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View Structure Prediction Details

Protein: NHP10
Organism: Saccharomyces cerevisiae
Length: 203 amino acids
Reference: Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076



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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for NHP10.

Description E-value Query
Range
Subject
Range
gi|7507776 - gi|7507776|pir||T16867 probable cytochrome P450 T13C5.1 [similarity] - Caenorhabditis elegans
1.0E-37 [3..162] [170..343]
gi|220953466, gi... - gi|220953466|gb|ACL89276.1| Dsp1-PA [synthetic construct], gi|220943192|gb|ACL84139.1| Dsp1-PA [synt...
Dsp1-PA, Dsp1-PB... - The gene Dorsal switch protein 1 is referred to in FlyBase by the symbol Dmel\Dsp1 (CG12223, FBgn001...
3.0E-37 [3..162] [162..335]
gi|185134049, gi... - gi|185134049|ref|NP_001117742.1| SOX9 alpha2 [Oncorhynchus mykiss], gi|12003242|gb|AAG43497.1|AF2098...
7.0E-35 [7..201] [20..225]
gi|14290107 - gi|14290107|gb|AAK59254.1| HMG box transcription factor Sox9a1 [Monopterus albus]
1.0E-34 [7..201] [20..220]
gi|3342573 - gi|3342573|gb|AAC27651.1| high mobility group protein [Spalax ehrenbergi]
5.0E-34 [3..168] [1..173]
gi|16945893, gi|... - gi|33415940|gb|AAQ18507.1| transcription factor Sox9a [Takifugu rubripes], gi|16945893|gb|AAL32172.1...
2.0E-33 [7..201] [20..220]

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Predicted Domain #1
Region A:
Residues: [1-77]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MSVEEKKRRL EELKDQNVVL GLAIQRSRLS VKRLKLEYGV LLERLESRIE LDPELNCEDP  60
   61 LPTLASFKQE LLTKPFR

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 8.045757
Match: 1aab__
Description: HMG1, domains A and B
Matching Structure (courtesy of the PDB):

Predicted functions:

Term Confidence Notes
binding 3.47326864033978 bayes_pls_golite062009
sequence-specific DNA binding 2.71554076177339 bayes_pls_golite062009
DNA binding 2.47408268953466 bayes_pls_golite062009
nucleic acid binding 2.43458430104304 bayes_pls_golite062009
transcription regulator activity 1.94466966241938 bayes_pls_golite062009
transcription factor binding 1.70152980531918 bayes_pls_golite062009
chromatin binding 1.63780144452084 bayes_pls_golite062009
transcription activator activity 1.44874740508684 bayes_pls_golite062009
transcription repressor activity 1.4027949566969 bayes_pls_golite062009
protein binding 1.33904668423876 bayes_pls_golite062009
transcription factor activity 1.12823770442876 bayes_pls_golite062009
structure-specific DNA binding 0.837636448794941 bayes_pls_golite062009
RNA polymerase II transcription factor activity 0.67573816815318 bayes_pls_golite062009
transcription coactivator activity 0.341133967674497 bayes_pls_golite062009
transcription cofactor activity 0.113222211905324 bayes_pls_golite062009

Predicted Domain #2
Region A:
Residues: [78-203]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 KSKTKRHKVK ERDPNMPKRP TNAYLLYCEM NKERIRQNGS LDVTRDLAEG WKNLNEQDRK  60
   61 PYYKLYSEDR ERYQMEMEIY NKKISNIDAD DDKEENEQKI KNNEEGSSTK VADSKGGEDG 120
  121 SLVSSN

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 73.69897
Match: 1cg7A_
Description: NHP6a
Matching Structure (courtesy of the PDB):

Predicted functions:

Term Confidence Notes
binding 3.47326864033978 bayes_pls_golite062009
sequence-specific DNA binding 2.71554076177339 bayes_pls_golite062009
DNA binding 2.47408268953466 bayes_pls_golite062009
nucleic acid binding 2.43458430104304 bayes_pls_golite062009
transcription regulator activity 1.94466966241938 bayes_pls_golite062009
transcription factor binding 1.70152980531918 bayes_pls_golite062009
chromatin binding 1.63780144452084 bayes_pls_golite062009
transcription activator activity 1.44874740508684 bayes_pls_golite062009
transcription repressor activity 1.4027949566969 bayes_pls_golite062009
protein binding 1.33904668423876 bayes_pls_golite062009
transcription factor activity 1.12823770442876 bayes_pls_golite062009
structure-specific DNA binding 0.837636448794941 bayes_pls_golite062009
RNA polymerase II transcription factor activity 0.67573816815318 bayes_pls_golite062009
transcription coactivator activity 0.341133967674497 bayes_pls_golite062009
transcription cofactor activity 0.113222211905324 bayes_pls_golite062009

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