Protein Overview: NHP10

General Information:
Name(s) found:	NHP10 / YDL002C [SGD]
Description(s) found: SHOW ONLY BEST	gi\|642804\|emb\|CAA88059.1\| unknown [Saccharomyces cerevisiae] [NCBI NR] gi\|6320202\|ref\|NP_010282.1\| Protein related to mammalian high mobility group proteins; likely component of the INO80 complex, which is an ATP-dependent chromatin-remodeling complex; Nhp10p [Saccharomyces cerevisiae] [NCBI NR] gi\|2495255\|sp\|Q03435.1\|NHP10_YEAST RecName: Full=Non-histone protein 10; AltName: Full=High mobility group protein 2 [NCBI NR] pir\|\|S50980 NHP10 protein - yeast (Saccharomyces cerevisiae) [NCBI NR] Non-histone protein 10 OS=Saccharomyces cerevisiae GN=NHP10 PE=1 SV=1 [Swiss-Prot] (Q03435) Non-histone protein 10 (High mobility group protein 2) [Swiss-Prot] NHP10 Non-histone protein [mips] Protein related to mammalian high mobility group proteins; preferentially binds DNA ends, protecting them from exonucleatic cleavage; likely component of the chromatin-remodeling complex INO80 complex; proposed to be involved in DNA repair [SGD] NHP10, Chr IV from 446963-447574, reverse complement [yeast_orfs2] Chr IV from 446963-447574, reverse complement [yeastorf3.fasta] Chr IV from 447574-446963, reverse complement [yeastorf5.fasta] (Q03435) NHP10 protein [4932.FASTACCERV.txt] NHP10 SGDID:S0002160, Chr IV from 447575-446964, reverse complement, Verified ORF [yeastflysequest.fasta] Nhp10p [Saccharomyces cerevisiae]gi\|642804\|emb\|CAA88059.1\| unknown [Saccharomyces cerevisiae]gi\|2495255\|sp\|Q03435\|NH10_YEAST Non-histone protein 10 (High mobility group protein 2)gi\|1077510\|pir\|\|S50980 NHP10 protein - yeast (Saccharomyces cerevisiae) [nrdb_11152004_Chlamydomonas] NHP10 SGDID:S000002160, Chr IV from 447575-446964, reverse complement, Verified ORF, "Protein related to mammalian high mobility group proteins; likely component of the INO80 complex, which is an ATP-dependent chromatin-remodeling complex" [SGD_S-cerevisiae_na_12-16-2005_con_reversed.fasta] NHP10 SGDID:S000002160, Chr IV from 447576-446965, reverse complement, Verified ORF, "Protein related to mammalian high mobility group proteins; likely component of the INO80 complex, which is an ATP-dependent chromatin-remodeling complex" [SGD_S-cerevisiae_na_08-19-2008_con_reversed.fasta] unknown [Saccharomyces cerevisiae] [nr-271106-contam.fasta] Protein related to mammalian high mobility group proteins; likely component of the INO80 complex, which is an ATP-dependent chromatin-remodeling complex; Nhp10p [Saccharomyces cerevisiae] [nr-271106-contam.fasta] Non-histone protein 10 (High mobility group protein 2) [nr-271106-contam.fasta] NHP10 SGDID:S000002160, Chr IV from 447576-446965, reverse complement, Verified ORF, "Protein related to mammalian high mobility group proteins; binds preferentially to DNA ends and is able to protect them from exonuclease cleavage; likely component of th [SGD_S-cerevisiae_na_01-05-2010_reversed.fasta] [chemostatdb.fasta] NHP10 SGDID:S000002160, Chr IV from 447576-446965, reverse complement, Verified ORF, "Protein related to mammalian high mobility group proteins; binds preferentially to DNA ends and is able to protect them from exonuclease cleavage; likely component of the INO80 complex, which is an ATP-dependent chromatin-remodeling complex" [SGDyeast.20101221.fasta] Non-histone protein 10 OS=Saccharomyces cerevisiae (strain ATCC 204508 / S288c) GN=NHP10 PE=1 SV=1 [UniProt_S_cerevisiae_20120516_05-16-2012_reversed.fasta] NHP10 SGDID:S000002160, Chr IV from 447578-446967, Genome Release 64-1-1, reverse complement, Verified ORF, "Protein related to mammalian high mobility group proteins; preferentially binds DNA ends, protecting them from exonucleatic cleavage; likely component of the chromatin-remodeling complex INO80 complex; proposed to be involved in DNA repair" [yeast-030211-contam.fasta] NHP10 SGDID:S000002160, Chr IV from 447578-446967, Genome Release 64-2-1, reverse complement, Verified ORF, "Non-essential INO80 chromatin remodeling complex subunit; preferentially binds DNA ends, protecting them from exonucleatic cleavage; deletion affects telomere maintenance via recombination; related to mammalian high mobility group proteins" [20141208_orf_trans.fasta] YDL002C SGDID:S000002160, Chr IV from 447578-446967, Genome Release 64-1-1, reverse complement, Verified ORF, "Protein related to mammalian high mobility group proteins; preferentially binds DNA ends, protecting them from exonucleatic cleavage; likely component of the chromatin-remodeling complex INO80 complex; proposed to be involved in DNA repair" [2016-01-SGD_Yeast_Contam_Riffle_20140507-Ska-Hec-110-tubulin.fasta]
Organism:	Saccharomyces cerevisiae
Length:	203 amino acids
Gene Ontology:
Cellular Component:	nucleus [IDA] Ino80 complex [IPI]
Biological Process:	chromatin remodeling [IPI]
Molecular Function:	molecular_function [ND]

