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Protein Overview: HCA4

General Information:
Name(s) found: HCA4 / YJL033W [SGD]
Description(s) found:
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  • gi|6322427|ref|NP_012501.1| Putative nucleolar DEAD box RNA helicase; high-copy number suppression of a U14 snoRNA processing mutant suggests an involvement in 18S rRNA synthesis; Hca4p [Saccharomyces cerevisiae] [NCBI NR]
  • gi|1170186|sp|P20448.2|DBP4_YEAST RecName: Full=ATP-dependent RNA helicase DBP4; AltName: Full=DEAD box protein 4; AltName: Full=Helicase CA4; AltName: Full=Helicase UF1 [NCBI NR]
  • pir||S56805 probable RNA helicase CA4 - yeast (Saccharomyces cerevisiae) [NCBI NR]
  • gi|1008155|emb|CAA89324.1| HCA4 [Saccharomyces cerevisiae] [NCBI NR]
  • ATP-dependent RNA helicase DBP4 OS=Saccharomyces cerevisiae GN=DBP4 PE=1 SV=2 [Swiss-Prot]
  • HCA4 Can suppress the U14 snoRNA rRNA processing function [mips]
  • Putative nucleolar DEAD box RNA helicase; high-copy number suppression of a U14 snoRNA processing mutant suggests an involvement in 18S rRNA synthesis [SGD]
  • HCA4, Chr X from 383533-385845 [yeast_orfs2]
  • Chr X from 383533-385845 [yeastorf3.fasta]
  • (P20448) Probable ATP-dependent RNA helicase DBP4 (Helicase CA4) (Helicase UF1) [4932.FASTACCERV.txt]
  • HCA4 SGDID:S0003570, Chr X from 383753-386065, Verified ORF [yeastflysequest.fasta]
  • Hca4p [Saccharomyces cerevisiae]gi|1008155|emb|CAA89324.1| HCA4 [Saccharomyces cerevisiae]gi|1078295|pir||S56805 probable RNA helicase CA4 - yeast (Saccharomyces cerevisiae)gi|1170186|sp|P20448|DBP4_YEAST Probable ATP-dependent RNA helicase DBP4 (Helic [nrdb_11152004_Chlamydomonas]
  • HCA4 SGDID:S000003570, Chr X from 383753-386065, Verified ORF, "Putative nucleolar DEAD box RNA helicase; high-copy number suppression of a U14 snoRNA processing mutant suggests an involvement in 18S rRNA synthesis" [SGD_S-cerevisiae_na_12-16-2005_con_reversed.fasta]
  • HCA4 SGDID:S000003570, Chr X from 383832-386144, Verified ORF, "Putative nucleolar DEAD box RNA helicase; high-copy number suppression of a U14 snoRNA processing mutant suggests an involvement in 18S rRNA synthesis" [yeast-contam.fasta]
  • HCA4 SGDID:S000003570, Chr X from 383831-386143, Verified ORF, "Putative nucleolar DEAD box RNA helicase; high-copy number suppression of a U14 snoRNA processing mutant suggests an involvement in 18S rRNA synthesis" [yeast-200209-contam.fasta]
  • HCA4 [Saccharomyces cerevisiae] [nr-271106-contam.fasta]
  • Putative nucleolar DEAD box RNA helicase; high-copy number suppression of a U14 snoRNA processing mutant suggests an involvement in 18S rRNA synthesis; Hca4p [Saccharomyces cerevisiae] [nr-271106-contam.fasta]
  • ATP-dependent RNA helicase DBP4 (DEAD box protein 4) (Helicase CA4) (Helicase UF1) [nr-271106-contam.fasta]
  • [chemostatdb.fasta]
  • ATP-dependent RNA helicase HCA4 OS=Saccharomyces cerevisiae (strain ATCC 204508 / S288c) GN=HCA4 PE=1 SV=2 [UniProt_S_cerevisiae_20120516_05-16-2012_reversed.fasta]
  • HCA4 SGDID:S000003570, Chr X from 383837-386149, Genome Release 64-1-1, Verified ORF, "Putative nucleolar DEAD box RNA helicase; high-copy number suppression of a U14 snoRNA processing mutant suggests an involvement in 18S rRNA synthesis" [yeast-030211-contam.fasta]
  • HCA4 SGDID:S000003570, Chr X from 383837-386149, Genome Release 64-2-1, Verified ORF, "DEAD box RNA helicase; component of the SSU; interacts with Bfr2p and Enp2p; high-copy number suppression of a U14 snoRNA processing mutant suggests an involvement in 18S rRNA synthesis" [20141208_orf_trans.fasta]
  • YJL033W SGDID:S000003570, Chr X from 383837-386149, Genome Release 64-1-1, Verified ORF, "Putative nucleolar DEAD box RNA helicase; high-copy number suppression of a U14 snoRNA processing mutant suggests an involvement in 18S rRNA synthesis" [2016-01-SGD_Yeast_Contam_Riffle_20140507-Ska-Hec-110-tubulin.fasta]
    • Organism: Saccharomyces cerevisiae
    Length: 770 amino acids

    Gene Ontology:
    Cellular Component: nuclear outer membrane [IMPLink to PubMed article]
    nucleolus [ICLink to PubMed article]
    Biological Process: ribosome biogenesis [RCALink to PubMed article]
    Molecular Function: ATP-dependent RNA helicase activity [IMPLink to PubMed article]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MAKKNRLNTT QRKTLRQKED EYIENLKTKI DEYDPKITKA KFFKDLPISD PTLKGLRESS  60
   61 FIKLTEIQAD SIPVSLQGHD VLAAAKTGSG KTLAFLVPVI EKLYREKWTE FDGLGALIIS 120
  121 PTRELAMQIY EVLTKIGSHT SFSAGLVIGG KDVKFELERI SRINILIGTP GRILQHLDQA 180
  181 VGLNTSNLQM LVLDEADRCL DMGFKKTLDA IVSTLSPSRQ TLLFSATQSQ SVADLARLSL 240
  241 TDYKTVGTHD VMDGSVNKEA STPETLQQFY IEVPLADKLD ILFSFIKSHL KCKMIVFLSS 300
  301 SKQVHFVYET FRKMQPGISL MHLHGRQKQR ARTETLDKFN RAQQVCLFAT DVVARGIDFP 360
  361 AVDWVVQVDC PEDVDTYIHR VGRCARYGKK GKSLIMLTPQ EQEAFLKRLN ARKIEPGKLN 420
  421 IKQSKKKSIK PQLQSLLFKD PELKYLGQKA FISYVRSIYV QKDKQVFKFD ELPTEEFAYS 480
  481 LGLPGAPKIK MKGMKTIEQA KERKNAPRQL AFLSKANEDG EVIEDKSKQP RTKYDKMFER 540
  541 KNQTILSEHY LNITKAQAQE DEDDDFISVK RKDHEINEAE LPALTLPTSR RAQKKALSKK 600
  601 ASLASKGNAS KLIFDDEGEA HPVYELEDEE EFHKRGDAEV QKTEFLTKES AVMADIDNID 660
  661 KQVAKEKKQE KKRKRLEAMR REMEAAMEEE ISGDEEEGKT VAYLGTGNLS DDMSDGDMPD 720
  721 SEGHLKKKAR TVDYSHGHNP SNSVDDDIIE VEEPQTLEDL ESLTAKLIQG

    Protein Complex Data

      PUBLICATION TOPOLOGY COCOMPLEXED PROTEINS
    View Details Riffle et al. (2010) (Unpublished Data) BFR2 BMS1 ENP2 ESF1 ESF2 HCA4 KRE33 KRI1 LCP5 MAK21 NOP12 NOP53 NOP56 NOP58 RPF2 RPL10 RPL11B RPL15A RPL20B RPL2A, RPL2B RPL36A RPL4A RPL5 RPL6A RPS11A, RPS11B RPS16B, RPS16A RPS4B, RPS4A RPS8B, RPS8A RRP12 RRP3 UTP22
    View Details Hazbun TR, et al. (2003) BFR2 ENP2 ESF1 HCA4 LCP5 NOP58 UTP9
    View Details Krogan NJ, et al. (2006) BFR2 FUN14 HCA4 KRE33 LCP5
    View Details Gavin AC, et al. (2006) DBP8 ESF1 HCA4 MVD1 NOP56 NRP1
    View Details Gavin AC, et al. (2002) ADE4 ASC1 BFR2 BMS1 BRX1 BUD21 CBF5 CFT2 CKA1 CKA2 CKB1 CKB2 CMS1 DBP8 DIA4 DIM1 DIP2 DIS3 ECM16 ECM29 EMG1 ENP1 ENP2 ERO1 ESF1 ESF2 FAP7 FIP1 GCN1 GLC7 HAS1 HCA4 HHF1, HHF2 HSL1 HTA2 IML1 IMP3 IMP4 KRE33 KRR1 LCP5 LHP1 LTV1 MPP10 MRD1 MVD1 NAB3 NAB6 NAM7 NAN1 NOB1 NOC2 NOC4 NOP1 NOP12 NOP14 NOP56 NOP58 NOP6 NPL3 NRD1 NRP1 PAP1 PFS2 PNO1 POL2 PRE6 PRE9 PRP43 PTA1 PTI1 PUB1 PWP2 RCL1 REF2 RML2 RNA14 ROK1 RPP2B RRP12 RRP7 RRP9 RTG2 SAM1 SCL1 SEC21 SGN1 SLX9 SMD3 SNF2 SOF1 SRO9 STO1 SWI1 TIF1, TIF2 TIF4631 TIF4632 TSR1 UTP10 UTP11 UTP13 UTP15 UTP18 UTP20 UTP21 UTP22 UTP30 UTP4 UTP6 UTP7 UTP8 UTP9 YOR059C YSH1
    View Details Qiu et al. (2008) BRX1 DBP10 DBP3 DBP6 DBP7 DBP8 DHR2 DRS1 FAL1 GAR1 HCA4 KRI1 KRR1 MAK5 MTR4 NAN1 NOP12 NOP15 NOP2 NSR1 NUG1 POP1 PRP43 PWP2 PXR1 RNT1 ROK1 RPF2 RRP1 RRP3 RRP8 RRP9 RRT14 SPB4 UTP10 UTP4 UTP5 UTP8 UTP9

    Mass Spectrometry Data

    The following runs contain data for this protein:

      BAIT COMMENTS PUBLICATION
    View Run ESF1 No Comments Hazbun TR, et al. (2003)
    View Run ESF1 No Comments Hazbun TR, et al. (2003)
    View Run MLP2 #32 Asynchronous Prep-No Phosphopeptide enrichment Keck JM, et al. (2011)

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    NOT SHOWING SINGLE HITS. [ Show Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

    No yeast two-hybrid interactions found for this protein.

    Microscopy / Localization Data

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      PROTEIN(S) PUBLICATION
    View Data HCA4 and NOP56 Huh WK, et al. (2003)
    View Data HCA4 Huh WK, et al. (2003)

    Protein Structure Data


    [What does the above image mean?]
    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..261] PSI-BLAST 581.9794 Putative DEAD box RNA helicase
    2 View Details [262..411] PSI-BLAST 581.9794 Putative DEAD box RNA helicase
    3 View Details [412..529] PSI-BLAST 8.09691 Nucleotide excision repair enzyme UvrB
    4 View Details [530..770] MSA 3.115996 View MSA. No confident structure predictions are available.


    Reference: Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076


    Philius Transmembrane Prediction:

    Protein predicted to be: GLOBULAR (No transmembrane regions or signal peptide)
    Confidence of classification: 0.99

    Source: Reynolds et al. (2008)

    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle