARO1 CCT8 CLU1 CMR1 CPA2 DNA2 ECM29 GCN20 GFA1 GUS1 HDA1 HDA2 HDA3 HSC82 IDH2 ILV1 KAP123 KAP95 LCD1 MEC1 MGM101 MKT1 MLH1 MPH1 MRPS28 MSH2 MSH3 MSH6 OLA1 PFK1 PGK1 PMS1 PRO2 RAD16 RAD23 RAD34 RAD4 RAD51 RAD52 RFA1 RFA2 RFA3 RIM1 RNH1 RPA135 RPB2 RPN10 RPN12 RPN3 RPN6 RPN8 RPN9 RPT2 RPT3 RPT6 RSC8 RVB2 SGS1 SHS1 SRO7 SSL1 TFA1 TFB1 TFB4 TIF1, TIF2 TOP3 VAS1 VPS1 YHB1 YHR122W
View Details	Ho Y, et al. (2002)		AAC3 AHA1 ALD5 ATP3 BEM2 ECM10 GCD11 HOM3 HOR2 ILV2 OYE2 PIL1 PRB1 PTC3 RAD52 RAD59 RHR2 SEC27 SEC53 TEF4 UBA1 VMA8 YER138C YPT31
View Details	Qiu et al. (2008)		RAD18 RAD51 RAD52

Mass Spectrometry Data

No mass spectrometry results found for this protein.

Yeast Two-Hybrid Data

The following interactions contain this protein:

NOT SHOWING SINGLE HITS. [ Show Single Hits ]

[View our yeast two-hybrid interpretation guidelines.]

No yeast two-hybrid interactions found for this protein.

	PROTEIN(S)	PUBLICATION
View Data	RAD52	Huh WK, et al. (2003)

TMHMM	2.0c	PSIPRED	v2.61
SignalP	3.0	COILS	1999
DISOPRED	v0.1	NCBI nr	06/2007
PSI-BLAST	2.2.18	FFAS	ffas03
PDB	06/2007	Pfam	22
HMMER	2.3.2

#		Region(s)	Method	Confidence	Match Description
1	View Details	[1..268]	PSI-BLAST	75.69897	The homologous-pairing domain of Rad52 recombinase
2	View Details	[269..471]	MSA	8.192997	View MSA. No confident structure predictions are available.

Protein predicted to be:	GLOBULAR (No transmembrane regions or signal peptide)
Confidence of classification:	0.99

Protein Overview: RAD52

Protein Complex Data

Mass Spectrometry Data

Yeast Two-Hybrid Data

Microscopy / Localization Data

Protein Structure Data

Philius Transmembrane Prediction: