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View Structure Prediction Details

Protein: RAD52
Organism: Saccharomyces cerevisiae
Length: 471 amino acids
Reference: Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076



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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for RAD52.

Description E-value Query
Range
Subject
Range
RAD52 - Protein that stimulates strand exchange by facilitating Rad51p binding to single-stranded DNA; annea...
0.0 [1..471] [34..504]
gi|23200258, gi|... - gi|23200266|pdb|1KN0|K Chain K, Crystal Structure Of The Human Rad52 Protein, gi|23200265|pdb|1KN0|J...
1.0E-74 [17..192] [35..212]
gi|17512302 - gi|17512302|gb|AAH19123.1| Rad52 protein [Mus musculus]
1.0E-74 [16..297] [35..317]
gi|6716781 - gi|6716781|gb|AAF26740.1|AF220495_1 Rad52 recombination protein [Cricetulus griseus]
3.0E-71 [17..297] [36..317]

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Predicted Domain #1
Region A:
Residues: [1-268]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MNEIMDMDEK KPVFGNHSED IQTKLDKKLG PEYISKRVGF GTSRIAYIEG WRVINLANQI  60
   61 FGYNGWSTEV KSVVIDFLDE RQGKFSIGCT AIVRVTLTSG TYREDIGYGT VENERRKPAA 120
  121 FERAKKSAVT DALKRSLRGF GNALGNCLYD KDFLAKIDKV KFDPPDFDEN NLFRPTDEIS 180
  181 ESSRTNTLHE NQEQQQYPNK RRQLTKVTNT NPDSTKNLVK IENTVSRGTP MMAAPAEANS 240
  241 KNSSNKDTDL KSLDASKQDQ DDLLDDSL

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 75.69897
Match: 1kn0A_
Description: The homologous-pairing domain of Rad52 recombinase
Matching Structure (courtesy of the PDB):

Predicted functions:

Term Confidence Notes
binding 3.09705138687537 bayes_pls_golite062009
nucleic acid binding 2.62582371207063 bayes_pls_golite062009
RNA binding 1.51047378734681 bayes_pls_golite062009
protein binding 1.33336414936007 bayes_pls_golite062009
DNA binding 1.09648705416581 bayes_pls_golite062009
DNA-dependent ATPase activity 0.904446819959466 bayes_pls_golite062009
structural constituent of ribosome 0.76025791808648 bayes_pls_golite062009
structural molecule activity 0.65255802837561 bayes_pls_golite062009
structure-specific DNA binding 0.642887555726933 bayes_pls_golite062009
transcription regulator activity 0.558060375765317 bayes_pls_golite062009
DNA helicase activity 0.44243422495341 bayes_pls_golite062009
cytoskeletal protein binding 0.403469167264307 bayes_pls_golite062009
double-stranded RNA binding 0.33006862628358 bayes_pls_golite062009
single-stranded DNA binding 0.314856869078672 bayes_pls_golite062009
double-stranded DNA binding 0.26445124843094 bayes_pls_golite062009
ATP-dependent DNA helicase activity 0.199046986762565 bayes_pls_golite062009
DNA strand annealing activity 0.12518470735954 bayes_pls_golite062009

Predicted Domain #2
Region A:
Residues: [269-471]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MFSDDFQDDD LINMGNTNSN VLTTEKDPVV AKQSPTASSN PEAEQITFVT AKAATSVQNE  60
   61 RYIGEESIFD PKYQAQSIRH TVDQTTSKHI PASVLKDKTM TTARDSVYEK FAPKGKQLSM 120
  121 KNNDKELGPH MLEGAGNQVP RETTPIKTNA TAFPPAAAPR FAPPSKVVHP NGNGAVPAVP 180
  181 QQRSTRREVG RPKINPLHAR KPT

[Run NCBI BLAST on this sequence.]

Detection Method: MSA

Shown below is our most confident prediction for this domain.
Click here to view all matches.

Found no confident structure predictions for this domain.


YRC Informatics Platform - Version 3.0
Created and Maintained by: Michael Riffle