Sequence:

Sequence:
[PDR BLAST]
[ProtParam]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MSVEEKKRRL EELKDQNVVL GLAIQRSRLS VKRLKLEYGV LLERLESRIE LDPELNCEDP  60
   61 LPTLASFKQE LLTKPFRKSK TKRHKVKERD PNMPKRPTNA YLLYCEMNKE RIRQNGSLDV 120
  121 TRDLAEGWKN LNEQDRKPYY KLYSEDRERY QMEMEIYNKK ISNIDADDDK EENEQKIKNN 180
  181 EEGSSTKVAD SKGGEDGSLV SSN

Protein Complex Data

	PUBLICATION	TOPOLOGY	COCOMPLEXED PROTEINS
View Details	Riffle et al. (2010) (Unpublished Data)		ACT1 ARP4 ARP5 ARP8 IES1 IES2 IES3 IES5 INO80 NHP10 RVB1 RVB2 TAF14
View Details	Krogan NJ, et al. (2006)		ARP4 ARP5 ARP6 ARP8 CCA1 EAF1 EAF5 EAF6 EAF7 EPL1 ESA1 IES1 IES2 IES3 IES4 IES5 IES6 INO80 NHP10 NTO1 PIH1 RVB1 RVB2 SAS3 SWC3 SWC4 SWC5 SWC7 SWR1 TAH1 TRA1 VPS71 VPS72 YAF9 YNG2
View Details	Gavin AC, et al. (2006)		ARP5 ARP8 IES1 IES3 IES5 INO80 NHP10
View Details	Gavin AC, et al. (2002)		ABF2 ACT1 ADH1 ARP4 ARP8 CKA1 CKA2 CKB1 CKB2 CTI6 DEP1 DOT6 EAF3 ECM16 ESC8 HTA2 IES1 IES5 INO80 IOC3 ISW1 ISW2 ITC1 MED4 MOT1 NHP10 NPL6 NRD1 PHO23 RCO1 RPC40 RPD3 RSC2 RSC4 RSC58 RSC6 RSC8 RVB2 RXT2 RXT3 SAP30 SDS3 SIN3 STO1 TOP1 TUP1 UME1 UME6 VPS1

Mass Spectrometry Data

The following runs contain data for this protein:

	BAIT	COMMENTS	PUBLICATION
View Run	CEP3	sample cbf3 from feb 2005	Sandall S, et all (2006)

Yeast Two-Hybrid Data

The following interactions contain this protein:

NOT SHOWING SINGLE HITS. [ Show Single Hits ]

[View our yeast two-hybrid interpretation guidelines.]

No yeast two-hybrid interactions found for this protein.

	PROTEIN(S)	PUBLICATION
View Data	NHP10	Huh WK, et al. (2003)

TMHMM	2.0c	PSIPRED	v2.61
SignalP	3.0	COILS	1999
DISOPRED	v0.1	NCBI nr	06/2007
PSI-BLAST	2.2.18	FFAS	ffas03
PDB	06/2007	Pfam	22
HMMER	2.3.2

#		Region(s)	Method	Confidence	Match Description
1	View Details	[1..77]	PSI-BLAST	8.045757	HMG1, domains A and B
2	View Details	[78..203]	PSI-BLAST	73.69897	NHP6a

Protein predicted to be:	GLOBULAR (No transmembrane regions or signal peptide)
Confidence of classification:	0.99

Protein Overview: NHP10

Protein Complex Data

Mass Spectrometry Data

Yeast Two-Hybrid Data

Microscopy / Localization Data

Protein Structure Data

Philius Transmembrane Prediction: