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Protein Overview: RAD52

General Information:
Name(s) found: RAD52 / YML032C [SGD]
Description(s) found:
Found 14 descriptions.
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  • Protein that stimulates strand exchange by facilitating Rad51p binding to single-stranded DNA; anneals complementary single-stranded DNA; involved in the repair of double-strand breaks in DNA during vegetative growth and meiosis [SGD]
    • Organism: Saccharomyces cerevisiae
    Length: 504 amino acids

    Gene Ontology:
    Cellular Component: nucleus [IDALink to PubMed article]
    nuclear chromosome [IDALink to PubMed article]
    Biological Process: meiotic DNA recombinase assembly [TASLink to PubMed article]
    double-strand break repair via break-induced replication [TASLink to PubMed article]
    double-strand break repair via single-strand annealing [IGILink to PubMed article]
    telomere maintenance via recombination [IMPLink to PubMed article]
    double-strand break repair via synthesis-dependent strand annealing [TASLink to PubMed article]
    DNA recombinase assembly [IDALink to PubMed article][TASLink to PubMed article]
    postreplication repair [IMPLink to PubMed article]
    Molecular Function: DNA strand annealing activity [IDALink to PubMed article]
    recombinase activity [IDALink to PubMed article]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MAFLSYFATE NQQMQTRRLP RTAEGSGGFG VLLMNEIMDM DEKKPVFGNH SEDIQTKLDK  60
   61 KLGPEYISKR VGFGTSRIAY IEGWRVINLA NQIFGYNGWS TEVKSVVIDF LDERQGKFSI 120
  121 GCTAIVRVTL TSGTYREDIG YGTVENERRK PAAFERAKKS AVTDALKRSL RGFGNALGNC 180
  181 LYDKDFLAKI DKVKFDPPDF DENNLFRPTD EISESSRTNT LHENQEQQQY PNKRRQLTKV 240
  241 TNTNPDSTKN LVKIENTVSR GTPMMAAPAE ANSKNSSNKD TDLKSLDASK QDQDDLLDDS 300
  301 LMFSDDFQDD DLINMGNTNS NVLTTEKDPV VAKQSPTASS NPEAEQITFV TAKAATSVQN 360
  361 ERYIGEESIF DPKYQAQSIR HTVDQTTSKH IPASVLKDKT MTTARDSVYE KFAPKGKQLS 420
  421 MKNNDKELGP HMLEGAGNQV PRETTPIKTN ATAFPPAAAP RFAPPSKVVH PNGNGAVPAV 480
  481 PQQRSTRREV GRPKINPLHA RKPT

    Protein Complex Data

    No complex found for this protein.

    Mass Spectrometry Data

    No mass spectrometry results found for this protein.

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    NOT SHOWING SINGLE HITS. [ Show Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

    No yeast two-hybrid interactions found for this protein.

    Microscopy / Localization Data

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    No microscopy data found in the PDR for this protein.

    Protein Structure Data


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    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..145] MSA 3.018971 View MSA. No confident structure predictions are available.
    2 View Details [146..504] ORFEUS 13.36 RBP1


    Reference: Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076


    Philius Transmembrane Prediction:

    Protein predicted to be: GLOBULAR (No transmembrane regions or signal peptide)
    Confidence of classification: 0.99

    Source: Reynolds et al. (2008)

    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle